担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

In the midst of globalization, English is regarded as an international language, or Lingua Franca, but learning it as a second language (L2) remains still difficult to speakers of other languages. This is true especially for the speakers of languages distantly related to English such as Japanese. In this sense, exploring neural basis for translation between the first language (L1) and L2 is of great interest. There have been relatively many previous researches revealing brain activation patterns during translations between L1 and English as L2. These studies, which focused on language translation with close or moderate linguistic distance (LD), have suggested that the Broca area (BA 44/45) and the dorsolateral prefrontal cortex (DLPFC; BA 46) may play an important role on translation. However, the neural mechanism of language translation between Japanese and English, having large LD, has not been clarified. Thus, we used functional near infrared spectroscopy (fNIRS) to investigate the brain activation patterns during word translation between Japanese and English. We also assessed the effects of translation directions and word familiarity. All participants' first language was Japanese and they were learning English. Their English proficiency was advanced or elementary. We selected English and Japanese words as stimuli based on the familiarity for Japanese people. Our results showed that the brain activation patterns during word translation largely differed depending on their English proficiency. The advanced group elicited greater activation on the left prefrontal cortex around the Broca's area while translating words with low familiarity, but no activation was observed while translating words with high familiarity. On the other hand, the elementary group evoked greater activation on the left temporal area including the superior temporal gyrus (STG) irrespective of the word familiarity. These results suggested that different cognitive process could be involved in word translation corresponding to English proficiency in Japanese learners of English. These difference on the brain activation patterns between the advanced and elementary group may reflect the difference on the cognitive loads depending on the levels of automatization in one's language processing.

DOI： 10.3389/fnhum.2021.593108

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnhum.2019.00016

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.nicl.2015.06.011

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.1.2.025007

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.1.1.015004

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.1.1.015001

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2013.07.025

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.nicl.2014.09.001

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0031014

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.nicl.2012.10.001

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2006.10.043

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2006.09.024

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

The registration of functional brain data to the common brain space offers great advantages for inter-modal data integration and sharing. However, this is difficult to achieve in functional near-infrared spectroscopy (fNIRS) because fNIRS data are primary obtained from the head surface and lack structural information of the measured brain. Therefore, in our previous articles, we presented a method for probabilistic registration of fNIRS data to the standard Montreal Neurological Institute (MNI) template through international 10-20 system without using the subject's magnetic resonance image (MRI). In the current study, we demonstrate our method with a new statistical model to facilitate group studies and provide information on different components of variability. We adopt an analysis similar to the single-factor one-way classification analysis of variance based on random effects model to examine the variability involved in our improvised method of probabilistic registration of fNIRS data. We tested this method by registering head surface data of twelve subjects to seventeen reference MRI data sets and found that the standard deviation in probabilistic registration thus performed for given head surface points is approximately within the range of 4.7 to 7.0 mm. This means that, if the spatial registration error is within an acceptable tolerance limit, it is possible to perform multi-subject fNIRS analysis to make inference at the population level and to provide information on positional variability in the population, even when subjects' MRIs are not available. In essence, the current method enables the multi-subject fNIRS data to be presented in the MNI space with clear description of associated positional variability. Such data presentation on a common platform, will not only strengthen the validity of the population analysis of fNIRS studies, but will also facilitate both intra- and inter-modal data sharing among the neuroimaging community.

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

The recent advent of multichannel near-infrared spectroscopy (NIRS) has expanded its technical potential for human brain mapping. However, NIRS measurement has a technical drawback in that it measures cortical activities from the head surface without anatomical information of the object to be measured. This problem is also found in transcranial magnetic stimulation (TMS) that transcranially activates or inactivates the cortical surface. To overcome this drawback, we examined cranio-cerebral correlation using magnetic resonance imaging (MRI) via the guidance of the international 10-20 system for electrode placement, which had originally been developed for electroencephalography. We projected the 10-20 standard cranial positions over the cerebral cortical surface. After examining the cranio-cerebral correspondence for 17 healthy adults, we normalized the 10-20 cortical projection points of the subjects to the standard Montreal Neurological Institute (MNI) and Talairach stereotactic coordinates and obtained their probabilistic distributions. We also expressed the anatomical structures for the 10-20 cortical projection points probabilistically. Next, we examined the distance between the cortical surface and the head surface along the scalp and created a cortical surface depth map. We found that the locations of 10-20 cortical projection points in the standard MNI or Talairach space could be estimated with an average standard deviation of 8 mm. This study provided an initial step toward establishing a three-dimensional probabilistic anatomical platform that enables intra- and intermodal comparisons of NIRS and TMS brain imaging data.

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担当区分：筆頭著者,　責任著者  

DOI： 10.1016/S0962-8924(01)01980-8

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担当区分：最終著者,　責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Society of Kansei Engineering  

DOI： 10.5057/ijae.ijae-d-24-00013

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担当区分：最終著者,　責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Society of Kansei Engineering  

DOI： 10.5057/ijae.ijae-d-24-00016

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: This study undertook neuropharmacological research on the clinical course of controlled medication discontinuation to guide practitioners who are considering stopping medications for youths with attention-deficit hyperactivity disorder (ADHD). METHODS: This study analyzed the data for 14 ADHD children (12 male and 2 female) in two datasets: The children prescribed methylphenidate (MPH) were at an initial mean age of 7.5 years (SD = 1.70, range: 6-11) with a mean ADHD-Rating Score (ADHD-RS) of 26.6 (SD = 8.64, range 15-40). The children who discontinued MPH based on clinical judgment were at a mean age of 12.21 years (SD = 2.12, range: 8-15) with a mean ADHD-RS of 15.9 (SD = 6.86, range 5-27). The go/no-go task was used to assess response inhibition, while functional near-infrared spectroscopy (fNIRS) was used to measure cerebral hemodynamics. Oxygenated hemoglobin (Oxy-Hb) values from fNIRS data were analyzed for each subject, focusing on past and current measurements. Baseline was set at 10 s pre-task, with interval means from 4 to 24 s analyzed. One-sample t-tests were used to evaluate brain activity magnitude. RESULTS: The results of the study demonstrate that the children who had discontinued the medication exhibited activation in specific brain regions including the frontopolar cortex and the right ventrolateral prefrontal cortex. Activation (t = 2.363, p = 0.034, Cohen's d = 0.632) was found especially in the right dorsolateral prefrontal cortex during the performance of the go/no-go task. These activated areas were consistent with those observed in a previous study comparing brain activity during a go/no-go task between children with ADHD and healthy children. CONCLUSION: The present study showed differences in cerebral hemodynamics before and after discontinuation of MPH in ADHD children whose ADHD symptoms did not recur after MPH was discontinued. In the near future, further investigations that include control groups will be conducted to demonstrate the effects of MPH prior to discontinuation based on the changes in cerebral blood flow in the right prefrontal cortex, which is involved in behavioral inhibition, as observed in this study. This and future research will facilitate the development of criteria for discontinuing treatment.

DOI： 10.1016/j.braindev.2024.09.004

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掲載種別：研究論文（学術雑誌）   出版者・発行元：MIT Press  

Abstract

A growing number of studies have revealed that higher aerobic fitness is associated with better working memory (WM) performance in older adults. However, the underlying functional neural mechanisms of this association remain under debate. It has been reported that aging increases recruitment of the prefrontal cortex (PFC) during cognitive tasks, and that this is associated with task performance in a compensatory manner. Therefore, this study aimed to clarify the prefrontal activation pattern that is associated with the relationship between aerobic fitness and WM performance in older adults, focusing on age-related extended prefrontal recruitment. Forty-seven older adults (65–74 years, 29 females) and 49 younger adults (18–24 years, 23 female) performed verbal and spatial n-back tasks, which included 0-, 1-, and 2-back conditions. Reaction time (RT) and accuracy (ACC) were assessed as indices of task performance. Prefrontal activation during the experimental tasks was monitored using functional near-infrared spectroscopy (fNIRS) and analyzed using an adaptive GLM method. We compared task performance and prefrontal activation between age groups to find age-related prefrontal activation patterns. Only older adults underwent a graded exercise test (GXT) to determine their ventilation thresholds (VT) as a measure of aerobic fitness, and, subsequently, the relationships among aerobic fitness, n-back task performance, and prefrontal activation in older adults were examined using correlation analysis and mediation analysis controlling for possible covariates. A comparison of task performance between groups revealed that older adults had slower RT and lower ACC than did younger adults, especially in the higher WM load 2-back condition. Group comparisons of prefrontal activation showed that older adults exhibited additional or greater activation than younger adults mainly in the ventrolateral PFC (VLPFC) and front polar area (FPA) in both the verbal and spatial 2-back conditions. Correlation analysis showed a relationship between higher VT, shorter RT for the verbal 2-back condition, and greater prefrontal activation of the bilateral FPA and right VLPFC during verbal 2-back conditions in older adults. In addition, mediation analyses indicated the possibility of a mediation effect of the prefrontal activation on the relationship between VT and RT for the verbal 2-back condition. These results suggest that older adults with higher aerobic fitness levels recruited more extended PFC regions, possibly for compensatory activation, to enhance their performance of the verbal n-back task. This study sheds light on the neural mechanisms underpinning the relationship between aerobic fitness and cognitive function in older adults.

DOI： 10.1162/imag_a_00167

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担当区分：最終著者   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnrgo.2024.1331083

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担当区分：最終著者,　責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers Media SA  

Introduction

Humans mainly utilize visual and auditory information as a cue to infer others’ emotions. Previous neuroimaging studies have shown the neural basis of memory processing based on facial expression, but few studies have examined it based on vocal cues. Thus, we aimed to investigate brain regions associated with emotional judgment based on vocal cues using an N-back task paradigm.

Methods

Thirty participants performed N-back tasks requiring them to judge emotion or gender from voices that contained both emotion and gender information. During these tasks, cerebral hemodynamic response was measured using functional near-infrared spectroscopy (fNIRS).

Results

The results revealed that during the Emotion 2-back task there was significant activation in the frontal area, including the right precentral and inferior frontal gyri, possibly reflecting the function of an attentional network with auditory top-down processing. In addition, there was significant activation in the ventrolateral prefrontal cortex, which is known to be a major part of the working memory center.

Discussion

These results suggest that, compared to judging the gender of voice stimuli, when judging emotional information, attention is directed more deeply and demands for higher-order cognition, including working memory, are greater. We have revealed for the first time the specific neural basis for emotional judgments based on vocal cues compared to that for gender judgments based on vocal cues.

DOI： 10.3389/fnhum.2023.1160392

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5057/ijae.tjske-d-22-00075

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5057/ijae.tjske-d-22-00020

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担当区分：最終著者,　責任著者   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnrgo.2023.1207484

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly applicable to animal studies, here, we highlight optical spectroscopy and imaging methods relevant to noninvasive human brain studies. We outline current state-of-the-art technologies and software advances, explore the most recent impact of these technologies on neuroscience and clinical applications, identify the areas where innovation is needed, and provide an outlook for the future directions.

DOI： 10.1117/1.NPh.9.S2.S24001

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective. Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technique for monitoring hemoglobin concentration changes in a non-invasive manner. However, subject movements are often significant sources of artifacts. While several methods have been developed for suppressing this confounding noise, the conventional techniques have limitations on optimal selections of model parameters across participants or brain regions. To address this shortcoming, we aim to propose a method based on a deep convolutional neural network (CNN).Approach. The U-net is employed as a CNN architecture. Specifically, large-scale training and testing data are generated by combining variants of hemodynamic response function (HRF) with experimental measurements of motion noises. The neural network is then trained to reconstruct hemodynamic response coupled to neuronal activity with a reduction of motion artifacts.Main results. Using extensive analysis, we show that the proposed method estimates the task-related HRF more accurately than the existing methods of wavelet decomposition and autoregressive models. Specifically, the mean squared error and variance of HRF estimates, based on the CNN, are the smallest among all methods considered in this study. These results are more prominent when the semi-simulated data contain variants of shapes and amplitudes of HRF.Significance. The proposed CNN method allows for accurately estimating amplitude and shape of HRF with significant reduction of motion artifacts. This method may have a great potential for monitoring HRF changes in real-life settings that involve excessive motion artifacts.

DOI： 10.1088/1741-2552/ac4bfc

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The therapeutic values of contact with nature have been increasingly recognized. A growing body of evidence suggests that a unique subcategory of "contemplative landscapes" is particularly therapeutic. Previous studies predominantly focused on observational designs in non-clinical populations. It is not known if these effects can be extrapolated to populations suffering from depression, and experimental designs need to be utilized to establish causality. We examined the effects of in-situ passive exposure to three urban spaces on brain activity, namely a Therapeutic Garden with high Contemplative Landscape scores (TG), Residential Green (RG) and Busy Downtown (BD), and self-reported momentary mood in adults aged 21-74 (n = 92), including 24 clinically depressed and 68 healthy participants. Portable, multimodal electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) systems were used to record brain activity, and a Profile of Mood States (POMS) questionnaire was used to record mood before and after exposure. We tested the interactions between the site, time and group for the mood, and between site and group for the neuroelectric oscillations and brain hemodynamics. Self-reported pre- post-mood was significant only at the TG (p = 0.032) in both groups. The lowest Total Mood Disturbance (TMD) was reported at TG and the highest in BD (p = 0.026). Results from fNIRS indicated marginally significant lower oxy-Hb in the frontal region at TG as compared to BD (p = 0.054) across both groups. The marginally significant effect of site and group was also observed (p = 0.062), with the Clinical group showing much lower oxy-Hb at TG than Healthy. The opposite pattern was observed at BD. EEG results showed differences between Healthy and Clinical groups in the Frontal Alpha Asymmetry (FAA) pattern across the sites (p = 0.04), with more frontal alpha right in the Clinical sample and more left lateralization in the Healthy sample at TG. Temporal Beta Asymmetry (TBA) analyses suggested that patients displayed lower bottom-up attention than Healthy participants across all sites (p = 0.039). The results suggest that both healthy and depressed adults benefitted from exposure to TG, with possibly different pathways of mood improvement. Visiting therapeutic nature with contemplative features may provide valuable support for the treatment of depression in clinical populations and a self-care intervention in non-clinical populations.

DOI： 10.3389/fpsyt.2022.757056

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担当区分：最終著者   掲載種別：研究論文（学術雑誌）  

<jats:p>Understanding consumer preferences and behavior is a major goal of consumer-oriented companies. The application of neuroscience to this goal is a promising avenue for companies. Previously, we observed a positive correlation during actual cosmetic use between the right dorsolateral prefrontal cortex (dlPFC) activity, measured by functional near-infrared spectroscopy (fNIRS), and the associated willingness-to-pay (WTP) values. However, we were unable to find any consistent group differences in the right dlPFC between different powdery foundations. Thus, the main objective of this study was to replicate the previous study and in addition, we aimed to refine the method of the previous study to increase the chance that a difference in valuation between different products can be detected. Twenty-five frequent lipstick using females were asked to apply six different lipsticks to their lips and to record how much they were willing to pay. To maximize the variation of the subjective experience of the products and the associated brain activity, the most preferred color lipstick and a less preferred color lipstick were chosen for each participant, and each color of lipstick had three different textures (<jats:italic>Lo, Mid</jats:italic>, and <jats:italic>Hi</jats:italic>). The time series was analyzed with the general linear model (GLM) and the correlation between the right dlPFC beta scores for the lipsticks and their respective WTP values conducted for each participant. This revealed a significant positive correlation and replicated our previous study. Surprisingly, the lipstick color and the texture manipulations did not result in any consistent differences in WTP and similarly no consistent group differences in brain activations. This study replicates our previous study extending it to a different type of cosmetic. The right dlPFC activity during the use of cosmetics may be a potential brain-based personalization or product selection process biomarker.</jats:p>

DOI： 10.3389/fnrgo.2021.731160

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers Media SA  

<bold>Objective:</bold> In the current study, we explored the neural substrate for acute effects of guanfacine extended release (GXR) on inhibitory control in school-aged children with attention deficit hyperactivity disorder (ADHD), using functional near-infrared spectroscopy (fNIRS).

<bold>Methods:</bold> Following a GXR washout period, 12 AD HD children (6–10 years old) performed a go/no-go task before and 3 h after GXR or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design study. In the primary analysis, fNIRS was used to monitor the right prefrontal cortical hemodynamics of the participants, where our former studies showed consistent dysfunction and osmotic release oral system-methylphenidate (OROS-MPH) and atomoxetine hydrochloride (ATX) elicited recovery. We examined the inter-medication contrast, comparing the effect of GXR against the placebo. In the exploratory analysis, we explored neural responses in regions other than the right prefrontal cortex (PFC).

<bold>Results:</bold> In the primary analysis, we observed no significant main effects or interactions of medication type and age in month (two-way mixed ANCOVA, <italic>Fs</italic> &amp;lt; 0.20, all <italic>ps</italic> &amp;gt; .05). However, in the <italic>post-hoc</italic> analysis, we observed significant change in the oxy-Hb signal in the right angular gyrus (AG) for inter-medication (one sample <italic>t</italic>-test, <italic>p</italic> &amp;lt; 0.05, uncorrected, Cohen's <italic>d</italic> = 0.71).

<bold>Conclusions:</bold> These results are different from the neuropharmacological effects of OROS-MPH and ATX, which, in an upregulated manner, reduced right PFC function in ADHD children during inhibitory tasks. This analysis, while limited by its secondary nature, suggested that the improved cognitive performance was associated with activation in the right AG, which might serve as a biological marker to monitor the effect of GXR in the ADHD children.

DOI： 10.3389/fnrgo.2021.657657

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

(1) Background: Prolonged lockdowns with stay-at-home orders have been introduced in many countries since the outbreak of the COVID-19 pandemic. They have caused a drastic change in the everyday lives of people living in urbanized areas, and are considered to contribute to a modified perception of the public space. As research related to the impact of COVID-19 restrictions on mental health and well-being emerges, the associated longitudinal changes of brain hemodynamics in healthy adults remain largely unknown. (2) Methods: this study examined the hemodynamic activation patterns of the prefrontal and occipital cortices of 12 participants (5 male, Mage = 47.80, SDage = 17.79, range 25 to 74, and 7 female, Mage = 39.00, SDage = 18.18, range 21 to 65) passively viewing videos from three urban sites in Singapore (Urban Park, Neighborhood Landscape and City Center) at two different time points-T1, before the COVID-19 pandemic and T2, soon after the lockdown was over. (3) Results: We observed a significant and marginally significant decrease in average oxyhemoglobin (Oxy-Hb) over time for each of the visual conditions. For both green spaces (Urban Park and Neighborhood Landscape), the decrease was in the visual cortex, while for the City Center with no green elements, the marginal decrease was observed in the visual cortex and the frontal eye fields. (4) Conclusions: The results suggest that the COVID-19-related lockdown experienced by urban inhabitants may have contributed to decreased brain hemodynamics, which are further related to a heightened risk of mental health disorders, such as depression or a decline in cognitive functions. Moreover, the busy City Center scenes induced a hemodynamic pattern associated with stress and anxiety, while urban green spaces did not cause such an effect. Urban green scenes can be an important factor to offset the negative neuropsychological impact of busy urban environments post-pandemic.

DOI： 10.3390/ijerph18116118

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Neural mismatch response resulting from the difference between prediction and observation is related to change detection and discrimination. Robust neuromagnetic brain activity of auditory mismatch-related perception occurs in response to non-prototypical vowels in across-category contrasts for first-language speakers. However, whether this non-prototypicality effect applies to within-category vowel perception remains to be elucidated. Here, healthy Japanese adults (n = 7) were subjected to magnetoencephalography (MEG) while watching a silent movie, and passively listened to synthesized English vowels /i/. We observed the source-level mismatch effect to the mid-high near-front vowel deviant [ɪ] with the most non-prototypical, unspecified feature in the participants' native language system. The mismatch effect recruited the left posterior superior temporal sulcus with a peak latency of 225 ms post-stimulus onset. We further studied whether a longer F1 distance between vowel pairs would increase mismatch-activated intensities, however, we did not observe neuromagnetic changes when the prototypical anchor standard [i] was compared with three non-prototypical deviants differing in first resonance frequency (F1) values. Our results indicate that an F1 increase in within-category upper front vowel perception is a strong activator of mismatch responses measured by source-level activated intensities for non-native listeners.

DOI： 10.1007/s00221-020-05996-4

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担当区分：筆頭著者   記述言語：英語  

[This corrects the article DOI: 10.1117/1.NPh.8.1.012101.].

DOI： 10.1117/1.NPh.8.1.019802

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/jts.22628

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00221-020-05872-1

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnins.2020.00694

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Significance: It has been reported that children with attention-deficit hyperactivity disorder (ADHD) have impairment in the recognition of angry but not of happy facial expressions, and they show atypical cortical activation patterns in response to facial expressions. However, little is known about neural mechanisms underlying the impaired recognition of facial expressions in school-aged children with ADHD and the effects of acute medication on their processing of facial expressions. Aim: We aimed to investigate the possibility that acute administration of methylphenidate (MPH) affects processing of facial expressions in ADHD children. Approach: We measured the hemodynamic changes in the bilateral temporo-occipital areas of ADHD children observing the happy and angry facial expressions before and 1.5 h after MPH or placebo administration in a randomized, double-blind, placebo-controlled, crossover design study. Results: We found that, regardless of medication, happy expressions induced increased oxyhemoglobin (oxy-Hb) responses in the right inferior occipital region but not in the superior temporal region. For angry expressions, oxy-Hb responses increased after MPH administration, but not after placebo administration, in the left inferior occipital area, whereas there was no significant activation before MPH administration. Conclusions: Our results suggest that (1) ADHD children consistently recruit the right inferior occipital regions to process happy expressions and (2) MPH administration to ADHD children enhances cortical activation in the left inferior occipital regions when they process angry expressions.

DOI： 10.1117/1.NPh.7.2.025003

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnhum.2020.00003

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.dcn.2019.100701

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.6.4.045013

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/joss.12498

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnhum.2019.00007

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.5.4.045001

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/jpr.12218

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ijgfs.2018.05.005

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/jpr.12204

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/jpr.12194

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.5.3.035008

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掲載種別：研究論文（国際会議プロシーディングス）  

DOI： 10.5194/isprs-archives-XLII-2-463-2018

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2017.12.091

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.4172/neuropsychiatry.1000418

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2017.12.003

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnhum.2018.00062

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1080/15256480.2017.1324341

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1155/2018/3572397

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fnins.2017.00394

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2016.08.011

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jneumeth.2016.02.024

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2015.09.062

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.foodqual.2015.06.007

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/hbm.22885

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.2.2.025003

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.2.2.020801

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1117/1.NPh.2.1.015002

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2014.04.067

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2013.12.062

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neures.2014.01.003

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The present study explored the possibility of generating a novel sensory evaluation instrument for describing comprehensive food palatability via its subdomains (rewarding, cultural, and informational) while keeping physiological factors constant. Seventy-five Japanese participants were asked to taste cheese samples and to respond to a questionnaire that was developed to dissect the distinct subdomains of palatability. The subsequent factor analyses revealed that three major factors may serve as distinct subdomains of palatability: rewarding, cultural, and informational, although the informational factor was not sufficiently robust. Multivariate regression analysis on cheese samples with exactly the same ingredients but sold in different packages led to different comprehensive palatability ratings due to the contribution of the cultural, but not the rewarding, factor. These results suggest that palatability is not merely determined by the physical and chemical properties that are intrinsic to a food product itself, but also depends on psychological properties that can arise through interaction between humans and the food product. The current study presents the first experimental demonstration that palatability could be dissociated to its subdomains.

DOI： 10.1002/fsn3.48

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.bandl.2013.05.007

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0068474

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/hbm.21453

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.semcdb.2012.11.001

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/chemse/bjs137

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jneumeth.2012.09.027

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neurobiolaging.2011.12.022

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/j.1468-5884.2012.00511.x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley-Blackwell  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2012.05.031

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/1472-6947-12-104

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：IEEE  

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.bandl.2012.02.001

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.clinph.2011.10.006

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.appet.2012.02.013

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.foodqual.2011.10.002

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.foodqual.2011.09.007

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neures.2011.10.008

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/cercor/bhr023

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.visres.2011.05.016

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/j.1750-3841.2011.02047.x

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neures.2010.09.003

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2010.08.016

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/1471-2342-11-3

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.foodqual.2010.05.002

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.foodqual.2010.05.010

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.appet.2010.06.013

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevir  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2009.12.023

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We investigated the effect that the parameters of luminance distribution in fresh food have on our visual perception of its freshness. We took pictures of the degradation over 32 h in freshness of a cabbage. We used original images, which were patches of the pictures taken at different sampling hours, and artificially generated pictures, called "matched images," created by fitting the luminance histogram shape of the original image (taken at the 1st hour) to those at various freshness stages using a luminance histogram-matching algorithm. Nine participants rated the perceived freshness of the original and the matched images on a scale of degradation. As a result, we found that the participants could quantitatively estimate the degradation in freshness of the cabbage simply by looking at the presented images. Some parameters of the luminance histograms monotonically change with decreasing freshness, indicating that the freshness of cabbage can be estimated using these parameters. However, the freshness ratings for the matched images after the 8th hour of degradation had lower modification than those for the respective original images. These results suggest that the luminance distribution in the vegetable texture partly contributes to visual freshness perception but other variables, such as spatial patterns, might also be important for estimating visual freshness.

DOI： 10.1016/j.appet.2010.01.002

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jecp.2009.11.002

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2009.07.033

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記述言語：英語  

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.clinph.2009.01.023

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.appet.2008.11.002

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/chemse/bjn075

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jecp.2008.07.002

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neulet.2008.12.016

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/cercor/bhn081

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.appet.2008.05.054

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/jcb.21809

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.brainres.2008.05.079

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2007.12.037

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：The Japanese Psychonomic Society  

We examined whether simultaneous illusory thermal sensations can influence the perception of hardness. By applying thermal stimuli on the index and ring fingers, we elicited referred thermal sensation on the middle finger, to which only hardness stimuli was applied without affecting the thermal properties of the peripheral receptors. Seven participants underwent a two-alternative forced-choice task on the perceived hardness of rubber pieces with various hardness values. The results show that the participants found samples to be harder under the cold condition. This phenomenon implies that the illusory thermal experience induces a tactile illusion in which warm (cold) material is perceived to be soft (hard).

DOI： 10.14947/psychono.KJ00005084888

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.physbeh.2007.05.006

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1109/ICCME.2007.4381881

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1263/jbb.103.207

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記述言語：英語   出版者・発行元：Int. Res. Promotion Council  

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2006.06.047

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.appet.2006.04.003

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.neuroimage.2005.12.021

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

It is important to create a link between stereotaxic coordinates and head-surface-based positioning systems in order to share data between tomographic and transcranial brain mapping studies. In our previous studies, we established the probabilistic correspondence of the international 10-20 positions to the standard stereotaxic coordinate systems and made a reference database. However, its expansion required the physical marking of the 10-20 positions and the subsequent acquisition of MR images. To avoid such tedious procedures, we developed a virtual 10-20 measurement algorithm that can be applied to re-analyze any structural MR image that covers the whole head. As in the physical 10-20 measurements, with the reference points given, the algorithm automatically determines each 10-20 position step by step. Using the virtual 10-20 measurement method, we re-analyzed the MR images of 17 healthy subjects for whom we had determined 10-20 positions by physical marking in our previous study. The acquired 10-20 positions were normalized to the Montreal Neurological Institute (MNI) stereotactic coordinates and compared with the positions previously determined by physical measurements. 10-20 positions determined using the virtual and physical methods were roughly consistent. Average standard deviations for virtual and physical methods were 7.7 mm and 9.0 mm, respectively. There was a systematic shift in the virtual method, likely due to the absence of hair interference. We corrected the shift with affine transformation. The virtual 10-20 measurement method proved to be an effective alternative to physical marking. This method will serve as an essential tool for expanding the reference database and will further strengthen the link between tomographic and transcranial brain mapping methods.

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Recent advancements in two noninvasive transcranial neuroimaging techniques, near-infrared spectroscopy (NIRS) and transcranial magnetic stimulation (TMS), signify the increasing importance of establishing structural compatibility between transcranial methods and conventional tomographic methods, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). The transcranial data obtained from the head surface should be projected onto the cortical surface to present the transcranial brain-mapping data on the same platform as tomographic methods. Thus, we developed two transcranial projection algorithms that project given head-surface points onto the cortical surface in structural images, and computer programs based on them. The convex-hull algorithm features geometric handling of the cortical surface, while the balloon-inflation algorithm is faster, and better reflects the local cortical structure. The automatic cortical projection methods proved to be as effective as the manual projection method described in our previous study. These methods achieved perfect correspondence between any given point on the head surface or a related nearby point in space, and its cortical projection point. Moreover, we developed a neighbor-reference method that enables transcranial cortical projection of a given head-surface point in reference to three neighboring points and one additional standard point, even when no structural image of the subject is available. We also calculated an error factor associated with these probabilistic estimations. The current study presents a close topological link between transcranial and tomographic brain-mapping modalities, which could contribute to inter-modal data standardization.

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Signaling through the T cell antigen receptor leading to elimination (negative selection) or differentiation (positive selection) of developing thymocytes generates a self-tolerant T cell repertoire. Here we report that the serine-threonine kinase MINK selectively connects the T cell receptor to a signaling pathway that mediates negative but not positive selection. Analysis of this pathway suggested that the essential function of MINK in the elimination of self-reactive thymocytes may be associated with 'downstream' activation of Jun kinase and enhancement of expression of the proapoptotic molecule Bim.

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

An intriguing application of neuroimaging is directly measuring actual human brain activities during daily living. To this end, we investigated cortical activation patterns during apple peeling. We first conducted a pilot study to assess the activation pattern of the whole lateral cortical surface during apple peeling by multichannel near-infrared spectroscopy (NIRS) and detected substantial activation in the prefrontal region in addition to expected activations extending over the motor, premotor and supplementary motor areas. We next examined cortical activation during mock apple peeling by simultaneous measurement using multichannel NIRS and functional magnetic resonance imaging (fMRI) in four subjects. We detected activations extending over the motor, premotor and supplementary motor areas, but not in the prefrontal cortex. Thus, we finally focused on the prefrontal cortex and examined its activation during apple peeling in 12 subjects using a multichannel NIRS. We subsequently found that regional concentrations of oxygenated hemoglobin significantly increased in the measured region, which encompassed portions of the dorsolateral, ventrolateral and frontopolar areas of the prefrontal cortex. The current study demonstrated that apple peeling as practiced in daily life recruited the prefrontal cortex but that such activation might not be detected for less laborious mock apple peeling that can be performed in an fMRI environment. We suggest the importance of cortical study of an everyday task as it is but not as a simplified form; we also suggest the validity of NIRS for this purpose. Studies on everyday tasks may serve as stepping stone toward understanding human activities in terms of cortical activations.

PubMed

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掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/j.1745-4603.2003.tb01078.x

Scopus

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Overlapping of genes, especially in an anti-parallel fashion, is quite rare in eukaryotic genomes. We have found a rare instance of exon overlapping involving CHRNE and MINK gene loci on chromosome 17 in humans. CHRNE codes for the epsilon subunit of the nicotinic acetylcholine receptor (AChRepsilon) whereas MINK encodes a serine/threonine kinase belonging to the GCK family. To elucidate the evolutionary trail of this gene overlapping event, we examined the genomes of a number of primates and found that mutations in the polyadenylation signal of the CHRNE gene in early hominoids led to the overlap. Upon extending this analysis to genomes of other orders of placental mammals, we observed that the overlapping occurred at least three times independently during the course of mammalian evolution. Because CHRNE and MINK are differentially expressed, the potentially hazardous mutations responsible for the exon overlap seem to have escaped evolutionary pressures by differential temporo-spatial expression of the two genes.

PubMed

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/sj.onc.1205478

Scopus

PubMed

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1074/jbc.M110882200

Scopus

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s002890200008

Scopus

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担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/S0014-5793(00)01247-3

Scopus

PubMed

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記述言語：日本語   著書種別：学術書

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記述言語：日本語   出版者・発行元：(公社)日本心理学会  

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：英語  

DOI： 10.1111/jpr.12230

Web of Science

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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出版者・発行元：InTech  

DOI： 10.5772/intechopen.71835

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：英語  

DOI： 10.1117/12.2249742

Web of Science

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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J-GLOBAL

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：日本語   出版者・発行元：日本薬物脳波学会  

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：日本語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：日本語   出版者・発行元：認知神経科学会  

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本体力医学会  

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記述言語：日本語   出版者・発行元：(一社)日本臨床神経生理学会  

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記述言語：日本語   出版者・発行元：(一社)日本抗加齢医学会  

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記述言語：英語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：英語   出版者・発行元：The UK Embassy of Tokyo, and The Royal Society  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（その他）   出版者・発行元：厚生労働省  

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記述言語：日本語  

Functional near-infrared spectroscopy (fNIRS) may be suited for functional monitoring during swallowing as it is comparatively immune to body movement. However, still fNIRS measurement on swallowing poses a technical problem that it may often involve motion artifacts. Although there is no single way to solve this problem, technical insights have been available form related studies in the past. Here we introduce two examples for analyzing data rich in motion artifacts putting emphasis on temporal structures of the data. The first is about fNIRS assessment of language function during overt naming tasks. Since data were temporally continuous, we adopted a general linear model with regression to a canonical hemodynamic response function to extract cortical activations related to overt naming tasks. The second example is about fNIRS assessment on go/no-go task performance with or without methylphenidate administration in Attention Deficit Hyperactivity Disorder (ADHD) children. Since data were disrupted by unexpected motion artifacts, we simplified temporal data structures by averaging to extract only robust signals. Thus, we indicated that the optimum analytical strategy varies depending on the temporal structures of the data.

PubMed

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J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本体力医学会  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（その他）   出版者・発行元：農林水産省  

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記述言語：日本語   出版者・発行元：日本大学医学会  

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記述言語：日本語   出版者・発行元：FFIジャーナル編集委員会  

CiNii Books

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記述言語：日本語   出版者・発行元：(一社)日本小児神経学会  

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記述言語：日本語   出版者・発行元：財団法人 生存科学研究所  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

DOI： 10.1016/j.neures.2011.07.892

Web of Science

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記述言語：英語   出版者・発行元：Organization for Human Brain Mepping  

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記述言語：日本語   出版者・発行元：日本体育学会  

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記述言語：日本語   出版者・発行元：日本体育学会  

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記述言語：日本語   出版者・発行元：日本医用画像工学会  

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記述言語：日本語   出版者・発行元：日本基礎心理学会  

DOI： 10.14947/psychono.KJ00006393807

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（その他）   出版者・発行元：厚生労働省  

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記述言語：英語  

DOI： 10.1007/978-1-4419-1241-1_29

Web of Science

PubMed

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記述言語：日本語   出版者・発行元：放射線科学  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：日本語   出版者・発行元：フレグランスジャーナル社  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2009243392

記述言語：日本語   出版者・発行元：食品総合研究所  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（その他）   出版者・発行元：厚生労働省  

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：日本語   出版者・発行元：日本基礎心理学会  

DOI： 10.14947/psychono.KJ00005578274

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記述言語：日本語   出版者・発行元：全国清涼飲料工業会  

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記述言語：日本語   出版者・発行元：(一社)日本臨床神経生理学会  

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記述言語：英語   出版者・発行元：Pacific Rim College of Psychiatrists  

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記述言語：日本語   出版者・発行元：日本基礎心理学会  

DOI： 10.14947/psychono.KJ00004902546

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：日本語   出版者・発行元：認知神経科学会  

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記述言語：日本語   出版者・発行元：光琳  

J-GLOBAL

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記述言語：日本語   出版者・発行元：シーエムシー出版社  

CiNii Books

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記述言語：日本語   出版者・発行元：食品化学新聞社  

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記述言語：日本語   出版者・発行元：認知神経科学会  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2008159232

記述言語：日本語   出版者・発行元：(一社)日本体力医学会  

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記述言語：日本語   出版者・発行元：日本味と匂学会  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2008064685

記述言語：日本語   出版者・発行元：日本分析化学会  

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2008047882

記述言語：日本語   出版者・発行元：日本認知神経科学会  

【要旨】光トポグラフィは頭表上に設置したプローブから脳の活性状態を血流変化として計測する方法である。しかし、光トポグラフィの測定プローブは頭表上に置かれるため、補助的撮像を使わなければ、脳のどこを測っているのかが分からないという問題があった。これを解決するために、光トポグラフィのみで脳活動データの空間解析が行える方法として、頭の上からその下にある脳の位置を確率的に推定する、「確率的レジストレーション法」を開発した。その結果は、標準脳座標系上の座標値として表現され、推定精度は概ね1cm以内である。これによって、光トポグラフィと他の脳機能研究手法による脳機能計測データの相互参照が可能となる。

DOI： 10.11253/ninchishinkeikagaku1999.9.13

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

DOI： 10.1016/j.neures.2007.06.135

Web of Science

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

DOI： 10.1016/j.neures.2007.06.602

Web of Science

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

DOI： 10.1016/j.neures.2007.06.540

Web of Science

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記述言語：英語  

Web of Science

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記述言語：英語  

DOI： 10.1109/ICCME.2007.4382102

Web of Science

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記述言語：日本語   出版者・発行元：日本味と匂学会  

CiNii Books

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記述言語：日本語   出版者・発行元：オーム社  

CiNii Books

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記述言語：日本語   出版者・発行元：オーム社  

CiNii Books

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（その他）   出版者・発行元：食品総合研究所  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（その他）   出版者・発行元：食品総合研究所  

J-GLOBAL

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

Web of Science

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記述言語：日本語   出版者・発行元：食品総合研究所  

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記述言語：日本語   出版者・発行元：羊土社  

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記述言語：日本語   出版者・発行元：羊土社  

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記述言語：日本語   出版者・発行元：羊土社  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（その他）   出版者・発行元：朝日新聞社  

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記述言語：英語  

PubMed

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記述言語：日本語   出版者・発行元：物性研究刊行会  

哺乳類の大脳神経回路網形成で最も重要な過程は「1余剰な神経細胞,シナプスの産生」,「2高感受性期における活動依存的神経回路の選抜」,「3低感受性期への移行」である.この過程を支える分子機構を明らかにする第一歩として,生後マウスの大脳において時期特異的に発現する遺伝子の検出を試みた.まず新しい遺伝子発現比較法の開発に着手し,この結果,Poly(A)^+ mRNA fingerprinting by arbitrary primers (PRAP)法という新しいDifferential display (DD)型遺伝子発現比較法を開発した.PRAP法で得られる遺伝子断片は,mRNAの3'末端非翻訳領域を選択的には増幅せず,翻訳領域の配列情報を高確率で入手することができるようになった.さらに,従来のDD型遺伝子発現比較法全てに対して適応可能な遺伝子検索の確率論的基盤を整備した.次にPRAP法を用いて生後0,1,2,4,6週齢のマウス大脳における遺伝子発現を比較し,発現に差の見られたいくつかの遺伝子断片についてノーザンブロット解析と塩基配列決定を試みた.パイロット研究の結果,相同性をもった複数種のGタンパクが,生後のマウス大脳において,時期特異的に発現していることが示された.

CiNii Books

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その他リンク： http://dl.ndl.go.jp/info:ndljp/pid/10938441

記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：英語   会議種別：口頭発表（一般）  

researchmap

記述言語：英語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：英語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap

記述言語：日本語   会議種別：口頭発表（一般）  

researchmap