Updated on 2024/02/15

写真a

 
TAKEUCHI Ayano
 
Organization
Faculty of Science and Engineering Associate Professor
Other responsible organization
Civil, Human and Environmental Science and Engineering Course of Graduate School of Science and Engineering, Master's Program
Profile
Epidemiology and Biostatisticsi
External link

Degree

  • 博士(保健学) ( 東京大学 )

  • 修士(保健学) ( 東京大学 )

Education

  • 2008.3
     

    The University of Tokyo   doctor course   withdrawn before completion

  • 2006.3
     

    The University of Tokyo   master course   completed

  • 2004.3
     

    The University of Tokyo   others   graduated

  • 2002.3
     

    The University of Tokyo   others   completed

Research History

  • 2022.4 -  

    中央大学理工学部准教授

  • 2016.4 - 2022.3

    慶應義塾大学医学部衛生学公衆衛生学教室 専任講師

  • 2014.10 - 2016.3

    慶應義塾大学医学部衛生学公衆衛生学教室 助教

  • 2012.5 - 2014.9

    独立行政法人国立環境研究所環境健康研究センター研究員   環境健康研究センター環境疫学   研究員

  • 2008.4 - 2012.4

    The University of Tokyo   医学系研究科公共健康医学専攻生物統計学   助教

  • 2008.4 - 2012.4

    東京大学大学院医学系研究科健康科学看護学専攻/東京大学大学院情報学環 助教   医学系研究科公共健康医学専攻生物統計学   助教

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Professional Memberships

  • 日本計量生物学会

  • 日本疫学会

  • 日本衛生学会

  • 日本公衆衛生学会

  • 日本産業衛生学会

  • 日本看護科学学会

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Research Interests

  • Biostatistics

Research Areas

  • Informatics / Statistical science

  • Life Science / Hygiene and public health

  • Life Science / Medical management and medical sociology  / Epidemiology and preventive medicine

  • Life Science / Hygiene and public health

  • Environmental Science/Agriculture Science / Environmental impact assessment  / Environmental impact assessment

Papers

  • Accumulated unhealthy behaviours and insomnia in Japanese dwellers with and without cardiovascular risk factors: a cross-sectional study. Reviewed International journal

    Kato S, Harada S, Iida M, Kuwabara K, Sugiyama D, Takeuchi A, Sata M, Matsumoto M, Kurihara A, Hirata A, Okamura T, Takebayashi T

    BMJ open   12 ( 4 )   e052787   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BMJ open  

    OBJECTIVES: To date, the association between accumulated unhealthy behaviours and insomnia in individuals stratified according to the presence or absence of major cardiovascular risk factors is unclear. This study aimed to examine the effect of accumulated unhealthy behaviours on insomnia in Japanese dwellers. DESIGN: Cross-sectional study. SETTING: Baseline data between April 2012 and March 2015. PARTICIPANTS: Our study used cross-sectional data among Japanese aged 35-74 years in a rural community (N=9565), the attendees of annual municipal or work site health check-up programmes. MAIN OUTCOME MEASURES: Insomnia was assessed by Athens Insomnia Scale, which was set at 6 points and greater; other scales were given. Participants were categorised into three groups by their number of unhealthy behaviours (no exercise habit, smoking, alcohol drinking, skipping breakfast and obesity): 0-1, 2-3, 4 or more. The association between accumulated unhealthy behaviours and insomnia was estimated by logistic regression analysis. Further analysis was done after stratification of cardiovascular risk factors assessed by anthropometrics and clinical biochemistry measurements. RESULTS: The overall prevalence of insomnia was 13.3% for men and 19.3% for women. Men with unhealthy behaviour factors were more likely to have insomnia after adjusting for potential confounders, compared with the least unhealthy group (trend p=0.013). Women with four or more unhealthy behaviour factors were more likely to have insomnia, compared with the lowest groups (OR 1.175, 95% CI 1.077 to 1.282). Insomnia has an association with the unhealthy behaviours among men without cardiovascular risk factors (lowest groups: OR 1.133, 95% CI 1.037 to 1.238, trend p=0.026). Women without hypertension were more likely to have suspected insomnia, compared with the lowest group (OR 1.215, 95% CI 1.101 to 1.341). CONCLUSION: The results showed accumulated unhealthy behaviours were associated with increased risk of insomnia in Japanese dwellers. For healthy population without cardiovascular risk factors, unhealthy behaviours should be considered as background conditions for insomnia.

    DOI: 10.1136/bmjopen-2021-052787

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  • Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

    Yoshiki Ishibashi, Sei Harada, Ayano Takeuchi, Miho Iida, Ayako Kurihara, Suzuka Kato, Kazuyo Kuwabara, Aya Hirata, Takuma Shibuki, Tomonori Okamura, Daisuke Sugiyama, Asako Sato, Kaori Amano, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Toru Takebayashi

    Scientific Reports   11 ( 1 )   2021.12

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    <title>Abstract</title>Currently, large-scale cohort studies for metabolome analysis have been launched globally. However, only a few studies have evaluated the reliability of urinary metabolome analysis. This study aimed to establish the reliability of urinary metabolomic profiling in cohort studies. In the Tsuruoka Metabolomics Cohort Study, 123 charged metabolites were identified and routinely quantified using capillary electrophoresis-mass spectrometry (CE-MS). We evaluated approximately 750 quality control (QC) samples and 6,720 participants’ spot urine samples. We calculated inter- and intra-batch coefficients of variation in the QC and participant samples and technical intraclass correlation coefficients (ICC). A correlation of metabolite concentrations between spot and 24-h urine samples obtained from 32 sub-cohort participants was also evaluated. The coefficient of variation (CV) was less than 20% for 87 metabolites (70.7%) and 20–30% for 19 metabolites (15.4%) in the QC samples. There was less than 20% inter-batch CV for 106 metabolites (86.2%). Most urinary metabolites would have reliability for measurement. The 96 metabolites (78.0%) was above 0.75 for the estimated ICC, and those might be useful for epidemiological analysis. Among individuals, the Pearson correlation coefficient of 24-h and spot urine was more than 70% for 59 of the 99 metabolites. These results show that the profiling of charged metabolites using CE-MS in morning spot human urine is suitable for epidemiological metabolomics studies.

    DOI: 10.1038/s41598-021-86600-9

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    Other Link: http://www.nature.com/articles/s41598-021-86600-9

  • Changes in smoking habits and behaviors following the introduction and spread of heated tobacco products in Japan and its effect on FEV1 decline: a longitudinal cohort study. Reviewed

    Harada S, Sata M, Matsumoto M, Iida M, Takeuchi A, Kato S, Hirata A, Kuwabara K, Shibuki T, Ishibashi Y, Sugiyama D, Okamura T, Takebayashi T

    Journal of epidemiology   32 ( 4 )   180 - 187   2021.10

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    BACKGROUND: Heated tobacco product (HTP) use in Japan has rapidly increased. Despite this rapid spread, little is known about the health effects of HTP use. We conducted a longitudinal cohort study to investigate the change in smoking habits following the spread of HTP use and its effect on forced expiratory volume in 1 second (FEV1) decline. METHODS: Participants consisted of a resident population (n = 2,612; mean age, 67.7 years) with FEV1 measurement in 2012-2014 and 2018-2019, and a worksite population (n = 722; mean age 49.3 years) without FEV1 data. Participants were categorized as combustible cigarette-only smokers, HTP-only users, dual users, past smokers, and never smokers. The association between smoking group and the change in smoking consumption over a mean 5.6 years was examined. Differences in annual FEV1 change between smoking groups were examined in the resident population. RESULTS: Prevalence of HTP-only and dual users in 2018-2019 was 0.8% and 0.6% in the resident population, and 5.0% and 1.9% in the worksite population, respectively. The overall number of tobacco products smoked/used increased in dual users compared to baseline, but not in others. Annual FEV1 decline in dual users tended to be greater than that in cigarette-only smokers (16; 95% confidence interval, -34 to 2 mL/year after full adjustment). Participants switching to HTP-only use 1.7 years before had a similar FEV1 decline as cigarette-only smokers. CONCLUSIONS: HTP use, including dual use, is prevalent even in a rural region of Japan. Dual users appear to smoke/use tobacco products more and have a greater FEV1 decline. Tobacco policy should consider dual use as high-risk.

    DOI: 10.2188/jea.JE20210075

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  • Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study (vol 15, e0238723, 2020)

    Ishibashi, Yoshiki, Nishitani, Rie, Shimura, Akiyoshi, Takeuchi, Ayano, Touko, Mamoru, Kato, Takashi, Chiba, Sahoko, Ashidate, Keiko, Ishiwata, Nobuo, Ichijo, Tomoyasu, Sasabe, Masataka

    PLOS ONE   16 ( 10 )   2021.10

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  • Erratum to "Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims" [J Epidemiol 31 (9) (2021) 495-502].

    Minako Matsumoto, Sei Harada, Miho Iida, Suzuka Kato, Mizuki Sata, Aya Hirata, Kazuyo Kuwabara, Ayano Takeuchi, Daisuke Sugiyama, Tomonori Okamura, Toru Takebayashi

    Journal of epidemiology   31 ( 9 )   520 - 521   2021.9

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    DOI: 10.2188/jea.JE20210109

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  • Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims.

    Minako Matsumoto, Sei Harada, Miho Iida, Suzuka Kato, Mizuki Sata, Aya Hirata, Kazuyo Kuwabara, Ayano Takeuchi, Daisuke Sugiyama, Tomonori Okamura, Toru Takebayashi

    Journal of epidemiology   31 ( 9 )   495 - 502   2021.9

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    BACKGROUND: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the validity of a self-reported questionnaire on medication use by comparison with health insurance claims and to identify individual determinants of discordance in the Tsuruoka Metabolomics Cohort Study. METHODS: Participants were 2,472 community-dwellers aged 37 to 78 years from the Tsuruoka Metabolomics Cohort Study. Information on lifestyle and medications was collected through a questionnaire. Sensitivity and specificity were determined using health insurance claims from November 2014 to March 2016, which were used as a standard. Potential determinants of discordance were assessed using multivariable logistic regression. RESULTS: The self-reported questionnaire on medication use showed high validity. Sensitivity and specificity were 0.95 (95% CI, 0.93-0.96) and 0.97 (95% CI, 0.96-0.98) for antihypertensive medications, 0.94 (95% CI, 0.91-0.97) and 0.98 (95% CI, 0.98-0.99) for diabetes medications, and 0.84 (95% CI, 0.82-0.87) and 0.98 (95% CI, 0.97-0.99) for dyslipidemia medications, respectively. Males without high education and those who currently smoke cigarettes were found to be associated with discordant reporting which affected sensitivity, especially those with medication use for dyslipidemia. CONCLUSIONS: In this population-based cohort study, we found that the self-reported questionnaire on medication use was a valid measure to capture regular medication users. Sensitivity for dyslipidemia medications was lower than those for the other medications. Type of medication, sex, education years, and smoking status influenced discordance, which affected sensitivity in self-reporting.

    DOI: 10.2188/jea.JE20200089

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  • Change of smoking habits by introducing and spreading heated tobacco products in Japan

    Harada, Sei, Sata, Mizuki, Matsumoto, Minako, Takeuchi, Ayano, Iida, Miho, Kato, Suzuka, Hirata, Aya, Kuwabara, Kazuyo, Sugiyama, Daisuke, Okamura, Tomonori, Takebayashi, Toru

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY   50   93 - 93   2021.9

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    DOI: 10.1093/ije/dyab168.261

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  • チームで構築した腎移植レシピエントの栄養管理

    吉田 朋子, 石井 大輔, 野口 文乃, 井村 夕姫, 森岡 優子, 阿部 哲也, 北島 和樹, 竹内 康雄, 吉田 一成

    日本臨床腎移植学会雑誌 = Journal of Japanese Society for Clinical Renal Transplantation   9 ( 1 )   23 - 29   2021.7

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  • EFFECT OF ACCUMULATED UNHEALTHY BEHAVIORS ON INSOMNIA(A)over-cap(SIC).LIFESTYLE-RELATED DISEASE DIFFERENCES IN A JAPANESE COMMUNITY POPULATION

    Kato, Suzuka, Harada, Sei, Iida, Miho, Kuwabara, Kazuyo, Sugiyama, Daisuke, Takeuchi, Ayano, Hirata, Aya, Sata, Mizuki, Matsumoto, Minako, Kurihara, Ayako, Okamura, Tomonori, Takebayashi, Toru

    SLEEP   44   A128 - A128   2021.5

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  • Association of the Estimated Coronary Artery Incidence Risk According to the Japan Atherosclerosis Society Guidelines 2017 with Cardio-Ankle Vascular Index.

    Mizuki Sata, Tomonori Okamura, Sei Harada, Daisuke Sugiyama, Kazuyo Kuwabara, Aya Hirata, Ayano Takeuchi, Miho Iida, Suzuka Kato, Minako Matsumoto, Ayako Kurihara, Toru Takebayashi

    Journal of atherosclerosis and thrombosis   28 ( 12 )   1266 - 1274   2021.3

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    AIMS: The categories in the comprehensive lipid and risk management guidelines were proposed by the Japan Atherosclerosis Society (JAS Guidelines 2017), which adopted the estimated 10 year absolute risk of coronary artery disease (CAD) incidence in the Suita score. We examined whether those categories were concordant with the degree of arterial stiffness. METHODS: In 2014, the cardio-ankle vascular index (CAVI), an arterial stiffness parameter, was measured in 1,972 Japanese participants aged 35-74 years in Tsuruoka City, Yamagata Prefecture, Japan. We examined the mean CAVI and the proportion and odds ratios (ORs) of CAVI ≥ 9.0 on the basis of the following three management classifications using the analysis of variance and logistic regression: "Category I (Low risk)," "Category II (Middle risk)," and "Category III (High risk)." RESULTS: The mean CAVI and proportion of CAVI ≥ 9.0 were 8.6 and 34.8% among males and 8.1 and 18.3% among females, respectively. The mean CAVI and proportion of CAVI ≥ 9.0 were associated with an estimated 10 year absolute risk for CAD among males and females, excluding High risk for females. These results were similar to the management classification by the guideline: the multivariable-adjusted ORs (95% confidence intervals) of CAVI ≥ 9.0 among Category II and Category III compared with those among Category I were 2.96 (1.61-5.43) and 7.33 (4.03-13.3) for males and 3.99 (2.55-6.24) and 3.34 (2.16-5.16) for females, respectively. CONCLUSIONS: The risk stratification, which was proposed in the JAS Guidelines 2017, is concordant with the arterial stiffness parameter.

    DOI: 10.5551/jat.58719

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  • Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines. International journal

    Makiko Nakano, Takafumi Shinagawa, Yoko Eitaki, Kazuyuki Omae, Ayano Takeuchi, Satoko Iwasawa, Kota Fukai, Noriyuki Yoshioka, Shigeru Tanaka, Shigeki Koda, Tomotaka Sobue, Toru Takebayashi

    International archives of occupational and environmental health   94 ( 6 )   1427 - 1439   2021.3

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    PURPOSE: Nine bladder cancer (BCa) cases were reported among aromatic amine-exposed male workers at a factory manufacturing organic dye/pigment intermediates in Japan. We aimed to evaluate the characteristics of aromatic amine-exposed workers by cross-sectional observation, and the risk of BCa by assessing the standardized incidence ratio (SIR). METHODS: In the cross-sectional study, our subjects were: 9 BCa patients, 36 aromatic amine-exposed non-patients, and 79 non-exposed workers from 3 factories. We evaluated the subjects' medical history, urinalysis, qualitative determination of nuclear matrix protein 22, and urinary cytology. For SIR assessment, 98 aromatic amine-exposed workers from 1 factory were included, and the Japanese general male population was used as a referent population. Since no direct aromatic amine-exposure data were available, we calculated surrogate exposure levels using information on job sites, exposure potency, and duration. RESULTS: Coexistent aromatic amines were ortho-toluidine (OT), aniline, para-toluidine, ortho-anisidine, 2,4-xylidine, and ortho-chloroaniline. The prevalence rates of cystitis and bladder lesion-related symptoms in both BCa patients and aromatic amine-exposed non-patient workers were significantly higher than those of non-exposed workers. Overall, the SIR for BCa in OT-exposed workers was 56.8 (95% CI 27.7-104.3) and apparent dose-response relationships were revealed between the SIR and the surrogate exposure level in the 0-10-year lagged analyses. Overall, SIRs in other aromatic amine-exposed workers were also significantly high but no or unclear dose-response relationships were observed. CONCLUSIONS: We conclude that OT may be responsible for the increased risk of BCa. Regular monitoring of bladder lesion-related symptoms is essential for the early identification of BCa.

    DOI: 10.1007/s00420-021-01658-2

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  • Long-Term Exposure to Particulate Matter and Mortality from Cardiovascular Diseases in Japan: The Ibaraki Prefectural Health Study (IPHS).

    Ayano Takeuchi, Yuji Nishiwaki, Tomonori Okamura, Ai Milojevic, Kayo Ueda, Keiko Asakura, Toru Takebayashi, Shuichi Hasegawa, Toshimi Sairenchi, Fujiko Irie, Hitoshi Ota, Hiroshi Nitta

    Journal of atherosclerosis and thrombosis   28 ( 3 )   230 - 240   2021.3

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    AIM: To examine the association between long-term exposure to suspended particulate matter (SPM) and cardiovascular mortality in Japan after controlling for known major confounding factors among a large middle and elderly cohort study in Ibaraki Prefecture, Japan. METHODS: We followed 91,808 residents (men 34%) who undertook a national health check-up at age 40-79 years for 17 years (1993-2010). Two different exposure indices were adopted: baseline SPM concentration (in the year 1990) and average SPM concentration for the first (average of 1990 and 1995) and the second half (average of 2005 to 2009) of the study period. Sex-specific adjusted risk ratios (RRs) for cardiovascular mortality were calculated using general mixed Poisson regression models after adjusting the age, BMI, history of diabetes mellitus and hypertension, creatinine, glutamic pyruvic transaminase, total cholesterol, high-density lipoprotein cholesterol, smoking, alcohol, and temperature. The variation between seven medical administration areas was also taken into account as a random effect. RESULTS: Baseline SPM concentration was associated with an increased risk of mortality from all cardiovascular diseases, coronary artery disease, and stroke. The adjusted RRs (95% confidence interval [CI]) per 10 µg/m3 increase in SPM concentration for all cardiovascular mortality were 1.147 (1.014-1.300) for men and 1.097 (0.985-1.222) for women. The point estimate of RR was highest for non-hemorrhagic stroke in men (1.248 [0.991-1.571]), although CI overlapped the unity. The RRs seemed slightly lower in the second half than in the first half, though the CIs widened in the second half. CONCLUSION: Our results suggest that long-term exposure to SPM is associated with an increased risk of all cardiovascular mortality for men in Ibaraki, Japan.

    DOI: 10.5551/jat.54148

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  • Long-Term Exposure to Particulate Matter and Mortality from Cardiovascular Diseases in Japan: The Ibaraki Prefectural Health Study (IPHS)

    Ayano Takeuchi, Yuji Nishiwaki, Tomonori Okamura, Ai Milojevic, Kayo Ueda, Keiko Asakura, Toru Takebayashi, Shuichi Hasegawa, Toshimi Sairenchi, Fujiko Irie, Hitoshi Ota, Hiroshi Nitta

    Journal of Atherosclerosis and Thrombosis   28 ( 3 )   230 - 240   2021.3

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    DOI: 10.5551/jat.54148

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  • Effect of Asian dust on respiratory symptoms among children with and without asthma, and their sensitivity. International journal

    Hideki Hasunuma, Ayano Takeuchi, Rintaro Ono, Yuko Amimoto, Yoon Ha Hwang, Itsushi Uno, Atsushi Shimizu, Yuji Nishiwaki, Masahiro Hashizume, David J Askew, Hiroshi Odajima

    The Science of the total environment   753   141585 - 141585   2021.1

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    There has been little study on the effect of Asian dust exposure on respiratory symptoms among children who are vulnerable to environmental factors. In this panel study, we investigated the effect of Asian dust on respiratory symptoms among children with and without asthma, and their sensitivity. Children attending two elementary schools (137 total), and 23 children with asthma from cooperating medical institutions in Fukuoka prefecture were recruited. Subjects measured peak expiratory flow rate (PEF), and recorded asthma-like symptoms, cough, nasal symptoms and use of medication in a diary from April 1, 2013 to June 30, 2013. To assess exposure to Asian dust, we used Light Detection and Ranging (LIDAR) data. For the analysis of the association between Asian dust and respiratory symptoms, the case-crossover design and generalized estimating equation (GEE) models were used. Taking individual sensitivity to respiratory aggravation into consideration, the subjects were classified into three groups: children without asthma, children with asthma who do not use long-term preventive medication (CA) and children with asthma who use long-term preventive medication (CA-LTM). For CA, Asian dust exposure was significantly associated with asthma-like symptoms, with a hazard ratio of 5.17 (95%CI: 1.02=26.12) at Lag0, and the change in %maxPEF, -1.65% (95%CI:-2.82, -0.48) at Lag0. For children without asthma, a statistically significant association was found between Asian dust exposure and the change in %maxPEF, -0.56% (95%CI: -1.31, -0.08) at Lag1. However, no adverse effects were observed in CA-LTM. Temperature had significant effects on %maxPEF for three groups. Asian dust, photochemical oxidant and pollen caused simultaneously additive adverse effects on nasal symptoms for children without asthma. This study suggests the possibility that long-term preventive medication to manage asthma may suppress aggravation of respiratory symptoms due to Asian dust and may be an effective prevention.

    DOI: 10.1016/j.scitotenv.2020.141585

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  • Control of a Nosocomial Outbreak of COVID-19 in a University Hospital. International journal

    Sei Harada, Shunsuke Uno, Takayuki Ando, Miho Iida, Yaoko Takano, Yoshiki Ishibashi, Yoshifumi Uwamino, Tomoyasu Nishimura, Ayano Takeda, Sho Uchida, Aya Hirata, Mizuki Sata, Minako Matsumoto, Ayano Takeuchi, Hideaki Obara, Hirokazu Yokoyama, Koichi Fukunaga, Masayuki Amagai, Yuko Kitagawa, Toru Takebayashi, Naoki Hasegawa

    Open forum infectious diseases   7 ( 12 )   ofaa512   2020.12

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    Background: Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters of infection among high-risk individuals. Controlling this spread is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak of COVID-19 in Keio University Hospital, Japan, and its control and propose effective control measures. Methods: When an outbreak was suspected, immediate isolation and thorough polymerase chain reaction (PCR) testing of patients and health care workers (HCWs) using an in-house system, together with extensive contact tracing and social distancing measures, were conducted. Nosocomial infections (NIs) were defined as having an onset or positive test after the fifth day of admission for patients and having high-risk contacts in our hospital for HCWs. We performed descriptive analyses for this outbreak. Results: Between March 24 and April 24, 2020, 27 of 562 tested patients were confirmed positive, of whom 5 (18.5%) were suspected as NIs. For HCWs, 52 of 697 tested positive, and 40 (76.9%) were considered NIs. Among transmissions, 95.5% were suspected of having occurred during the asymptomatic period. Large-scale isolation and testing at the first sign of outbreak terminated NIs. The number of secondary cases directly generated by a single primary case found before March 31 was 1.74, compared with 0 after April 1. Only 4 of 28 primary cases generated definite secondary infection; these were all asymptomatic. Conclusions: Viral shedding from asymptomatic cases played a major role in NIs. PCR screening of asymptomatic individuals helped clarify the pattern of spread. Immediate large-scale isolation, contact tracing, and social distancing measures were essential to containing outbreaks.

    DOI: 10.1093/ofid/ofaa512

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  • Impact of Tobacco Smoking on Outcomes After Posterior Decompression Surgery in Patients With Cervical Spondylotic Myelopathy: A Retrospective Multicenter Study. International journal

    Narihito Nagoshi, Hitoshi Kono, Osahiko Tsuji, Ryoma Aoyama, Kanehiro Fujiyoshi, Yuta Shiono, Masayuki Ishikawa, Kenshi Daimon, Naobumi Hosogane, Ayano Takeuchi, Eijiro Okada, Nobuyuki Fujita, Mitsuru Yagi, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Ken Ishii, Junichi Yamane

    Clinical spine surgery   33 ( 10 )   E493-E498   2020.12

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    STUDY DESIGN: This was a case-control study. OBJECTIVE: The objective of this study was to clarify the surgical outcomes after cervical posterior decompression in patients who smoked. SUMMARY OF BACKGROUND DATA: Smoking is associated with poor outcomes in the field of spinal surgery. However, the impact of tobacco smoking on the outcomes after posterior decompression surgery has not been fully evaluated in patients with cervical spondylotic myelopathy. MATERIALS AND METHODS: In this retrospective multicenter study, 587 patients with cervical spondylotic myelopathy were enrolled at 17 institutions in Japan. Patients underwent cervical laminoplasty or laminectomy and were followed up for at least 1 year after surgery. Outcome measures were: preoperative smoking status, perioperative complications, the Japanese Orthopedic Association scale, and the Visual Analog Scale for neck pain. After adjusting for age and sex by exact matching, smoking and nonsmoking groups were compared using an unpaired t test for continuous variables or a χ test for categorical variables. RESULTS: There were 182 (31%) current smokers and 405 (69%) nonsmokers including previous smokers. After matching, 158 patients were extracted from each group. Demographic data and surgical information were almost the same between the groups. Regarding postoperative complications, there was no significant difference in the rate of surgical site infection, cerebrospinal fluid leakage, hematoma, segmental motor paralysis, or neurological deficit. However, smokers showed a significantly higher risk for delirium (3.8% vs. 0.0%, P=0.039). Smokers and nonsmokers showed comparable changes in functional recovery according to Japanese Orthopedic Association scores (3.2±2.1 vs. 3.0±2.1, P=0.425) and in neck pain reduction using the Visual Analog Scale (-1.7±3.1 vs. -1.4±2.8, P=0.417) at the final follow-up. CONCLUSIONS: Smokers exhibited functional restoration and neck pain reduction after cervical posterior decompression. Attention is required, however, for the postoperative complication of delirium, which could be caused by the acute cessation of tobacco smoking after admission. LEVEL OF EVIDENCE: Level III.

    DOI: 10.1097/BSD.0000000000000984

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  • Association of blood cadmium levels in pregnant women with infant birth size and small for gestational age infants: The Japan Environment and Children's study. International journal

    Hidekuni Inadera, Ayako Takamori, Kenta Matsumura, Akiko Tsuchida, Zheng-Guo Cui, Kei Hamazaki, Tomomi Tanaka, Mika Ito, Mika Kigawa, Hideki Origasa, Takehiro Michikawa, Shoji F Nakayama, Tomohiko Isobe, Ayano Takeuchi, Tosiya Sato, Hiroshi Nitta, Shin Yamazaki

    Environmental research   191   110007 - 110007   2020.12

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    BACKGROUND: There is growing evidence of an association between cadmium (Cd) and unfavorable birth outcomes. The effect of Cd exposure on anthropometric measures at birth or small for gestational age (SGA) infants in a large, nationwide Japanese cohort remains to be clarified. OBJECTIVES: To analyze the association between maternal blood Cd levels at different sampling times and sex-dependent infant birth size, weight, body length, chest, and head circumferences, in addition to SGA. METHODS: Data of 17,584 pregnant women in the Japan Environment and Children's Study were analyzed for anthropometric measurements. For SGA determination, 13,969 cases of vaginal delivery were analyzed after excluding infants born by cesarean section. Maternal blood Cd levels were categorized into quartiles (Q1-Q4), and the Q1 was used as a reference. Multiple linear regression analysis was performed for anthropometric measurements, and multiple logistic regression analysis was used to investigate the association of maternal blood Cd levels with the risk of SGA. RESULTS: Birth weight tended to decrease according to the increase in quartiles of blood Cd levels (15.63 g decrease [95% confidence level (CI): -33.26, 2.01] for Q4). The overall analysis revealed no decreases in body length and head and chest circumference, but subgroup analysis revealed that chest circumference tended to decrease according to the increase in quartiles in the female sex/third-trimester stratification (0.16 cm decrease [95% CI: -0.32, 0.00] for Q4). SGA risk was also higher and paralleled the increase in blood Cd levels associated with the female sex/third-trimester group (Odds Ratio 1.90 [95% CI: 1.23, 2.94] for Q4). CONCLUSION: Our results provide further evidence of sex-specific health risks associated with Cd exposure in early life in a large Japanese pregnancy cohort.

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  • Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study

    Ishibashi, Yoshiki, Nishitani, Rie, Shimura, Akiyoshi, Takeuchi, Ayano, Touko, Mamoru, Kato, Takashi, Chiba, Sahoko, Ashidate, Keiko, Ishiwata, Nobuo, Ichijo, Tomoyasu, Sasabe, Masataka

    PLOS ONE   15 ( 9 )   2020.9

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  • Modeling and estimation of harmful substances by statistical analysis of delayed luminescence decay curves obtained from green algae Raphidocelis subcapitata

    Ikushima, Yuko, Takeuchi, Ayano, Katsumata, Masakazu, Sato, Yukiko, Hakamata, Tomoyuki

    JOURNAL OF LUMINESCENCE   223   2020.7

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  • Predictive factors for liver volume and function recovery after resection using three-dimensional analysis

    Nakano, Yutaka, Itano, Osamu, Shinoda, Masahiro, Kitago, Minoru, Yagi, Hiroshi, Abe, Yuta, Takeuchi, Ayano, Takemura, Yusuke, Kitagawa, Yuko

    HPB   22 ( 6 )   845 - 854   2020.6

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    DOI: 10.1016/j.hpb.2019.10.002

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  • Nitrate Promotes Germination Under Inhibition by NaCl or High Concentration of Glucose

    Ikeya, Shun, Aoyanagi, Takuya, Ishizuka, Imari, Takeuchi, Ayano, Kozaki, Akiko

    PLANTS-BASEL   9 ( 6 )   2020.6

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  • Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan. Reviewed International journal

    Takahiro Nakamura, Yuji Nishiwaki, Kunio Hashimoto, Ayano Takeuchi, Tasuku Kitajima, Kazuhiro Komori, Kasumi Tashiro, Hideki Hasunuma, Kayo Ueda, Atsushi Shimizu, Hiroshi Odajima, Hiroyuki Moriuchi, Masahiro Hashizume

    Environmental health and preventive medicine   25 ( 1 )   8 - 8   2020.3

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    BACKGROUND: Studies on the adverse effects of Asian dust (AD) on respiratory function in children are scarce. The objective of this study was to examine the association between AD and respiratory function by measuring peak expiratory flow rates (PEFRs) in asthmatic children. METHODS: The study was carried out from March to May from 2014 through 2016. One hundred ten children with bronchial asthma were recruited from four hospitals in the Goto Islands and south Nagasaki area in Nagasaki prefecture. The parents were asked to record their children's PEFRs every morning/evening and clinical symptoms in an asthma diary. AD was assessed from light detection and ranging data, and a linear mixed-effects model was used to estimate the effects of AD on daily PEFR. Time-stratified case-crossover analyses were performed to examine the association between AD and asthma attacks defined by reduction levels in PEFR. RESULTS: AD was detected on 11 days in the Goto Islands, and on 23 days in the south Nagasaki area. After adjusting for age, sex, temperature, and daily oxidants, we found a consistent association between AD and a 1.1% to 1.7% decrease in PEFR in the mornings and a 0.7% to 1.3% decrease in the evenings at a lag of 0 to 5 days. AD was not associated with the number of asthma attacks, respiratory symptoms, or other symptoms at any lag days examined. CONCLUSIONS: Exposure to AD was associated with reduced PEFR, although the effects were not large enough to induce clinically apparent symptoms, in clinically well-controlled asthmatic children.

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  • Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery Reviewed

    Masatsugu Ishii, Osamu Itano, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Ayano Takeuchi, Hanako Tsujikawa, Tokiya Abe, Yuko Kitagawa

    World Journal of Gastroenterology   26 ( 8 )   725 - 739   2020.2

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    ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. BACKGROUND Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic reserve. When determining eligibility for hepatectomy, the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative therapy. AIM To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function recovery. METHODS This study was a retrospective cohort study. We retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December 2016. Early post-hepatectomy liver failure (PHLF) was defined using the International Study Group of Liver Surgery’s definition of PHLF. Long-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of < 2 mg/dL and > 2.8 g/dL, respectively, and the time taken for Child-Pugh score to return to Child-Pugh class A. RESULTS Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function. Further analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S ≤ 6 ng/mL than in those with type IV collagen 7S > 6 ng/mL. In additional analyses, similar results were observed in patients without chronic viral hepatitis associated with fibrosis. CONCLUSION Preoperative type IV collagen 7S is a preoperative predictor of PHLF and long-term postoperative liver function recovery. It can also be used in patients without chronic hepatitis virus.

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  • Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus Reviewed

    Fukushima, K, Harada, S, Takeuchi, A, Kurihara, A, Iida, M, Fukai, K, Kuwabara, K, Kato, S, Matsumoto, M, Hirata, A, Akiyama, M, Tomita, M, Hirayama, A, Sato, A, Suzuki, C, Sugimoto, M, Soga, T, Sugiyama, D, Takebayashi, T

    J. Clini. Lipidol   13 ( 6 )   932 - 939   2019.11

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    © 2019 National Lipid Association Background: Branched-chain amino acids (BCAAs) play a key role in energy homeostasis. Objective: We aimed to investigate the association between plasma BCAA levels and dyslipidemia in the Japanese population without diabetes mellitus. Methods: This cross-sectional study included 4952 participants without diabetes mellitus, enrolled in the Tsuruoka Metabolomic Cohort Study. Plasma BCAA levels were measured by capillary electrophoresis–mass spectrometry. Correlations between lipid and BCAA profiles were evaluated by sex-stratified multiple linear regression analyses, after adjusting for confounders. Logistic regression was used to identify associations between BCAAs and metabolic dyslipidemia (MD) defined as triglyceride levels ≥150 mg/dL, high-density lipoprotein cholesterol levels ≤40 mg/dL for men and ≤50 mg/dL for women, or low-density lipoprotein cholesterol (LDL-C) levels ≥140 mg/dL. Results: In both sexes, the levels of individual BCAAs and the total BCAA levels correlated positively with triglyceride levels and negatively with high-density lipoprotein cholesterol levels. Valine, leucine, and total BCAA levels were weakly and positi

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  • Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS)

    Shoji F. Nakayama, Miyuki Iwai-Shimada, Tomoko Oguri, Tomohiko Isobe, Ayano Takeuchi, Yayoi Kobayashi, Takehiro Michikawa, Shin Yamazaki, Hiroshi Nitta, Toshihiro Kawamoto, Hirohisa Saito, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Michihiro Kamijima, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Yasuaki Hirooka, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh

    Journal of Exposure Science and Environmental Epidemiology   29 ( 5 )   633 - 647   2019.9

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    © 2019, The Author(s). The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51–0.78) µg dl−1, 3.83 (2.70–5.43) µg l−1, 0.70 (0.52–0.95) µg l−1, 16.1 (13.2–19.6) µg l−1 and 178 (165–192) µg l−1, respectively. Hg and Se correlated positively with each other (Spearman’s ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5–10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.

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  • Occupational exposure limits for cumene, 2,4-dichlorophenoxy acetic acid, silicon carbide whisker, benzyl alcohol, and methylamine, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications

    Atsuko Araki, Kenichi Azuma, Ginji Endo, Yoko Endo, Tetsuhito Fukushima, Kunio Hara, Koji Harada, Hajime Hori, Seichi Horie, Masayoshi Ichiba, Gaku Ichihara, Masayuki Ikeda, Akiyoshi Ito, Yuki Ito, Satoko Iwasawa, Takeyasu Kakumu, Michihiro Kamijima, Kanae Karita, Takahiko Katoh, Toshio Kawai, Toshihiro Kawamoto, Shinji Kumagai, Yukinori Kusaka, Akiko Matsumoto, Muneyuki Miyagawa, Hiroyuki Miyauchi, Yasuo Morimoto, Kasuke Nagano, Hisao Naito, Tamie Nakajima, Makiko Nakano, Tetsuo Nomiyama, Hirokazu Okuda, Masayuki Okuda, Kazuyuki Omae, Haruhiko Sakurai, Kazuhiro Sato, Tomotaka Sobue, Yasushi Suwazono, Toru Takebayashi, Tatsuya Takeshita, Akito Takeuchi, Ayano Takeuchi, Masatoshi Tanaka, Shigeru Tanaka, Teruomi Tsukahara, Masashi Tsunoda, Susumu Ueno, Jun Ueyama, Yumi Umeda, Kenya Yamamoto, Yuko Yamano, Takenori Yamauchi, Eiji Yano

    JOURNAL OF OCCUPATIONAL HEALTH   61 ( 4 )   328 - 330   2019.7

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    DOI: 10.1002/1348-9585.12073

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  • Association between blood manganese level during pregnancy and birth size: The Japan environment and children's study (JECS). International journal

    Midori Yamamoto, Kenichi Sakurai, Akifumi Eguchi, Shin Yamazaki, Shoji F Nakayama, Tomohiko Isobe, Ayano Takeuchi, Tosiya Sato, Akira Hata, Chisato Mori, Hiroshi Nitta

    Environmental research   172   117 - 126   2019.5

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    BACKGROUND: Manganese (Mn) is both an essential element and a potential toxicant. Although a few studies have suggested a nonlinear relationship between the maternal whole blood Mn level at delivery and infant birth weight, little is known about the effects of Mn levels during pregnancy on fetal growth, particularly with regard to sex-specific differences. METHODS: In this nationwide birth cohort study, we examined the association of maternal blood Mn level during pregnancy with infant birth weight, length, and head circumference in 16,473 mother-infant pairs. Pregnant women living in 15 regions across Japan were recruited between January 2011 and March 2014. The analysis of birth size (8,484 males and 7,989 females) was conducted using a nonlinear spline, followed by the use of quadratic regression or linear regression models. The analysis of small-for-gestational-age (SGA) (6,962 males and 6,528 females born vaginally) was conducted using multivariate logistic regression. Additionally, subgroup analysis was conducted according to the timing of blood sampling. RESULTS: The median maternal blood Mn level during pregnancy (i.e., 2nd and 3rd trimesters) was 16.2 µg/L (range, 4.3-44.5 µg/L). A positive linear association between the log blood Mn level and head circumference was observed in both male and female infants. However, a nonlinear relationship between the log blood Mn level and birth weight was observed only in male infants, such that the birth weight increased up to a blood Mn level of 18.6 µg/L. In the subgroup analysis stratified by the timing of maternal blood sampling, this nonlinear relationship was obvious only when sampling was performed in the 3rd trimester. Male infants in the lowest blood Mn level quartile (≤ 13.2 µg/L) faced an increased risk of SGA (odds ratio [95% confidence interval] = 1.35 [1.04-1.74]), as did those in the highest blood Mn level quartile (≥ 21.0 µg/L) when sampling was performed during the 3rd trimester (odds ratio [95% confidence interval] = 1.62 [1.10 to 2.39]), compared to those in the third blood Mn level quartile (the category including 18.6 µg/L). No association of blood Mn level with birth weight was observed among female infants, and blood Mn level was not associated with birth length in either male or female infants. CONCLUSION: A low blood Mn level during pregnancy or a high blood Mn level during the 3rd trimester was associated with a lower birth weight and increased risk of SGA in male infants, but not in female infants. A low blood Mn level was found to correlate slightly with a small head circumference among infants of both sexes.

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  • Clinical outcomes and prognostic factors for cavernous hemangiomas of the spinal cord: a retrospective cohort study Reviewed International journal

    Narihito Nagoshi, Osahiko Tsuji, Daisuke Nakashima, Ayano Takeuchi, Kaori Kameyama, Eijiro Okada, Nobuyuki Fujita, Mitsuru Yagi, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

    Journal of neurosurgery. Spine   31 ( 2 )   271 - 278   2019.4

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    OBJECTIVE: Intramedullary cavernous hemangioma (CH) is a rare vascular lesion that is mainly characterized by the sudden onset of hemorrhage in young, asymptomatic patients, who then experience serious neurological deterioration. Despite the severity of this condition, the therapeutic approach and timing of intervention for CH remain matters of debate. The aim of this study was to evaluate the clinical characteristics of CH patients before and after surgery and to identify prognostic indicators that affect neurological function in these patients. METHODS: This single-center retrospective study included 66 patients who were treated for intramedullary CH. Among them, 57 underwent surgery and 9 patients received conservative treatment. The authors collected demographic, symptomology, imaging, neurological, and surgical data. Univariate and multivariate logistic regression analyses were performed to identify the prognostic indicators for neurological function. RESULTS: When comparing patients with stable and unstable gait prior to surgery, patients with unstable gait had a higher frequency of hemorrhagic episodes (52.4% vs 19.4%, p = 0.010), as assessed by the modified McCormick Scale. The lesion was significantly smaller in patients who underwent conservative treatment compared with surgery (2.5 ± 1.5 mm vs 5.9 ± 4.1 mm, respectively; p = 0.024). Overall, the patients experienced significant neurological recovery after surgery, but a worse preoperative neurological status was identified as an indicator affecting surgical outcomes by multivariate analysis (OR 10.77, 95% CI 2.88–40.36, p < 0.001). In addition, a larger lesion size was significantly associated with poor functional recovery in patients who had an unstable gait prior to surgery (8.6 ± 4.5 mm vs 3.5 ± 1.6 mm, p = 0.011). CONCLUSIONS: Once a hemorrhage occurs, surgical intervention should be considered to avoid recurrence of the bleeding and further neurological injury. In contrast, if the patients with larger lesion presented with worse preoperative functional status, surgical intervention could have a risk for aggravating the functional deficiencies by damaging the thinning cord parenchyma. Conservative treatment may be selected if the lesion is small, but regular neurological examination by MRI is needed for assessment of a change in lesion size and for detection of functional deterioration. ABBREVIATIONS: AIS = ASIA Impairment Scale; ASIA = American Spinal Injury Association; CH = cavernous hemangioma; EBL = estimated blood loss; JOA = Japanese Orthopaedic Association; mMS = modified McCormick Scale.

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  • Randomized Phase II Trial Comparing Site-Specific Treatment Based on Gene Expression Profiling With Carboplatin and Paclitaxel for Patients With Cancer of Unknown Primary Site. Reviewed

    Hayashi H, Kurata T, Takiguchi Y, Arai M, Takeda K, Akiyoshi K, Matsumoto K, Onoe T, Mukai H, Matsubara N, Minami H, Toyoda M, Onozawa Y, Ono A, Fujita Y, Sakai K, Koh Y, Takeuchi A, Ohashi Y, Nishio K, Nakagawa K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology   37 ( 7 )   570 - 579   2019.3

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    <sec><title>PURPOSE</title> Although gene expression profiling is a promising diagnostic technique to determine the tissue of origin for patients with cancer of unknown primary site (CUP), no clinical trial has evaluated yet site-specific therapy directed by this approach compared with empirical chemotherapy. We therefore performed a randomized study to assess whether such site-specific therapy improves outcome compared with empirical chemotherapy in previously untreated patients with CUP.

    </sec><sec><title>PATIENTS AND METHODS</title> Comprehensive gene expression profiling was performed by microarray analysis, and an established algorithm was applied to predict tumor origin. Patients with CUP were randomly assigned (1:1) to receive standard site-specific therapy or empirical paclitaxel and carboplatin (PC). The primary end point was 1-year survival rate.

    </sec><sec><title>RESULTS</title> One hundred thirty patients were randomly assigned and had sufficient biopsy tissue for molecular analysis. Efficacy analysis was performed for 50 and 51 patients in the site-specific therapy and empirical PC arms, respectively. Cancer types most commonly predicted were pancreatic (21%), gastric (21%), and lymphoma (20%). The 1-year survival rate was 44.0% and 54.9% for site-specific treatment and empirical PC ( P = .264), respectively. Median overall and progression-free survival were 9.8 and 5.1 months, respectively, for site-specific treatment versus 12.5 and 4.8 months for empirical PC ( P = .896 and .550, respectively). Median overall survival (16.7 v 10.6 months; P = .116) and progression-free survival (5.5 v 3.9 months; P = .018) were better for predicted more-responsive than less-responsive tumor types.

    </sec><sec><title>CONCLUSION</title> Site-specific treatment that was based on microarray profiling did not result in a significant improvement in 1-year survival compared with empirical PC, although prediction of the original site seemed to be of prognostic value.

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  • Body Temperature, Heart Rate, and Short-Term Outcome of Cooled Infants. International journal

    Kennosuke Tsuda, Sachiko Iwata, Takeo Mukai, Jun Shibasaki, Akihito Takeuchi, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Toshiki Takenouchi, Satoshi Osaga, Takuya Tokuhisa, Sachio Takashima, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata

    Therapeutic hypothermia and temperature management   9 ( 1 )   76 - 85   2019.3

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    Therapeutic hypothermia following neonatal encephalopathy is neuroprotective. However, approximately one in two cooled infants still die or develop permanent neurological impairments. Further understanding of variables associated with the effectiveness of cooling is important to improve the therapeutic regimen. To identify clinical factors associated with short-term outcomes of cooled infants, clinical data of 509 cooled infants registered to the Baby Cooling Registry of Japan between 2012 and 2014 were evaluated. Independent variables of death during the initial hospitalization and survival discharge from the cooling hospital at ≤28 days of life were assessed. Death was associated with higher Thompson scores at admission (p < 0.001); higher heart rates after 3-72 hours of cooling (p < 0.001); and higher body temperature after 24 hours of cooling (p = 0.002). Survival discharge was associated with higher 10 minutes Apgar scores (p < 0.001); higher blood pH and base excess (both p < 0.001); lower Thompson scores (at admission and after 24 hours of cooling; both p < 0.001); lower heart rates at initiating cooling (p = 0.003) and after 24 hours of cooling (p < 0.001) and lower average values after 3-72 hours of cooling (p < 0.001); higher body temperature at admission (p < 0.001); and lower body temperature after 24 hours and lower mean values after 3-72 hours of cooling (both p < 0.001). Survival discharge was best explained by higher blood pH (p < 0.05), higher body temperature at admission (p < 0.01), and lower body temperature and heart rate after 24 hours of cooling (p < 0.01 and <0.001, respectively). Lower heart rate, higher body temperature at admission, and lower body temperature during cooling were associated with favorable short-term outcomes.

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  • Does Posterior Cervical Decompression Conducted by Junior Surgeons Affect Clinical Outcomes in the Treatment of Cervical Spondylotic Myelopathy? Results From a Multicenter Study

    Nagoshi N, Iwanami A, Isogai N, Ishikawa M, Nojiri K, Tsuji T, Daimon K, Takeuchi A, Tsuji O, Okada E, Fujita N, Yagi M, Watanabe K, Nakamura M, Matsumoto M, Ishii K, Yamane J

    Global Spine Journal   9 ( 1 )   25 - 31   2019.2

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    © The Author(s) 2018. Study Design: Retrospective multicenter study. Objectives: To evaluate the outcomes of posterior cervical decompression for cervical spondylotic myelopathy (CSM) when performed by board-certified spine (BCS) or non-BCS (NBCS) surgeons. Methods: We reviewed outcomes for 675 patients who underwent surgery for CSM, were followed at least 1 year after surgery, and were assessed preoperatively and at final follow-up by Japanese Orthopaedic Association (JOA) scores and by the visual analog scale (VAS) for the neck. Cervical alignment was assessed on radiographs by C2-C7 angles, and range of motion (ROM) by extension minus flexion C2-C7 angles. We compared outcomes for BCS surgeons, who must meet several requirements, including experience in more than 300 spinal surgeries, and for NBCS surgeons. Results: BCS surgeons performed 432 of 675 laminoplasties. NBCS surgeons were primary in 243 surgeries, of which 187 were directly supervised by a BCS surgeon. BCS surgeons required significantly less time in surgery (98.0 ± 39.5 vs 108.1 ± 49.7 min; P <.01). BCS and NBCS surgeons had comparable perioperative complications rates, and preoperative-to-postoperative changes in JOA scores (2.9 ± 2.1 vs 3.1 ± 2.3; P =.40) and VAS (−1.5 ± 2.9 vs −1.4 ± 2.5; P =.96). Lordotic cervical alignment and ROM were maintained after operations by both groups. Conclusions: Surgical outcomes such as functional recovery, complication rates, and cervical dynamics were comparable between the BCS and NBCS groups. Thus, posterior cervical decompression for CSM is safe and effective when performed by junior surgeons who have been trained and supervised by experienced spine surgeons.

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  • Efficient hydrogen production using photosystem I enhanced by artificial light harvesting dye

    Nagakawa, Haruki, Takeuchi, Ayano, Takekuma, Yuya, Noji, Tomoyasu, Kawakami, Keisuke, Kamiya, Nobuo, Nango, Mamoru, Furukawa, Rei, Nagata, Morio

    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES   18 ( 2 )   309 - 313   2019.2

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    In this study, we improved the hydrogen production efficiency by combining photosystem I with an artificial light harvesting dye, Lumogen Red. In the reaction system, Lumogen Red allows light absorption and energy transfer to photosystem I by Förster resonance energy transfer; therefore, the Pt nanoparticles act as active sites for hydrogen generation.

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  • Randomized Phase II Trial Comparing Site-Specific Treatment Based on Gene Expression Profiling With Carboplatin and Paclitaxel for Patients With Cancer of Unknown Primary Site

    Hayashi, H, Kurata, T, Takiguchi, Y, Arai, M, Takeda, K, Akiyoshi, K, Matsumoto, K, Onoe, T, Mukai, H, Matsubara, N, Minami, H, Toyoda, M, Onozawa, Y, Ono, A, Fujita, Y, Sakai, K, Koh, Y, Takeuchi, A, Ohashi, Y, Nishio, K, Nakagawa, K

    J Clin Oncol   37 ( 7 )   JCO1800771 - 579   2019.1

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    PURPOSE: Although gene expression profiling is a promising diagnostic technique to determine the tissue of origin for patients with cancer of unknown primary site (CUP), no clinical trial has evaluated yet site-specific therapy directed by this approach compared with empirical chemotherapy. We therefore performed a randomized study to assess whether such site-specific therapy improves outcome compared with empirical chemotherapy in previously untreated patients with CUP. PATIENTS AND METHODS: Comprehensive gene expression profiling was performed by microarray analysis, and an established algorithm was applied to predict tumor origin. Patients with CUP were randomly assigned (1:1) to receive standard site-specific therapy or empirical paclitaxel and carboplatin (PC). The primary end point was 1-year survival rate. RESULTS: One hundred thirty patients were randomly assigned and had sufficient biopsy tissue for molecular analysis. Efficacy analysis was performed for 50 and 51 patients in the site-specific therapy and empirical PC arms, respectively. Cancer types most commonly predicted were pancreatic (21%), gastric (21%), and lymphoma (20%). The 1-year survival rate was 44.0% and 54.9% for site-specific treatment and empirical PC ( P = .264), respectively. Median overall and progression-free survival were 9.8 and 5.1 months, respectively, for site-specific treatment versus 12.5 and 4.8 months for empirical PC ( P = .896 and .550, respectively). Median overall survival (16.7 v 10.6 months; P = .116) and progression-free survival (5.5 v 3.9 months; P = .018) were better for predicted more-responsive than less-responsive tumor types. CONCLUSION: Site-specific treatment that was based on microarray profiling did not result in a significant improvement in 1-year survival compared with empirical PC, although prediction of the original site seemed to be of prognostic value.

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  • High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma: Immunohistochemical analysis and the expression of p53 and phosphorylated AKT Reviewed

    Fusumae T, Tanese K, Takeuchi A, Takasugi A, Kawakita R, Shiraishi J, Yoshida T

    Journal of Dermatology   46 ( 1 )   57 - 60   2019.1

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    © 2018 Japanese Dermatological Association Trichoblastoma (TB) is a benign cutaneous adnexal neoplasm. The lesion typically presents as a slow-growing, solitary, well-circumscribed nodule measuring up to 3 cm in diameter. On rare occasions, TB causes malignant transformation into an aggressive form described as high-grade trichoblastic carcinoma. Four such cases have been reported to date; all were described as high-grade trichoblastic carcinomas. Here, we describe the case of a 72-year-old Japanese male patient with a rapidly enlarging subcutaneous tumor on his lower back, which was diagnosed as high-grade trichoblastic carcinoma. Histopathologically, the tumor featured both benign and malignant components, and a transition zone between these states was clearly evident. In the immunohistochemical analysis, a malignant component was positive for p53 and showed stronger staining of phospho-RAC-α serine/threonine-protein kinase (AKT) Ser473 in comparison with a benign component. These results suggest that loss of p53 function and activation of phosphatidylinositol 3-kinase–AKT signaling pathways played important pathogenic roles in malignant transformation of the present case.

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  • High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma: Immunohistochemical analysis and the expression of p53 and phosphorylated AKT

    Fusumae, T, Tanese, K, Takeuchi, A, Takasugi, A, Kawakita, R, Shiraishi, J, Yoshida, T

    J Dermatol   46 ( 1 )   57 - 60   2019.1

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    Trichoblastoma (TB) is a benign cutaneous adnexal neoplasm. The lesion typically presents as a slow-growing, solitary, well-circumscribed nodule measuring up to 3 cm in diameter. On rare occasions, TB causes malignant transformation into an aggressive form described as high-grade trichoblastic carcinoma. Four such cases have been reported to date; all were described as high-grade trichoblastic carcinomas. Here, we describe the case of a 72-year-old Japanese male patient with a rapidly enlarging subcutaneous tumor on his lower back, which was diagnosed as high-grade trichoblastic carcinoma. Histopathologically, the tumor featured both benign and malignant components, and a transition zone between these states was clearly evident. In the immunohistochemical analysis, a malignant component was positive for p53 and showed stronger staining of phospho-RAC-alpha serine/threonine-protein kinase (AKT) Ser473 in comparison with a benign component. These results suggest that loss of p53 function and activation of phosphatidylinositol 3-kinase-AKT signaling pathways played important pathogenic roles in malignant transformation of the present case.

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  • Breakfast Dietary Patterns, Energy and Protein Among Philippines Families with Children

    Nakamura, Taro, Kawamata, Yuka, Sugita, Mayu, Nozawa, Yoshizu, Takeuchi, Ayano

    ANNALS OF NUTRITION AND METABOLISM   75   110 - 111   2019

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  • Health Effects of Asian Dust Events: A Literature Review Update of Epidemiological Evidence Reviewed

    HASUNUMA Hideki, WATANABE Masanari, HASHIZUME Masahiro, ICHINOSE Takamichi, UEDA Kayo, ODAJIMA Hiroshi, KANATANI Kumiko, SHIMIZU Atsushi, TAKAMI Akinori, TAKEUCHI Ayano, NISHIWAKI Yuji

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   74 ( 0 )   n/a   2019

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    <p>Asian dust is a phenomenon involving the long-range transport of atmospheric pollutants originating from the desert areas of China and Mongolia. In recent years, the health effects of Asian dust have raised public concerns. Numerous studies on the health effects of Asian dust have been published since the last review in 2010. Thus, a literature review was conducted to shed light on the latest epidemiologic findings. PubMed and Science Direct databases were used for the review of epidemiologic studies published between June 2009 and April 2018. We identified 53 epidemiologic studies. Mortality, ambulance transportation, hospitalization/medical examination, changes in symptomatic, functional, and examination findings, as well as birth outcomes have been reported as outcomes. When the outcomes were categorized by disease, the effects of Asian dust on respiratory, cardiovascular, and allergic diseases raised concerns. The common evidences of causation between Asian dust and these diseases were the consistency of findings and temporal sequence of association. As results of research on dose-response relationships have become available, and the possibility that the health effects of Asian dust may vary depending on its chemical composition has been pointed out, further research using the exposure level indicators of Asian dust or its chemical composition should be conducted. Furthermore, with focus on the crucial issue of reducing exposure, research related to prevention and raising awareness should be further promoted.</p>

    DOI: 10.1265/jjh.19010

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  • Prevalence of Metabolic Syndrome and Lifestyle Characteristics by Business Type among Japanese Workers in Small- and Medium-sized Enterprises

    Hozawa, H, Takeuchi, A, Oguma, Y

    Keio J Med   2018.12

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    This cross-sectional study investigated the associations of business type with the prevalence of metabolic syndrome (MetS) and lifestyle characteristics among workers in small- and medium-sized enterprises. In total, data from 167,736 workers (114,746 men and 52,990 women) who participated in health checkups in 2013 were analyzed using multilevel logistic regression models. The odds ratios (ORs) of having MetS, defined based on the criteria of the joint interim statement, were significantly higher in employees of transportation businesses (reference OR =1) than in other business types among men (OR: 0.67-0.85) and similar result was observed among women (OR: 0.70-0.88). The prevalence of a smoking habit was significantly higher in transportation workers than in employees of other businesses for both men and women. Furthermore, male transportation workers were more likely to skip breakfast, engage in <1 h/day of walking, walk at a slower speed, and eat dinner just before going to bed. Female transportation workers were more likely to have gained 10 kg since the age of 20 years. In conclusion, the prevalence of MetS was higher in transportation workers than in workers from other busi

    DOI: 10.2302/kjm.2018-0007-OA

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  • Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population

    Mariko Sasaki, Sei Harada, Yumiko Kawasaki, Miki Watanabe, Hidemi Ito, Hideo Tanaka, Ayano Takeuchi, Kazuo Tsubota, Toru Takebayashi, Yuji Nishiwaki, Ryo Kawasaki

    Scientific Reports   8 ( 1 )   785   2018.12

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    The Tsuruoka Metabolomics Cohort Study included subjects aged 35-74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17-2.23 and 0.64-0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01-1.44 and 1.03-1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10-5.04) than men (OR: 1.65, 95% CI: 1.02-2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex.

    DOI: 10.1038/s41598-017-18487-4

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  • Imaging Comparison Between Chinese and Japanese Patients With Cervical Ossification of the Posterior Longitudinal Ligament

    Xiao, B, Nagoshi, N, Takeuchi, A, Mao, J, Liu, B, Tian, W, Tsuji, O, Okada, E, Fujita, N, Yagi, M, Nakamura, M, Matsumoto, M, Ishii, K, Watanabe, K

    Spine (Phila Pa 1976)   43 ( 23 )   E1376 - E1383   2018.12

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    STUDY DESIGN: A retrospective study. OBJECTIVE: To identify the radiographic differences between Chinese and Japanese patients with cervical ossification of the posterior longitudinal ligament (OPLL) using computed tomography (CT) and magnetic resonance imaging (MRI), and to compare the characteristics of OPLL between the two nationalities. SUMMARY OF BACKGROUND DATA: OPLL has a high prevalence in East Asia. However, the differences between Chinese and Japanese OPLL patients are poorly known. METHODS: This was a retrospective study of Chinese (n = 300) and Japanese (n = 102) consecutive patients who received a diagnosis of cervical OPLL between January 2010 and December 2014. All patients underwent CT and MRI. The type and distribution of OPLL were determined. Spinal compression was assessed by MRI. OPLL type, distribution, comorbidity, and compression of the spinal cord were examined. The ossification index (OP-index) was used to evaluate the OPLL. Factors contributing to the OP-index were examined by multivariate analysis. RESULTS: The Chinese patients were younger than the Japanese patients (P < 0.0001), and there were more women among the Chinese patients (P = 0.0002). The OP-index was higher among the Japanese patients (median, 5 vs. 4, P = 0.003). Among men, OPLL lesions were more frequent in the under 55-year-old Japanese at C7 (P = 0.04), in the 55 to 64-year-old Japanese at C4, C5, and C6 (all P < 0.05), and in the over 64-year-old Japanese at C3/4 (P = 0.01), compared with their Chinese counterparts. Among women, OPLL lesions were more frequent in the 55 to 64-year-old Japanese at C6 (P = 0.04). The multivariate analysis showed that only age was independently associated with the OP-index (odds ratio [OR] = 1.023, 95% confidence interval [CI]: 1.002-1.045, P = 0.034). CONCLUSION: Japanese patients had a higher frequency of OPLL lesions at C5, C6, and C7. Age was independently associated with OPLL. LEVEL OF EVIDENCE: 3.

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  • A combination of routine laboratory findings and vital signs can predict survival of advanced cancer patients without physician evaluation: a fractional polynomial model. International journal

    Jun Hamano, Ayano Takeuchi, Takuhiro Yamaguchi, Mika Baba, Kengo Imai, Masayuki Ikenaga, Yoshihisa Matsumoto, Ryuichi Sekine, Takashi Yamaguchi, Takeshi Hirohashi, Tsukasa Tajima, Ryohei Tatara, Hiroaki Watanabe, Hiroyuki Otani, Hiroka Nagaoka, Masanori Mori, Yo Tei, Shuji Hiramoto, Tatsuya Morita

    European journal of cancer (Oxford, England : 1990)   105   50 - 60   2018.12

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    INTRODUCTION: There have been no reports about predicting survival of patients with advanced cancer constructed entirely with objective variables. We aimed to develop a prognostic model based on laboratory findings and vital signs using a fractional polynomial (FP) model. METHODS: A multicentre prospective cohort study was conducted at 58 specialist palliative care services in Japan from September 2012 to April 2014. Eligible patients were older than 20 years and had advanced cancer. We developed models for predicting 7-day, 14-day, 30-day, 56-day and 90-day survival by using the FP modelling method. RESULTS: Data from 1039 patients were analysed to develop each prognostic model (Objective Prognostic Index for advanced cancer [OPI-AC]). All models included the heart rate, urea and albumin, while some models included the respiratory rate, creatinine, C-reactive protein, lymphocyte count, neutrophil count, total bilirubin, lactate dehydrogenase and platelet/lymphocyte ratio. The area under the curve was 0.77, 0.81, 0.90, 0.90 and 0.92 for the 7-day, 14-day, 30-day, 56-day and 90-day model, respectively. The accuracy of the OPI-AC predicting 30-day, 56-day and 90-day survival was significantly higher than that of the Palliative Prognostic Score or the Prognosis in Palliative Care Study model, which are based on a combination of symptoms and physician estimation. CONCLUSION: We developed highly accurate prognostic indexes for predicting the survival of patients with advanced cancer from objective variables alone, which may be useful for end-of-life management. The FP modelling method could be promising for developing other prognostic models in future research.

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  • Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components

    Fujita Y, Kitago M, Abe T, Itano O, Shinoda M, Abe Y, Yagi H, Hibi T, Ishii M, Nakano Y, Okuma K, Hashimoto M, Takeuchi A, Masugi Y, Jinzaki M, Sakamoto M, Kitagawa Y

    Pancreas   47 ( 10 )   1277 - 1282   2018.11

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    © 2018 Wolters Kluwer Health, Inc. All rights reserved. Objectives The aim of this study was to determine whether computer-assisted digital analysis and acoustic radiation force impulse (ARFI) imaging were useful for assessing pancreatic fibrosis, and if ARFI imaging predicted postoperative pancreatic fistula (POPF). Methods Seventy-eight patients scheduled to undergo pancreatic resection were enrolled. Shear wave velocity (SWV) at the pancreatic neck was measured preoperatively using ARFI imaging. Pancreatic tissue components on a whole slide image were quantified using an automatic image processing software. The relationship between SWV, fibrotic tissue content, and POPF incidence and clinical severity was analyzed. Results The median collagen fiber, fatty tissue, and acinar cell contents were 11.6%, 8.5%, and 61.3%, respectively. Unlike fatty tissue, collagen fiber content and acinar cells were correlated with SWV (ρ = 0.440, P &lt; 0.001 and ρ =-0.428, P &lt; 0.001, respectively). Although collagen fiber content and SWV were associated with the overall incidence of POPF (P = 0.004 and 0.001, respectively), collagen fiber content and SWV had no statistical correlation with clinical

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  • Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components

    Fujita Y, Kitago M, Abe T, Itano O, Shinoda M, Abe Y, Yagi H, Hibi T, Ishii M, Nakano Y, Okuma K, Hashimoto M, Takeuchi A, Masugi Y, Jinzaki M, Sakamoto M, Kitagawa Y

    Pancreas   47 ( 10 )   1277 - 1282   2018.11

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    © 2018 Wolters Kluwer Health, Inc. All rights reserved. Objectives The aim of this study was to determine whether computer-assisted digital analysis and acoustic radiation force impulse (ARFI) imaging were useful for assessing pancreatic fibrosis, and if ARFI imaging predicted postoperative pancreatic fistula (POPF). Methods Seventy-eight patients scheduled to undergo pancreatic resection were enrolled. Shear wave velocity (SWV) at the pancreatic neck was measured preoperatively using ARFI imaging. Pancreatic tissue components on a whole slide image were quantified using an automatic image processing software. The relationship between SWV, fibrotic tissue content, and POPF incidence and clinical severity was analyzed. Results The median collagen fiber, fatty tissue, and acinar cell contents were 11.6%, 8.5%, and 61.3%, respectively. Unlike fatty tissue, collagen fiber content and acinar cells were correlated with SWV (ρ = 0.440, P &lt; 0.001 and ρ =-0.428, P &lt; 0.001, respectively). Although collagen fiber content and SWV were associated with the overall incidence of POPF (P = 0.004 and 0.001, respectively), collagen fiber content and SWV had no statistical correlation with cl

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  • A combination of routine laboratory findings and vital signs can predict survival of advanced cancer patients without physician evaluation: a fractional polynomial model. Reviewed

    Hamano J, Takeuchi A, Yamaguchi T, Baba M, Imai K, Ikenaga M, Matsumoto Y, Sekine R, Yamaguchi T, Hirohashi T, Tajima T, Tatara R, Watanabe H, Otani H, Nagaoka H, Mori M, Tei Y, Hiramoto S, Morita T

    European journal of cancer (Oxford, England : 1990)   105   50 - 60   2018.11

  • Prevalence and Distribution of Diffuse Idiopathic Skeletal Hyperostosis on Whole-spine Computed Tomography in Patients With Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Study. International journal

    Soraya Nishimura, Narihito Nagoshi, Akio Iwanami, Ayano Takeuchi, Takashi Hirai, Toshitaka Yoshii, Kazuhiro Takeuchi, Kanji Mori, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Kanichiro Wada, Masao Koda, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko Abematsu, Hirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masashi Yamazaki, Kota Watanabe, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi

    Clinical spine surgery   31 ( 9 )   E460-E465 - E465   2018.11

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    STUDY DESIGN: This was a retrospective multicenter study. OBJECTIVE: To clarify the progression of diffuse idiopathic skeletal hyperostosis (DISH) using whole-spine computed tomography in patients with cervical ossification of the posterior longitudinal ligament (OPLL). SUMMARY OF BACKGROUND DATA: DISH and cervical OPLL frequently coexist, and can cause ankylosing spinal fractures due to biomechanical changes and fragility of the affected vertebrae. The epidemiology and pathophysiology of DISH occurring with cervical OPLL are unclear. MATERIALS AND METHODS: We used whole-spine computed tomography to determine the prevalence of DISH in 234 patients with a diagnosis of cervical OPLL based on plain cervical radiographs. We established a novel system for grading the progression of DISH based on a cluster analysis of the DISH distribution along the spine. We calculated the correlation coefficient between this grading system and patient age. RESULTS: The prevalence of DISH in patients with cervical OPLL was 48.7%. Patients with DISH were significantly older than those who did not have DISH (67.3 vs. 63.4 y; P=0.005). Cluster analysis classified the DISH distribution into 6 regions, based on the levels affected: C2-C5, C3-T1, C6-T5, T3-10, T8-L2, and T12-S1. DISH was observed most frequently at T3-T10. We defined a system for grading DISH progression based on the number of regions involved, from grade 0 to 6. DISH was distributed at T3-T10 in >60% of the grade 1 patients, whereas most patients with DISH at the cervical or lumbar spine were grade 4 or 5. There was a weak but significant correlation between the DISH grade and patient age. CONCLUSIONS: DISH was present in nearly half of the patients with cervical OPLL. DISH was more common in older patients. DISH developed at the thoracic level and progressed into the cervical and/or lumbar spine with age. LEVEL OF EVIDENCE: Level III.

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  • Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis

    Kasuga, Akiyoshi, Hamamoto, Yasuo, Takeuchi, Ayano, Okano, Naohiro, Togasaki, Kazuhiro, Aoki, Yu, Suzuki, Takeshi, Kawasaki, Kenta, Hirata, Kenro, Sukawa, Yasutaka, Kanai, Takanori, Takaishi, Hiromasa

    INVESTIGATIONAL NEW DRUGS   36 ( 5 )   939 - 948   2018.10

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    © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Background Post-progression survival (PPS) could be a confounding element in interpreting data from clinical trials of second-line chemotherapy in patients with advanced pancreatic cancer (PC) previously treated with gemcitabine (GEM) because a recent meta-analysis of oxaliplatin combination therapy showed statistical heterogeneity for overall survival (OS) but not for progression-free survival (PFS). This study aimed to improve the understanding of the impact of PPS on OS in this setting. Methods Databases were searched to identify randomized controlled trials (RCTs) in the salvage setting. We evaluated relationships between OS and PFS, PPS, and other variables. Results Totally, 17 RCTs with 3253 patients were identified. Median OS was strongly and moderately associated with median PPS and PFS, respectively (r = 0.913; p &lt; 0.001 and 0.780; p &lt; 0.001, respectively). The proportion of patients with good performance status was significantly associated with both PPS and PFS (r = 0.574, p &lt; 0.001 and 0.492, p &lt; 0.001, respectively). The induction rate of subsequent chemotherapy was related to the duration of PPS an

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  • Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children Study (JECS)

    Iwai-Shimada, M, Nakayama, S. F, Isobe, T, Michikawa, T, Yamazaki, S, Nitta, H, Takeuchi, A, Kobayashi, Y, Tamura, K, Suda, E, Ono, M, Yonemoto, J, Kawamoto, T, Japan, Environment, Children's Study, Group

    Environ Health Prev Med   23 ( 1 )   45   2018.9

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    BACKGROUND: The Japan Environment and Children's Study (JECS) is a nation-wide birth cohort study investigating environmental effects on children's health and development. In this study, the exposure characteristics of the JECS participating mothers were summarized using two questionnaires administered during pregnancy. METHODS: Women were recruited during the early period of their pregnancy. We intended to administer the questionnaire during the first trimester (MT1) and the second/third trimester (MT2). The total number of registered pregnancies was 103,099. RESULTS: The response rates of the MT1 and MT2 questionnaires were 96.8% and 95.1%, respectively. The mean gestational ages (SDs) at the time of the MT1 and MT2 questionnaire responses were 16.4 (8.0) and 27.9 (6.5) weeks, respectively. The frequency of participants who reported "lifting something weighing more than 20 kg" during pregnancy was 5.3% for MT1 and 3.9% for MT2. The Cohen kappa scores ranged from 0.07 to 0.54 (median 0.31) about the occupational chemical use between MT1 and MT2 questionnaires. Most of the participants (80%) lived in either wooden detached houses or steel-frame collective housing. More than half of the questionnaire respondents answered that they had "mold growing somewhere in the house". Insect repellents and insecticides were used widely in households: about 60% used "moth repellent for clothes in the closet," whereas 32% applied "spray insecticide indoors" or "mosquito coil or an electric mosquito repellent mat." CONCLUSIONS: We summarized the exposure characteristics of the JECS participants using two maternal questionnaires during pregnancy.

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  • Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children Study (JECS). Reviewed

    Iwai-Shimada M, Nakayama SF, Isobe T, Michikawa T, Yamazaki S, Nitta H, Takeuchi A, Kobayashi Y, Tamura K, Suda E, Ono M, Yonemoto J, Kawamoto T, Japan Environment, Children’s Study Group

    Environmental health and preventive medicine   23 ( 1 )   45   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    Background: The Japan Environment and Children's Study (JECS) is a nation-wide birth cohort study investigating environmental effects on children's health and development. In this study, the exposure characteristics of the JECS participating mothers were summarized using two questionnaires administered during pregnancy.Methods: Women were recruited during the early period of their pregnancy. We intended to administer the questionnaire during the first trimester (MT1) and the second/third trimester (MT2). The total number of registered pregnancies was 103,099.Results: The response rates of the MT1 and MT2 questionnaires were 96.8% and 95.1%, respectively. The mean gestational ages (SDs) at the time of the MT1 and MT2 questionnaire responses were 16.4 (8.0) and 27.9 (6.5) weeks, respectively. The frequency of participants who reported "lifting something weighing more than 20 kg" during pregnancy was 5.3% for MT1 and 3.9% for MT2. The Cohen kappa scores ranged from 0.07 to 0.54 (median 0.31) about the occupational chemical use between MT1 and MT2 questionnaires. Most of the participants (80%) lived in either wooden detached houses or steel-frame collective housing. More than half of the questionnaire respondents answered that they had "mold growing somewhere in the house". Insect repellents and insecticides were used widely in households: about 60% used "moth repellent for clothes in the closet," whereas 32% applied "spray insecticide indoors" or "mosquito coil or an electric mosquito repellent mat."Conclusions: We summarized the exposure characteristics of the JECS participants using two maternal questionnaires during pregnancy.

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  • Prevalence and Distribution of Diffuse Idiopathic Skeletal Hyperostosis on Whole-spine Computed Tomography in Patients With Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Study. Reviewed

    Nishimura S, Nagoshi N, Iwanami A, Takeuchi A, Hirai T, Yoshii T, Takeuchi K, Mori K, Yamada T, Seki S, Tsuji T, Fujiyoshi K, Furukawa M, Wada K, Koda M, Furuya T, Matsuyama Y, Hasegawa T, Takeshita K, Kimura A, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Imagama S, Ando K, Fujibayashi S, Yamazaki M, Watanabe K, Matsumoto M, Nakamura M, Okawa A, Kawaguchi Y, Japanese Organization of the, Study for, Ossification of, Spinal Ligament, JOS

    Clinical spine surgery   2018.8

  • Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity. International journal

    Atsuko Araki, Kenichi Azuma, Ginji Endo, Yoko Endo, Tetsuhito Fukushima, Kunio Hara, Hajime Hori, Seichi Horie, Hyogo Horiguchi, Masayoshi Ichiba, Gaku Ichihara, Masayuki Ikeda, Tatsuya Ishitake, Akiyoshi Ito, Yuki Ito, Satoko Iwasawa, Takeyasu Kakumu, Michihiro Kamijima, Kanae Karita, Takahiko Katoh, Toshio Kawai, Toshihiro Kawamoto, Shinji Kumagai, Yukinori Kusaka, Akiko Matsumoto, Muneyuki Miyagawa, Hiroyuki Miyauchi, Yasuo Morimoto, Kasuke Nagano, Hisao Naito, Tamie Nakajima, Makiko Nakano, Tetsuo Nomiyama, Hirokazu Okuda, Masayuki Okuda, Kazuyuki Omae, Haruhiko Sakurai, Kazuhiro Sato, Tomotaka Sobue, Yasushi Suwazono, Toru Takebayashi, Tatsuya Takeshita, Akito Takeuchi, Ayano Takeuchi, Masatoshi Tanaka, Shigeru Tanaka, Teruomi Tsukahara, Masashi Tsunoda, Susumu Ueno, Jun Ueyama, Yumi Umeda, Kenya Yamamoto, Yuko Yamano, Takenori Yamauchi, Eiji Yano

    Journal of occupational health   60 ( 4 )   333 - 335   2018.7

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    DOI: 10.1539/joh.2018-0137-OP

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  • Imaging Comparison Between Chinese and Japanese Patients With Cervical Ossification of the Posterior Longitudinal Ligament. Reviewed

    Xiao B, Nagoshi N, Takeuchi A, Mao J, Liu B, Tian W, Tsuji O, Okada E, Fujita N, Yagi M, Nakamura M, Matsumoto M, Ishii K, Watanabe K

    Spine   43 ( 23 )   E1376 - E1383   2018.5

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  • Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis

    Akiyoshi Kasuga, Yasuo Hamamoto, Ayano Takeuchi, Naohiro Okano, Kazuhiro Togasaki, Yu Aoki, Takeshi Suzuki, Kenta Kawasaki, Kenro Hirata, Yasutaka Sukawa, Takanori Kanai, Hiromasa Takaishi

    Investigational New Drugs   36 ( 5 )   1 - 10   2018.3

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    Summary: Background Post-progression survival (PPS) could be a confounding element in interpreting data from clinical trials of second-line chemotherapy in patients with advanced pancreatic cancer (PC) previously treated with gemcitabine (GEM) because a recent meta-analysis of oxaliplatin combination therapy showed statistical heterogeneity for overall survival (OS) but not for progression-free survival (PFS). This study aimed to improve the understanding of the impact of PPS on OS in this setting. Methods Databases were searched to identify randomized controlled trials (RCTs) in the salvage setting. We evaluated relationships between OS and PFS, PPS, and other variables. Results Totally, 17 RCTs with 3253 patients were identified. Median OS was strongly and moderately associated with median PPS and PFS, respectively (r = 0.913
    p &lt
    0.001 and 0.780
    p &lt
    0.001, respectively). The proportion of patients with good performance status was significantly associated with both PPS and PFS (r = 0.574, p &lt
    0.001 and 0.492, p &lt
    0.001, respectively). The induction rate of subsequent chemotherapy was related to the duration of PPS and OS (r = 0.640, p &lt
    0.001 and 0.647, p &lt
    0.001, respectively). Median PPS and OS were significantly longer in recent trials than those in older trials (3.55 versus 2.78 months, p &lt
    0.001 and 6.29 versus 5.02 months, p &lt
    0.001). Conclusions Median PPS was strongly correlated with median OS. Given the recently increased opportunity for subsequent chemotherapy and supportive care, PPS may serve as an important element to clarify problems in this setting.

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  • KRAS mutations in cell-free DNA from preoperative and postoperative sera as a pancreatic cancer marker: a retrospective study. International journal

    Yutaka Nakano, Minoru Kitago, Sachiko Matsuda, Yuki Nakamura, Yusuke Fujita, Shunichi Imai, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yoko Fujii-Nishimura, Ayano Takeuchi, Yutaka Endo, Osamu Itano, Yuko Kitagawa

    British journal of cancer   118 ( 5 )   662 - 669   2018.3

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    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has very poor prognosis despite existing multimodal therapies. This study aimed to investigate whether KRAS mutations at codons 12/13 in cell-free DNA (cfDNA) from preoperative and postoperative sera from patients with PDAC can serve as a predictive biomarker for treatment response and outcomes after surgery. METHODS: Preoperative and postoperative serum samples obtained from 45 patients with PDAC whom underwent curative pancreatectomy at our institution between January 2013 and July 2016 were retrospectively analysed. Peptide nucleic acid-directed PCR clamping was used to identify KRAS mutations in cfDNA. RESULTS: Among the 45 patients enrolled, 11 (24.4%) and 20 (44.4%) had KRAS mutations in cfDNA from preoperative and postoperative sera, respectively. Multivariate analysis revealed that KRAS mutations in postoperative serum (hazard ratio (HR)=2.919; 95% confidence interval (CI)=1.109-5.621; P=0.027) are an independent prognostic factor for disease-free survival. Furthermore, the shift from wild-type KRAS in preoperative to mutant KRAS in postoperative cfDNA (HR=9.419; 95% Cl=2.015-44.036; P=0.004) was an independent prognostic factor for overall survival. CONCLUSIONS: Changes in KRAS mutation status between preoperative and postoperative cfDNA may be a useful predictive biomarker for survival and treatment response.

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  • KRAS mutations in cell-free DNA from preoperative and postoperative sera as a pancreatic cancer marker: a retrospective study. Reviewed

    Nakano Y, Kitago M, Matsuda S, Nakamura Y, Fujita Y, Imai S, Shinoda M, Yagi H, Abe Y, Hibi T, Fujii-Nishimura Y, Takeuchi A, Endo Y, Itano O, Kitagawa Y

    British journal of cancer   118 ( 5 )   662 - 669   2018.3

  • 長崎での黄砂が小児気管支喘息患者へ及ぼす影響

    中村 孝裕, 西脇 祐司, 森内 浩幸, 上田 佳代, 清水 厚, 竹内 文乃, 橋爪 真弘

    日本衛生学雑誌   73 ( Suppl. )   S268 - S268   2018.3

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  • Community-wide physical activity intervention based on the Japanese physical activity guidelines for adults: A non-randomized controlled trial. International journal

    Yoshinobu Saito, Yuko Oguma, Ayumi Tanaka, Masamitsu Kamada, Shigeru Inoue, Junko Inaji, Yoshitaka Kobori, Takayuki Tajima, Riri Kato, Yayoi Kibayashi, Yumi Narumi, Ayano Takeuchi, Motohiko Miyachi, I-Min Lee, Toru Takebayashi

    Preventive medicine   107   61 - 68   2018.2

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    Very few community intervention studies that promote physical activity (PA) using guidelines and its dissemination and implementation have been conducted. Consequently, we evaluated the effectiveness of a community-wide intervention (CWI) of PA with adults based on the Japanese guidelines for promoting PA. This was a non-randomized controlled trial, with four administrative districts in Fujisawa city assigned to the intervention group and nine to the control group. The CWI, conducted from 2013 to 2015, comprised information dissemination, education, and community support. The primary outcome was change in PA participation. Secondary outcomes were CWI awareness and PA guideline knowledge. Outcomes were assessed using questionnaires distributed to two independent, random samples of 3000 community-based adults (aged ≥20years). Two separate samples-1230 adults at baseline and 1393 at the two-year follow-up-responded to the survey. The median time spent in PA did not differ between intervention and control groups after adjusting for potential confounders (adjusted difference between groups=-0.02min/day [95% confidence interval (CI): -0.11, 0.10]). However, intervention group participants were more aware of the CWI (33.8%) than were control group participants (25.2%) at the two-year follow-up (odds ratio=1.44 [95% CI: 1.06, 1.95]). A significant difference was also observed in participants' PA guideline knowledge (adjusted difference between groups=0.82% [95% CI: 0.33, 1.31]). Although significant differences in awareness and knowledge were observed between groups, this CWI did not change PA levels over two years. Future studies should investigate the long-term effects of CWIs beyond two years. TRIAL REGISTRATION NUMBER: UMIN-CTR UMIN000018389.

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  • ヨーロッパにおけるトキシコロジスト資格に関して

    竹内 文乃, 古川 賢

    日本毒性学会学術年会   45.1   S3-5   2018

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    <p>トキシコロジストは毒性の検出、機序の解明と化学物質の管理までを含む広い範囲に及ぶ専門的な知識と高い技術を要求される。この基準を満たす専門家を認定するため、日本、アメリカ及びヨーロッパでは、各国の毒性関連学会による認定トキシコロジスト制度が設けられている。アメリカにおける認定トキシコロジスト資格であるDiplomate of the American Board of Toxicology(DABT)については日本においても取得者がおり、よく知られているが、ヨーロッパの認定トキシコロジスト資格についてはあまり知られていない。そこで今回、ヨーロッパの状況について紹介する。</p><p>ヨーロッパにおける認定トキシコロジスト制度は、イギリス(British Toxicology Society:BTS)、ドイツ(Deutschen Gesellschaft für Pharmakologie und Toxikologie:DGPT)、オランダ(Nederlandse Vereniging voor Toxicologie:NVT)、フランス(Société Française de Toxicologie:SFT)等、国ごとに各主催学会で認定される資格と、ヨーロッパ全体としてEUROT

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  • [Exposure Assessment in Japan Environment and Children's Study]

    Nakayama, S. F, Isobe, T, Iwai-Shimada, M, Kobayashi, Y, Oguri, T, Takeuchi, A

    Nihon Eiseigaku Zasshi   73 ( 2 )   156 - 163   2018

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    In this review, we present an initial plan for exposure assessment in the Japan Environment and Children's Study (JECS) by focusing on a biomonitoring technique and discuss the challenges encountered when using the biomonitoring technique for exposure measurements. JECS registered 103,099 pregnant mothers and has been following children born to them. Various biological samples were collected from mothers during pregnancy (blood and urine), at birth (blood and hair) and at check-up one month after birth (breast milk). Samples were also collected from children at birth (cord blood) and at check-up one month after birth (hair and blood spot). Those samples will be used to assess maternal and foetal exposures to chemical substances. Measurement reliability, i.e., intraclass correlation coefficient (ICC), and attenuation bias related to low ICCs should be taken into consideration when using the biomonitoring results. Along with the biomonitoring technique, simulation models, pharmacokinetic (PK) models and exposomics techniques are under development in JECS. New analytical techniques include deciduous teeth measurements and -omics analyses. In particular, PK models and sensor technologies are one of the most important methodologies for future JECS exposure analyses. Statistical methods for examining the effects of intercorrelated multiple exposures as well as nondetection data should also be explored.

    DOI: 10.1265/jjh.73.156

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  • Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry. International journal

    Sei Harada, Akiyoshi Hirayama, Queenie Chan, Ayako Kurihara, Kota Fukai, Miho Iida, Suzuka Kato, Daisuke Sugiyama, Kazuyo Kuwabara, Ayano Takeuchi, Miki Akiyama, Tomonori Okamura, Timothy M D Ebbels, Paul Elliott, Masaru Tomita, Asako Sato, Chizuru Suzuki, Masahiro Sugimoto, Tomoyoshi Soga, Toru Takebayashi

    PloS one   13 ( 1 )   e0191230   2018

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    BACKGROUND: Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enrolling 11,002 community-dwelling adults in Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography-mass spectrometry. The CE-MS method is highly amenable to absolute quantification of polar metabolites, however, its reliability for large-scale measurement is unclear. The aim of this study is to examine reproducibility and validity of large-scale CE-MS measurements. In addition, the study presents absolute concentrations of polar metabolites in human plasma, which can be used in future as reference ranges in a Japanese population. METHODS: Metabolomic profiling of 8,413 fasting plasma samples were completed using CE-MS, and 94 polar metabolites were structurally identified and quantified. Quality control (QC) samples were injected every ten samples and assessed throughout the analysis. Inter- and intra-batch coefficients of variation of QC and participant samples, and technical intraclass correlation coefficients were estimated. Passing-Bablok regression of plasma concentrations by CE-MS on serum concentrations by standard clinical chemistry assays was conducted for creatinine and uric acid. RESULTS AND CONCLUSIONS: In QC samples, coefficient of variation was less than 20% for 64 metabolites, and less than 30% for 80 metabolites out of the 94 metabolites. Inter-batch coefficient of variation was less than 20% for 81 metabolites. Estimated technical intraclass correlation coefficient was above 0.75 for 67 metabolites. The slope of Passing-Bablok regression was estimated as 0.97 (95% confidence interval: 0.95, 0.98) for creatinine and 0.95 (0.92, 0.96) for uric acid. Compared to published data from other large cohort measurement platforms, reproducibility of metabolites common to the platforms was similar to or better than in the other studies. These results show that our CE-MS platform is suitable for conducting large-scale epidemiological studies.

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  • エコチル調査における化学物質曝露評価

    中山 祥嗣, 磯部 友彦, 岩井 美幸, 小林 弥生, 小栗 朋子, 竹内 文乃

    日本衛生学雑誌   73 ( 2 )   156 - 163   2018

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    <p>In this review, we present an initial plan for exposure assessment in the Japan Environment and Children’s Study (JECS) by focusing on a biomonitoring technique and discuss the challenges encountered when using the biomonitoring technique for exposure measurements. JECS registered 103,099 pregnant mothers and has been following children born to them. Various biological samples were collected from mothers during pregnancy (blood and urine), at birth (blood and hair) and at check-up one month after birth (breast milk). Samples were also collected from children at birth (cord blood) and at check-up one month after birth (hair and blood spot). Those samples will be used to assess maternal and foetal exposures to chemical substances. Measurement reliability, i.e., intraclass correlation coefficient (ICC), and attenuation bias related to low ICCs should be taken into consideration when using the biomonitoring results. Along with the biomonitoring technique, simulation models, pharmacokinetic (PK) models and exposomics techniques are under development in JECS. New analytical techniques include deciduous teeth measurements and -omics analyses. In particular, PK models and sensor techn

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  • Validation of rapid algal bioassay using delayed fluorescence in an interlaboratory ring study

    Katsumata, Masakazu, Ikushima, Yuko, Bennett, Keith, Sato, Yukiko, Takeuchi, Ayano, Tatarazako, Norihisa, Hakamata, Tomoyuki

    SCIENCE OF THE TOTAL ENVIRONMENT   605   842 - 851   2017.12

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  • Clinical predictive factors of long-term survival after curative resection of pancreatic cancer: a retrospective study

    Yutaka Nakano, Minoru Kitago, Masahiro Shinoda, Yuta Abe, Hiroshi Yagi, Taizo Hibi, Ayano Takeuchi, Koichi Aiura, Osamu Itano, Yuko Kitagawa

    CANCER MEDICINE   6 ( 10 )   2278 - 2286   2017.10

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    Pancreatic ductal adenocarcinoma (PDAC) continues to have the poorest prognosis of all gastrointestinal malignancies, even after the tumor has been completely resected. However, only a proportion of patients achieve 5-year survival after resection. The factors predictive of achieving 5-year survival remain unclear. The aim of this study was to investigate the pre- and postoperative clinicopathological characteristics of PDAC patients with a &gt;5-year survival after curative resection. We retrospectively reviewed patients who underwent pancreatectomy for PDAC between January 1995 and December 2011. Logistic regression analysis was performed to determine the predictive factors for 5-year survival. One hundred and fifty-one patients were enrolled, including 38 patients with 5-year survival (actual 5-year survival rate, 25.2%). The independent preoperative factors predictive of achieving 5-year survival included serum albumin levels (odds ratio [OR]: 5.06, 95.0% confidence interval [CI]: 1.49-17.19; P=0.009) and neoadjuvant chemoradiotherapy (OR: 3.02, 95.0% CI: 1.00-9.08; P=0.049). Venous infiltration (OR: 2.99, 95.0% CI: 1.09-8.25; P=0.034), liver recurrence (OR: 0.17, 95.0% CI: 0.04-0.69; P=0.013), and perioperative portal vein infusion chemotherapy (OR: 3.06, 95.0% CI: 1.09-8.25; P=0.028) were found to be independent postoperative predictive factors for achieving 5-year survival. Serum albumin levels could be a biomarker for predicting the prognosis of PDAC patients after curative resection. Liver recurrence and perioperative portal vein infusion chemotherapy were independent postoperative factors, suggesting that perioperative portal vein infusion chemotherapy could be promising for improving the survival rate of PDAC patients after curative resection.

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  • Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. International journal

    Kenichi Azuma, Ginji Endo, Yoko Endo, Tetsuhito Fukushima, Kunio Hara, Hajime Hori, Seichi Horie, Hyogo Horiguchi, Masayoshi Ichiba, Gaku Ichihara, Masayuki Ikeda, Tatsuya Ishitake, Akiyoshi Ito, Yuki Ito, Satoko Iwasawa, Michihiro Kamijima, Kanae Karita, Takahiko Katoh, Toshio Kawai, Toshihiro Kawamoto, Reiko Kishi, Shinji Kumagai, Yukinori Kusaka, Akiko Matsumoto, Muneyuki Miyagawa, Hiroyuki Miyauchi, Yasuo Morimoto, Kasuke Nagano, Hisao Naito, Tamie Nakajima, Tetsuo Nomiyama, Hirokazu Okuda, Kazuyuki Omae, Haruhiko Sakurai, Kazuhiro Sato, Tomotaka Sobue, Yasushi Suwazono, Toru Takebayashi, Tatsuya Takeshita, Akito Takeuchi, Ayano Takeuchi, Masatoshi Tanaka, Shigeru Tanaka, Teruomi Tsukahara, Masashi Tsunoda, Susumu Ueno, Jun Ueyama, Yumi Umeda, Yuko Yamano, Takenori Yamauchi, Eiji Yano

    Journal of occupational health   59 ( 4 )   364 - 366   2017.7

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    DOI: 10.1539/joh.17-0148-OP

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  • Risk factors for CKD progression in Japanese patients: findings from the Chronic Kidney Disease Japan Cohort (CKD-JAC) study

    Daijo Inaguma, Enyu Imai, Ayano Takeuchi, Yasuo Ohashi, Tsuyoshi Watanabe, Kosaku Nitta, Tadao Akizawa, Seiichi Matsuo, Hirofumi Makino, Akira Hishida, For The Chronic Kidney Disease Japan Cohort Study Group

    Clinical and Experimental Nephrology   21 ( 3 )   446 - 456   2017.6

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    Background: Chronic kidney disease (CKD) eventually progresses to end-stage renal disease (ESRD). However, risk factors associated with CKD progression have not been well characterized in Japanese patients with CKD who are less affected with coronary disease than Westerners. Methods: A large-scale, multicenter, prospective, cohort study was conducted in patients with CKD and under nephrology care, who met the eligibility criteria [Japanese
    age 20–75 years
    and estimated glomerular filtration rate (eGFR): 10–59 mL/min/1.73 m2]. The primary endpoint was a composite of time to a 50 % decline in eGFR from baseline or time to the initiation of renal replacement therapy (RRT). The secondary endpoints were the rate of decline in eGFR from baseline, time to a 50 % decline in eGFR from baseline, time to the initiation of RRT, and time to doubling of serum creatinine (Cre) concentration. Results: 2966 patients (female, 38.9 %
    age, 60. 3 ± 11.6 years) were enrolled. The incidence of the primary endpoint increased significantly (P &lt
     0.0001) in concert with CKD stage at baseline. The multivariate Cox proportional hazards models revealed that elevated systolic blood pressure (SBP) [hazard ratio (HR) 1.203, 95 % confidence interval (CI) 1.099–1.318)] and increased albumin-to-creatinine ratio (UACR ≥ 1000 mg/g Cre
    HR: 4.523
    95 % CI 3.098–6.604) at baseline were significantly associated (P &lt
     0.0001, respectively) with the primary endpoint. Conclusions: Elevated SBP and increased UACR were risk factors that were significantly associated with CKD progression to ESRD in Japanese patients under nephrology care. UMIN clinical trial registry number: UMIN000020038.

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  • Positive relationship between subsequent chemotherapy and overall survival in pancreatic cancer: Meta-analysis of postprogression survival for first-line chemotherapy

    Akiyoshi Kasuga, Yasuo Hamamoto, Ayano Takeuchi, Kenta Kawasaki, Takeshi Suzuki, Kenro Hirata, Yasutaka Sukawa, Hiromasa Takaishi, Takanori Kanai

    Cancer Chemotherapy and Pharmacology   79 ( 3 )   595 - 602   2017.3

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    Purpose To gain a better understanding of the impact of postprogression survival (PPS) and post-trial anticancer therapy on overall survival (OS) in first-line pancreatic cancer patients. Methods A literature search identified 54 randomized trials, focusing on gemcitabine monotherapy to eliminate effects of heterogeneity of first-line regimens. We evaluated the relation between OS and either progression-free survival (PFS) or PPS. We also examined whether any association might be affected by the year of completion of trial enrollment. Results For all 54 trials, PPS was strongly associated with OS (r = 0.844), whereas PFS was moderately associated with OS (r = 0.623). Average OS and PPS were significantly longer in recent trials than in older trials, (7.29 versus 6.15 months, p &lt
    0.001) and (3.64 versus 2.86 months, p &lt
    0.001), respectively. The correlation between OS and PPS in recent trials was much stronger than that in older trials (r = 0.846 versus 0.729). The relation between OS and PFS in recent and older trials did not differ (r = 0.595 versus 0.563). The percentage of patients with post-trial treatment was significantly higher in recent trials than in older trials (52.7 versus 39.7%, p &lt
    0.001). The rate of posttrial anticancer therapy was significantly associated with OS (r = 0.910). Conclusions We found an increase in median PPS in accordance with an increase in median OS in recent trials compared with older trials and that rate of post-trial anticancer therapy was strongly associated with median OS. It is important that researchers be aware of these findings in designing clinical trials of first-line chemotherapy for pancreatic cancer patients.

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  • Cardiovascular events and death in Japanese patients with chronic kidney disease

    Kenichi Tanaka, CKD-JAC Investigators, Tsuyoshi Watanabe, Ayano Takeuchi, Yasuo Ohashi, Kosaku Nitta, Tadao Akizawa, Seiichi Matsuo, Enyu Imai, Hirofumi Makino, Akira Hishida

    Kidney International   91 ( 1 )   227 - 234   2017.1

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    The incidence of cardiovascular disease (CVD) is higher in patients with chronic kidney disease (CKD) than in the general population, and the risk of CVD increases with reductions in renal function. However, the incidence of CVD in Japanese patients with CKD has not been sufficiently investigated. To measure this we conducted the Chronic Kidney Disease Japan Cohort (CKD-JAC) Study over four years in 2,966 Japanese patients with CKD to examine the incidence of CVD and all-cause death. These patients had an estimated glomerular filtration rate (eGFR) of 10–59 ml/min/1.73 m2, were under nephrologist care, and pooled from 17 medical institutions in Japan. At the median follow-up of 3.9 years, 69 patients had died, 217 had cardiovascular events, and 514 started maintenance dialysis therapy. The incidences of cardiovascular events were 11.9, 19.1, 25.0, and 39.4 per 1,000 person-years at eGFRs of 45–59, 30–44, 15–29, and under 15 ml/min/1.73 m2, respectively. The adjusted Cox proportional hazards models showed that the risk of cardiovascular events increased as the eGFR decreased, with a significant difference only between CKD stage G5 (eGFR: under 15 ml/min/1.73 m2) and CKD stage G3a (eGFR: 45–59 ml/min/1.73 m2) (hazard ratio 3.16, 95% confidence interval 1.28 to 7.76). Thus, the risk of CVD and all-cause death was related to the decrease in eGFR, but not necessarily elevated in proportion to progression of the CKD stage in Japanese patients with predialysis CKD under a nephrologist's care.

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  • Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan

    Kennosuke Tsuda, Takeo Mukai, Sachiko Iwata, Jun Shibasaki, Takuya Tokuhisa, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Akihito Takeuchi, Toshiki Takenouchi, Yuko Araki, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata

    SCIENTIFIC REPORTS   7   39508   2017.1

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    Therapeutic hypothermia is recommended for moderate and severe neonatal encephalopathy, but is being applied to a wider range of neonates than originally envisaged. To examine the clinical use of therapeutic hypothermia, data collected during the first 3 years (2012-2014) of the Baby Cooling Registry of Japan were analysed. Of 485 cooled neonates, 96.5% were &gt;= 36 weeks gestation and 99.4% weighed &gt;= 1,800 g. Severe acidosis (pH &lt; 7 or base deficit &gt;= 16 mmol/L) was present in 68.9%, and 96.7% required resuscitation for &gt; 10 min. Stage II/III encephalopathy was evident in 88.3%; hypotonia, seizures and abnormal amplitude-integrated electroencephalogram were observed in the majority of the remainder. In-hospital mortality was 2.7%; 90.7% were discharged home. Apgar scores and severity of acidosis/encephalopathy did not change over time. The time to reach the target temperature was shorter in 2014 than in 2012. The proportion undergoing whole-body cooling rose from 45.4% to 81.6%, while selective head cooling fell over time. Mortality, duration of mechanical ventilation and requirement for tube feeding at discharge remained unchanged. Adherence to standard cooling protocols was high throughout, with a consistent trend towards cooling being achieved more promptly. The mortality rate of cooled neonates was considerably lower than that reported in previous studies.

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  • 子どもの健康・成長・発達に関する調査への健康心理学からの寄与

    大矢 幸弘, 小西 瑞穂, 目澤 秀俊, 竹内 文乃, 竹中 晃二

    日本健康心理学会大会発表論文集   30   23   2017

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  • 日本の病院における退院支援看護師の実践状況

    戸村 ひかり, 永田 智子, 竹内 文乃, 清水 準一

    日本看護科学会誌   37   150 - 160   2017

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    <p>目的:本研究は2010年と2014年に全国調査を行い,退院支援看護師(DPN)の実践状況を明らかにすることを目的とした.</p><p>方法:全国の100床以上の病院に勤務するDPNに,2010年は819名,2014年は948名に質問紙調査を行った.調査項目はDPNの基本属性,DPNとしての実践能力(Nurses’ Discharge Planning Ability Scale:NDPASの得点)等.</p><p>結果:2010年はDPN461名(回答率56.3%),2014年は479名(50.5%)を分析対象とした.両年とも平均年齢は約47歳で,DPNの平均経験年数は2010年が2.5年,2014年が3.1年であった.また,2014年の方がNDPASの〈A.退院後のケアバランスの見積力〉の得点が高かったが,残り3つの能力の得点については両年で有意差がなかった.</p><p>結論:DPNによる支援の質を保証する為には,系統的・継続的な人材育成の必要性が示唆された.</p>

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  • 美容関連製品の開発で留意すべきエビデンスレベルと信頼区間 : p値よりも信頼区間を (特集 美容製品訴求 : 機能性表示制度をふまえたOK/NG)

    竹内 文乃

    Cosmetic stage / 技術情報協会 編   11 ( 2 )   25 - 31   2016.12

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  • 臨床研究報告 チームで構築した腎移植レシピエントへの定期的栄養指導の効果

    吉田 朋子, 野口 文乃, 佐藤 照子, 池田 成江, 竹内 康雄, 石井 大輔, 吉田 一成

    日本臨床腎移植学会雑誌 = Journal of Japanese Society for Clinical Renal Transplantation   4 ( 2 )   243 - 246   2016.12

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  • Positive relationship between subsequent chemotherapy and overall survival in pancreatic cancer: Meta-analysis of postprogression survival for first-line chemotherapy

    Kasuga, Akiyoshi, Hamamoto, Yasuo, Takeuchi, Ayano, Kawasaki, Kenta, Suzuki, Takeshi, Hirata, Kenro, Sukawa, Yasutaka, Takaishi, Hiromasa, Kanai, Takanori

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   257 - 257   2016.11

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  • Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

    Kota Fukai, Sei Harada, Miho Iida, Ayako Kurihara, Ayano Takeuchi, Kazuyo Kuwabara, Daisuke Sugiyama, Tomonori Okamura, Miki Akiyama, Yuji Nishiwaki, Yuko Oguma, Asako Suzuki, Chizuru Suzuki, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Toru Takebayashi

    PLOS ONE   11 ( 10 )   e0164877   2016.10

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    Objective
    Physical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical activity level and plasma metabo-lites using a targeted metabolomics approach in a population-based study.
    Methods
    A total of 1,193 participants (male, aged 35 to 74 years) with fasting blood samples were selected from the baseline survey of a cohort study. Information on daily total physical activity, classified into four levels by quartile of metabolic equivalent scores, and sedentary behavior, defined as hours of sitting per day, was collected through a self-administered questionnaire. Plasma metabolite concentrations were quantified by capillary electrophoresis mass spectrometry method. We performed linear regression analysis models with multi-variable adjustment and corrected p-values for multiple testing in the original population (n = 808). The robustness of the results was confirmed by replication analysis in a separate population (n = 385) created by random allocation.
    Results
    Higher levels of total physical activity were associated with various metabolite concentrations, including lower concentrations of amino acids and their derivatives, and higher concentrations of pipecolate (FDR p &lt;0.05 in original population). The findings persisted after adjustment for age, body mass index, smoking, alcohol intake, and energy intake.

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  • Erratum to: Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men. Reviewed International journal

    Harada S, Takebayashi T, Kurihara A, Akiyama M, Suzuki A, Hatakeyama Y, Sugiyama D, Kuwabara K, Takeuchi A, Okamura T, Nishiwaki Y, Tanaka T, Hirayama A, Sugimoto M, Soga T, Tomita M

    Environmental health and preventive medicine   21 ( 4 )   283 - 284   2016.7

  • Profiling of plasma metabolites in postmenopausal women with metabolic syndrome. International journal

    Miho Iida, Sei Harada, Ayako Kurihara, Kota Fukai, Kazuyo Kuwabara, Daisuke Sugiyama, Ayano Takeuchi, Tomonori Okamura, Miki Akiyama, Yuji Nishiwaki, Asako Suzuki, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Kouji Banno, Daisuke Aoki, Toru Takebayashi

    Menopause (New York, N.Y.)   23 ( 7 )   749 - 58   2016.7

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    OBJECTIVE: The aim of the study was to investigate the associations of amino acids and other polar metabolites with metabolic syndrome (MetS) in postmenopausal women in a lean Asian population. METHODS: The participants were 1,422 female residents enrolled in a cohort study from April to August 2012. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III modified for Japanese women. Associations were examined between MetS and 78 metabolites assayed in fasting plasma samples using capillary electrophoresis-mass spectrometry. Replication analysis was performed to confirm the robustness of the results in a separate population created by random allocation. RESULTS: Analysis was performed for 877 naturally postmenopausal women, including 594 in the original population and 283 in the replication population. The average age, body mass index, and levels of high- and low-density lipoprotein cholesterol of the entire population were 64.6 years, 23.0 kg/m, 72.1 mg/dL, and 126.1 mg/dL, respectively. There was no significant difference in low-density lipoprotein cholesterol levels between women with and without MetS. Thirteen metabolites were significantly related to MetS: multiple plasma amino acids were elevated in women with MetS, including branched-chain amino acids, alanine, glutamate, and proline; and alpha-aminoadipate, which is generated by lysine degradation, was also significantly increased. CONCLUSIONS: Our large-scale metabolomic profiling indicates that Japanese postmenopausal women with MetS have abnormal polar metabolites, suggesting altered catabolic pathways. These results may help to understand metabolic disturbance, including in persons with normal body mass index and relatively high levels of high-density lipoprotein cholesterol, and may have clinical utility based on further studies.

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  • Erratum to: Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men International journal

    Harada, S, Takebayashi, T, Kurihara, A, Akiyama, M, Suzuki, A, Hatakeyama, Y, Sugiyama, D, Kuwabara, K, Takeuchi, A, Okamura, T, Nishiwaki, Y, Tanaka, T, Hirayama, A, Sugimoto, M, Soga, T, Tomita, M

    Environ Health Prev Med   21 ( 4 )   283 - 284   2016.7

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  • Profiling of plasma metabolites in postmenopausal women with metabolic syndrome

    Iida, M, Harada, S, Kurihara, A, Fukai, K, Kuwabara, K, Sugiyama, D, Takeuchi, A, Okamura, T, Akiyama, M, Nishiwaki, Y, Suzuki, A, Hirayama, A, Sugimoto, M, Soga, T, Tomita, M, Banno, K, Aoki, D, Takebayashi, T

    Menopause   23 ( 7 )   749 - 58   2016.7

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    OBJECTIVE: The aim of the study was to investigate the associations of amino acids and other polar metabolites with metabolic syndrome (MetS) in postmenopausal women in a lean Asian population. METHODS: The participants were 1,422 female residents enrolled in a cohort study from April to August 2012. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III modified for Japanese women. Associations were examined between MetS and 78 metabolites assayed in fasting plasma samples using capillary electrophoresis-mass spectrometry. Replication analysis was performed to confirm the robustness of the results in a separate population created by random allocation. RESULTS: Analysis was performed for 877 naturally postmenopausal women, including 594 in the original population and 283 in the replication population. The average age, body mass index, and levels of high- and low-density lipoprotein cholesterol of the entire population were 64.6 years, 23.0 kg/m, 72.1 mg/dL, and 126.1 mg/dL, respectively. There was no significant difference in low-density lipoprotein cholesterol levels between women with and without MetS. Thirteen metabolites were signific

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  • Meta-analysis of postprogression survival for first-line gemcitabine monotherapy in patients with advanced pancreatic cancer: Positive relationship between subsequent anti-cancer therapy and overall survival.

    Kasuga, Akiyoshi, Hamamoto, Yasuo, Takeuchi, Ayano, Kawasaki, Kenta, Suzuki, Takeshi, Hirata, Kenro, Sukawa, Yasutaka, Takaishi, Hiromasa, Kanai, Takanori

    JOURNAL OF CLINICAL ONCOLOGY   34 ( 15 )   2016.5

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  • The effects of community-wide dissemination of information on perceptions of palliative care, knowledge about opioids, and sense of security among cancer patients, their families, and the general public

    Miki Akiyama, Kei Hirai, Toru Takebayashi, Tatsuya Morita, Mitsunori Miyashita, Ayano Takeuchi, Akemi Yamagishi, Hiroya Kinoshita, Yutaka Shirahige, Kenji Eguchi

    Supportive Care in Cancer   24 ( 1 )   347 - 356   2016.1

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    Purpose: Prejudices against palliative care are a potential barrier to quality end-of-life care. There have been few large-scale community-wide interventions to distribute appropriate information about palliative care, and no studies have investigated their impact on cancer patients, their families, and the general public. Thus, we conducted a 3-year community intervention and evaluated the effects of distributing such information at the community level, and explored associations among levels of exposure, perceptions, knowledge, and the sense of security achieved. Methods: Over a period of 3 years, we provided flyers, booklets, posters, and public lectures about palliative care in four regions of Japan, and carried out pre- and post-intervention surveys with repeated cross-sectional samplings of cancer patients (pre 859, post 857), bereaved family members (1110, 1137), and the general public (3984, 1435). The levels of exposure to the provided information were measured by a multiple-choice questionnaire after intervention. Multiple logistic regression analyses were used to estimate multivariable-adjusted odds ratios (ORs) for perceptions of palliative care, knowledge about opioids, and sense of security among the exposure groups. Results: Overall perceptions of palliative care, opioids, and receiving care at home improved significantly among the general public and families, but not among the patients at the community level. However, multiple regression revealed that patients of extensive exposure category had significantly more positive perceptions of palliative care to those of non-exposure category (p = 0.02). The sense of security regarding cancer care of all patients, family members, and the general public improved. Among others, the respondents who reported extensive exposure in the general public and family members scored significantly higher sense of security. Conclusion: Our findings indicate that providing palliative care information via small media and lectures in the community is effective in improving perceptions of palliative care and knowledge about opioids among the community dwellers, especially for caregivers of the patients. The acquisition of adequate knowledge about palliative care from various information sources may improve people’s sense of security regarding cancer.

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  • Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men. Reviewed International journal

    Harada S, Takebayashi T, Kurihara A, Akiyama M, Suzuki A, Hatakeyama Y, Sugiyama D, Kuwabara K, Takeuchi A, Okamura T, Nishiwaki Y, Tanaka T, Hirayama A, Sugimoto M, Soga T, Tomita M

    Environmental health and preventive medicine   21 ( 1 )   18 - 26   2016.1

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    OBJECTIVE: Metabolomics is a promising approach to the identification of biomarkers in plasma. Here, we performed a population-based, cross-sectional study to identify potential biomarkers of alcohol intake and alcohol-induced liver injury by metabolomic profiling using capillary electrophoresis-mass spectrometry (CE-MS). METHODS: Fasting plasma samples were collected from 896 Japanese men who participated in the baseline survey of the Tsuruoka Metabolomics Cohort Study, and 115 polar metabolites were identified and absolutely quantified by CE-MS. Information on daily ethanol intake was collected through a standardized, self-administered questionnaire. The associations between ethanol intake and plasma concentration of metabolites were examined. Relationships between metabolite concentrations or their ratios and serum liver enzyme levels in the highest ethanol intake group (>46.0 g/day) were then examined by linear regression analysis. Replication analysis was conducted in 193 samples collected from independent population of this cohort. RESULTS: Nineteen metabolites were identified to have an association with daily alcohol consumption both in the original and replication population. Three of these metabolites (threonine, glutamine, and guanidinosuccinate) were found to associate well with elevated levels of serum liver enzymes in the highest ethanol intake group, but not in the non-drinker group. We also found that the glutamate/glutamine ratio had a much stronger relation to serum γ-glutamyltransferase, aspartate transaminase, and alanine transaminase than glutamate or glutamine alone (standardized beta = 0.678, 0.558, 0.498, respectively). CONCLUSIONS: We found 19 metabolites associated with alcohol intake, and three biomarker candidates (threonine, guanidinosuccinate and glutamine) of alcohol-induced liver injury. Glutamate/glutamine ratio might also be good biomarker.

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  • The effects of community-wide dissemination of information on perceptions of palliative care, knowledge about opioids, and sense of security among cancer patients, their families, and the general public. Reviewed

    Akiyama M, Hirai K, Takebayashi T, Morita T, Miyashita M, Takeuchi A, Yamagishi A, Kinoshita H, Shirahige Y, Eguchi K

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer   24 ( 1 )   347 - 356   2016.1

  • Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men

    Harada, S, Takebayashi, T, Kurihara, A, Akiyama, M, Suzuki, A, Hatakeyama, Y, Sugiyama, D, Kuwabara, K, Takeuchi, A, Okamura, T, Nishiwaki, Y, Tanaka, T, Hirayama, A, Sugimoto, M, Soga, T, Tomita, M

    Environ Health Prev Med   21 ( 1 )   18 - 26   2016.1

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    OBJECTIVE: Metabolomics is a promising approach to the identification of biomarkers in plasma. Here, we performed a population-based, cross-sectional study to identify potential biomarkers of alcohol intake and alcohol-induced liver injury by metabolomic profiling using capillary electrophoresis-mass spectrometry (CE-MS). METHODS: Fasting plasma samples were collected from 896 Japanese men who participated in the baseline survey of the Tsuruoka Metabolomics Cohort Study, and 115 polar metabolites were identified and absolutely quantified by CE-MS. Information on daily ethanol intake was collected through a standardized, self-administered questionnaire. The associations between ethanol intake and plasma concentration of metabolites were examined. Relationships between metabolite concentrations or their ratios and serum liver enzyme levels in the highest ethanol intake group (>46.0 g/day) were then examined by linear regression analysis. Replication analysis was conducted in 193 samples collected from independent population of this cohort. RESULTS: Nineteen metabolites were identified to have an association with daily alcohol consumption both in the original and replication population. Three of these metabolites (threonine, glutamine, and guanidinosuccinate) were found to associate well with elevated levels of serum liver enzymes in the highest ethanol intake group, but not in the non-drinker group. We also found that the glutamate/glutamine ratio had a much stronger relation to serum gamma-glutamyltransferase, aspartate transaminase, and alanine transaminase than glutamate or glutamine alone (standardized beta = 0.678, 0.558, 0.498, respectively). CONCLUSIONS: We found 19 metabolites associated with alcohol intake, and three biomarker candidates (threonine, guanidinosuccinate and glutamine) of alcohol-induced liver injury. Glutamate/glutamine ratio might also be good biomarker.

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  • Asian dust and pediatric emergency department visits due to bronchial asthma and respiratory diseases in Nagasaki, Japan Reviewed

    Nakamura T, Hashizume M, Ueda K, Shimizu A, Takeuchi A, Kubo T, Hashimoto K, Moriuchi H, Odajima H, Kitajima T, Tashiro K, Tomimasu K, Nishiwaki Y

    Journal of Epidemiology   26 ( 11 )   593 - 601   2016

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    BACKGROUND: The adverse health effects of Asian dust (AD) on the respiratory system of children are unclear. We hypothesized that AD events may lead to increased visits by children to emergency medical centers due to bronchial asthma and respiratory diseases, including bronchial asthma. METHODS: We used anonymized data on children receiving primary emergency treatment at Nagasaki Municipal Primary Emergency Medical Center, Japan between March 2010 and September 2013. We used Light Detection and Ranging (LIDAR) data to assess AD exposure and performed time-stratified case-crossover analyses to examine the association between AD exposure and emergency department visits. The main analysis was done with data collected from March through May each year. RESULTS: The total number of emergency department visits during the study period was 756 for bronchial asthma and 5421 for respiratory diseases, and the number of "AD days" was 47. In school children, AD events at lag day 3 and lag day 4 were associated with increased emergency department visits due to bronchial asthma, with odds ratios of 1.837 (95% confidence interval [CI], 1.212-2.786) and 1.829 (95% CI, 1.179-2.806), respectively. AD events were significantly associated with respiratory diseases among preschool children at lag day 0, lag day 1, and lag day 2, with odds ratios of 1.244 (95% CI, 1.128-1.373), 1.314 (95% CI, 1.189-1.452), and 1.273 (95% CI, 1.152-1.408), respectively. These associations were also significant when the results were adjusted for meteorological variables and other air pollutants. CONCLUSIONS: The study findings suggested that AD exposure increases emergency department visits by children.

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  • Seasonal Changes in Hospital Admissions for Pulmonary Embolism in Metropolitan Areas of Tokyo (from the Tokyo Cardiovascular Care Unit Network)

    Atsushi Mizuno, Ayano Takeuchi, Takeshi Yamamoto, Yasuhiro Tanabe, Toru Obayashi, Morimasa Takayama, Ken Nagao

    American Journal of Cardiology   116 ( 12 )   1939 - 1943   2015.12

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    Although several studies have shown the relation between temperature/atmospheric pressure and pulmonary embolism (PE), their results are inconsistent. Furthermore, diurnal temperature range (DTR) and diurnal pressure range (DPR) were not fully evaluated for their associations with hospital admissions for PE. Study subjects comprised cases of 1,148 PE treated at institutions belonging to the Tokyo Cardiovascular Care Unit Network from January 2005 to December 2012. Patient data were combined with a variety of daily local climate parameters obtained from the Japan Meteorological Agency. Every 1°C increase in the DTR at lag0 corresponded to an increased relative risk of hospital admission for PE (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.003 to 1.070). In the cooler season (November to April), an increase of 1 hPa (barometric pressure) in the DPR at lag4 and lag5 was associated with an increased relative risk of hospital admission for PE (OR 1.042, 95% CI 1.007 to 1.077 and OR 0.952, 95% CI 0.914 to 0.992, respectively). An increase in the PE hospitalization rate was seen only in the cool season. Using a metropolitan database, we showed that DTR and DPR have different impacts on hospital admissions for PE. In conclusion, we found that an increase in the DTR increases the PE hospitalization rate, especially during the cooler season. The impact of DTR and DPR on PE incidence and related hospitalizations needs to be further evaluated.

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  • Seasonal Changes in Hospital Admissions for Pulmonary Embolism in Metropolitan Areas of Tokyo (from the Tokyo Cardiovascular Care Unit Network). Reviewed

    Mizuno A, Takeuchi A, Yamamoto T, Tanabe Y, Obayashi T, Takayama M, Nagao K, Tokyo CCU Network Scientific Committee

    The American journal of cardiology   116 ( 12 )   1939 - 1943   2015.12

  • P0179-21-PM 移植後患者への指導管理における薬剤師の関与(外来薬剤師業務,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

    宮坂 優人, 小林 昌宏, 稲野 寛, 吉田 一成, 石井 大輔, 竹内 康雄, 池田 成江, 野口 文乃, 田中 美樹, 厚田 幸一郎

    日本医療薬学会年会講演要旨集   25   295   2015.10

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  • A register-based study of the association between air pollutants and hypertensive disorders in pregnancy among the Japanese population

    Takehiro Michikawa, Seiichi Morokuma, Kotaro Fukushima, Kayo Ueda, Ayano Takeuchi, Kiyoko Kato, Hiroshi Nitta

    Environmental Research   142   644 - 650   2015.10

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    Background: Ambient air pollution is hypothesized to be a risk factor for hypertensive disorders in pregnancy, one of the major pregnancy complications. Past studies have reported the supporting evidence, however this mainly referred to the Western population, and results from trimester-specific analysis have been varied. In this study, we focused on exposure during the first trimester of pregnancy (placental development stage), and tested the hypothesis among the Japanese population. Methods: We drew on data from the Japan Perinatal Registry Network database, and studied 36,620 singleton pregnant women without medical complications, in western Japan (Kyushu and Okinawa districts) between 2005 and 2010. In addition, data on ozone, suspended particulate matter (SPM), nitrogen dioxide (NO2), and sulfur dioxide (SO2) concentrations were obtained. The nearest monitoring station to the respective birthing hospital was used as a reference point for assigning average concentrations of each pollutant during the first trimester of pregnancy for each woman. The logistic regression model was applied to assess the association between quintiles of each pollutant and hypertensive disorders in pregnancy. Results: Mean concentrations during the first trimester were 41.3ppb for ozone, 27.4μg/m3 for SPM, 11.8ppb for NO2, and 3.2ppb for SO2. High exposure to ozone was associated with an increased risk of hypertensive disorders in pregnancy (for highest quintile vs. lowest: odds ratio=1.20, 95% confidence interval=1.01-1.42). With regard to SPM, NO2 and SO2, we did not obtain the results with constant directionality. Conclusions: Ozone exposure during early pregnancy may be a risk factor for hypertensive disorders in pregnancy.

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  • A register-based study of the association between air pollutants and hypertensive disorders in pregnancy among the Japanese population Reviewed

    Takehiro Michikawa, Seiichi Morokuma, Kotaro Fukushima, Kayo Ueda, Ayano Takeuchi, Kiyoko Kato, Hiroshi Nitta

    Environmental Research   142   644 - 650   2015.10

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  • Prognostic factors in dogs with protein-losing enteropathy

    K. Nakashima, S. Hiyoshi, K. Ohno, K. Uchida, Y. Goto-Koshino, S. Maeda, N. Mizutani, A. Takeuchi, H. Tsujimoto

    Veterinary Journal   205 ( 1 )   28 - 32   2015.7

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    Canine protein-losing enteropathy (PLE) is associated with severe gastrointestinal disorders and has a guarded to poor prognosis although little information is available regarding factors affecting prognosis. The purpose of this study was to identify the prognostic factors for survival of dogs with PLE. Ninety-two dogs diagnosed with PLE from 2006 to 2011 were included in a retrospective cohort study. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Variables recorded at the time of diagnosis were statistically analysed for possible prognostic factors in a univariate and multivariate Cox proportional hazard model.In the multivariate analysis, the predictors for mortality in dogs with PLE were more highly scored in terms of canine inflammatory bowel disease activity index (CIBDAI) (P = 0.0003), clonal rearrangement of lymphocyte antigen receptor genes (P = 0.003), and elevation of blood urea nitrogen (BUN) (P = 0.03). Using histopathological diagnosis, both small- and large-cell lymphomas were associated with significantly shorter survival times than chronic enteritis (CE) and intestinal lymphangiectasia (IL). Normalization of CIBDAI and plasma albumin concentration within 50 days of initial treatment was associated with a longer survival time. In conclusion, CIBDAI, clonal rearrangement of lymphocyte antigen receptor genes, histopathological diagnosis, and response to initial treatments would be valuable in separating the underlying causes and could be important in predicting prognosis in dogs with PLE.

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  • Prognostic factors in dogs with protein-losing enteropathy. Reviewed

    Nakashima K, Hiyoshi S, Ohno K, Uchida K, Goto-Koshino Y, Maeda S, Mizutani N, Takeuchi A, Tsujimoto H

    Veterinary journal (London, England : 1997)   205 ( 1 )   28 - 32   2015.7

  • <講演3>"Insights from a nationwide children's study"(シンポジウム,Big Data in Psychological Science and Related Disciplines : 心理学と関連諸領域におけるビッグデータ,専修大学神田校舎7号館3階731教室,平成26年9月6日開催)

    竹内, 文乃

    専修大学社会知性開発研究センター/心理科学研究センター年報 : 融合的心理科学の創成 ; 心の連続性を探る   4   80 - 90   2015.3

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  • The Japan Environment and Children's Study (JECS): A preliminary report on selected characteristics of approximately 10 000 pregnant women recruited during the first year of the study Reviewed

    Michikawa T, Nitta H, Nakayama S.F, Ono M, Yonemoto J, Tamura K, Suda E, Ito H, Takeuchi A, Kawamoto T, Saito H, Kishi R, Yaegashi N, Hashimoto K, Yasumura S, Mori C, Hirahara F, Yamagata Z, Inadera H, Kamijima M, Konishi I, Iso H, Shima M, Fukumoto M, Suganuma N, Hara T, Katoh T

    Journal of Epidemiology   25 ( 6 )   452 - 458   2015

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    Background: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study launched in January 2011. In this progress report, we present data collected in the first year to summarize selected maternal and infant characteristics.Methods: In the 15 Regional Centers located throughout Japan, the expectant mothers were recruited in early pregnancy at obstetric facilities and/or at local government offices issuing pregnancy journals. Self-administered questionnaires were distributed to the women during their first trimester and then again during the second or third trimester to obtain information on demographic factors, physical and mental health, lifestyle, occupation, environmental exposure, dwelling conditions, and socioeconomic status. Information was obtained from medical records in the first trimester and after delivery on medical history, including gravidity and related complications, parity, maternal anthropometry, and infant physical examinations.Results: We collected data on a total of 9819 expectant mothers (mean age = 31.0 years) who gave birth during 2011. There were 9635 live births. The selected infant characteristics (singleton births, gestational age at birth, sex, birth weight) in the JECS population were similar to those in national survey data on the Japanese general population.Conclusions: Our final birth data will eventually be used to evaluate the national representativeness of the JECS population. We hope the JECS will provide valuable information on the impact of the environment in which our children live on their health and development.

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  • Impact of short-term exposure to fine particulate matter on emergency ambulance dispatches in Japan Reviewed

    Takehiro Michikawa, Kayo Ueda, Ayano Takeuchi, Makoto Kinoshita, Hiromi Hayashi, Takamichi Ichinose, Hiroshi Nitta

    Journal of Epidemiology and Community Health   69 ( 1 )   86 - 91   2014.9

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  • 位置情報を用いた疫学研究とその統計的方法

    高橋, 邦彦, 和泉, 志津恵, 竹内, 文乃

    統計数理 = Proceedings of the Institute of Statistical Mathematics   62 ( 1 )   3 - 24   2014.6

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  • 観察研究におけるバイアスの感度解析

    竹内, 文乃, 野間, 久史

    統計数理 = Proceedings of the Institute of Statistical Mathematics   62 ( 1 )   77 - 92   2014.6

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  • 地域在住者におけるメタボリック症候群要因の集積と血漿中アミノ酸の関連:鶴岡メタボロームコホート研究

    TOMITA MASARU

    J Epidemiol   24 ( Supplement 1 )   110   2014.1

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  • Sociogeographic Variation in the Effects of Heat and Cold on Daily Mortality in Japan Reviewed

    Chris Fook Sheng Ng, Kayo Ueda, Ayano Takeuchi, Hiroshi Nitta, Shoko Konishi, Rinako Bagrowicz, Chiho Watanabe, Akinori Takami

    JOURNAL OF EPIDEMIOLOGY   24 ( 1 )   15 - 24   2014.1

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    Background: Ambient temperature affects mortality in susceptible populations, but regional differences in this association remain unclear in Japan. We conducted a time-series study to examine the variation in the effects of ambient temperature on daily mortality across Japan.
    Methods: A total of 731 558 all-age non-accidental deaths in 6 cities during 2002-2007 were analyzed. The association between daily mortality and ambient temperature was examined using distributed lag nonlinear models with Poisson distribution. City-specific estimates were combined using random-effects meta-analysis. Bivariate random-effects meta-regressions were used to examine the moderating effect of city characteristics.
    Results: The effect of heat generally persisted for 1 to 2 days. In warmer communities, the effect of cold weather lasted for approximately 1 week. The combined increases in mortality risk due to heat (99th vs 90th percentile of city-specific temperature) and cold (first vs 10th percentile) were 2.21% (95% CI, 1.38%-3.04%) and 3.47% (1.75%-5.21%), respectively. City-specific effects based on absolute temperature changes were more heterogeneous than estimates based on relative changes, which suggests some degree of acclimatization. Northern populations with a cool climate appeared acclimatized to low temperature but were still vulnerable to extreme cold weather. Population density, average income, cost of property rental, and number of nurses appeared to influence variation in heat effect across cities.
    Conclusions: We noted clear regional variation in temperature-related increases in mortality risk, which should be considered when planning preventive measures.

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  • Coarse particulate matter and emergency ambulance dispatches in Fukuoka, Japan: a time-stratified case-crossover study Reviewed

    Takehiro Michikawa, Kayo Ueda, Ayano Takeuchi, Kenji Tamura, Makoto Kinoshita, Takamichi Ichinose, Hiroshi Nitta

    Environmental Health and Preventive Medicine   20 ( 2 )   130 - 136   2014

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  • Rationale and study design of the Japan environment and children's study (JECS) Reviewed

    Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, Yamagata Z, Kayama F, Kishi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata T, Yokoya S, Koresawa Y, Shibata Y, Nakayama S, Michikawa T, Takeuchi A, Satoh H

    BMC Public Health   14 ( 1 )   2014

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    DOI: 10.1186/1471-2458-14-25

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    Other Link: http://orcid.org/0000-0002-6630-8337

  • Decreased duration of acute upper respiratory tract infections with daily intake of fermented milk: a multicenter, double-blinded, randomized comparative study in users of day care facilities for the elderly population. Reviewed International journal

    Retsu Fujita, Satoshi Iimuro, Tomohiro Shinozaki, Kentaro Sakamaki, Yukari Uemura, Ayano Takeuchi, Yutaka Matsuyama, Yasuo Ohashi

    American journal of infection control   41 ( 12 )   1231 - 5   2013.12

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    BACKGROUND: There is insufficient evidence of preventive effect of probiotics on upper respiratory tract infections (URTIs) in an elderly population. METHODS: We conducted a multicenter, double-blinded, randomized, placebo-controlled parallel group study. Elderly persons had participated who used day care at 4 facilities in Tokyo. We used fermented milks containing Lactobacillus casei strain Shirota (LcS) and placebo drinks as test drinks. RESULTS: A total of 154 subjects was analyzed. The number of persons diagnosed with an acute URTIs was almost identical in both groups (LcS: 31, placebo: 32), whereas the number of acute URTIs events (LcS: 68, placebo: 51) and the symptom score (LcS: 425, placebo: 396) were both higher in the LcS group. Permutation tests performed using the total number of acute URTIs infection events/total days of observation and the total symptom score/total days of observation found no statistically significant difference respectively (P values of .89 and .64, respectively). Comparing the mean duration of infection per infection event found a shorter mean duration in the LcS group (LcS: 3.71 days, placebo: 5.40 days), and the difference was statistically significant. CONCLUSION: The results suggest that fermented milk containing LcS probably reduces the duration of acute URTIs.

    DOI: 10.1016/j.ajic.2013.04.005

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  • Seasonal variation in the acute effects of ozone on premature mortality among elderly Japanese Reviewed

    Ng C.F.S, Ueda K, Nitta H, Takeuchi A

    Environmental Monitoring and Assessment   185 ( 10 )   8767 - 8776   2013.4

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    We conducted a multicity time-series study using monitoring data to assess seasonal patterns of short-term ozone-mortality association among elderly aged 65 years and over in Japan. Daily exposure to ambient ozone was computed using hourly measurements of photochemical oxidants available at multiple monitoring stations in each city. Effects of ozone on daily all-cause non-accidental, cardiovascular, and respiratory mortality were estimated using distributed lag linear models, controlling for confounding by temporal, day of the week, temperature, and flu epidemics. City-level effect estimates were combined using inverse variance meta-analysis. In spring and autumn, a 10-ppbv increase of daily maximum 8-h average ozone concentration in the previous 3 days was associated with 0.69 % (95 % confidence interval (CI): 0.27-1.10), 1.07 % (0.34-1.82), and 1.77 % (0.78-2.77) increases in daily all-cause, cardiovascular, and respiratory mortality, respectively. Forward displacement of respiratory mortality was large during the cold season despite lower ozone concentration. Results were generally independent of fine particulate matter and nitrogen dioxide. Findings suggest significant mortality effects of short-term ozone exposure among the elderly during the moderate season. Those with underlying respiratory diseases were susceptible, even during winter. © 2013 Springer Science+Business Media Dordrecht.

    DOI: 10.1007/s10661-013-3211-6

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    Other Link: http://orcid.org/0000-0003-1025-0807

  • Characteristics of neuropsychological functions in inpatients with poorly-controlled type 2 diabetes mellitus

    Ai Takeuchi, Eisuke Matsushima, Motoichiro Kato, Mika Konishi, Hajime Izumiyama, Yuji Murata, Yukio Hirata

    JOURNAL OF DIABETES INVESTIGATION   3 ( 3 )   325 - 330   2012.6

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    Aims/Introduction: It has been suggested that type 2 diabetes is associated with cognitive impairment. We investigated the neuropsychological profile of inpatients with poorly controlled type 2 diabetes and assessed the effects of clinical factors on neuropsychological functions. Materials and Methods: Forty-two patients with type 2 diabetes and 32 non diabetic control subjects were matched for age, sex ratio, and level of education. Attention & working memory, processing speed, verbal memory, visuospatial memory, visuoconstruction, and executive function were tested. Information about physical function, alcohol use, hypertension, dyslipidemia, and myocardial infarction was retrieved from personal interviews and medical records. Results: Diabetic patients demonstrated mild cognitive deterioration in attention & working memory, processing speed, verbal memory, and executive function. In particular, neuropsychological decline became prominent when tasks related with speed and verbal stimuli became unstructured and complex. Age was significantly associated with the majority of neuropsychological tests, whereas tasks dealing with working memory and executive function were associated with age only in the diabetic group. Duration of diabetes was associated with Backward Digit Span. Conclusions: Accelerated aging had a major influence on cognitive decline in the diabetic group, whereas diminished performance in working memory and executive function might have been more related to diabetes-related cognitive impairment. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00170.x, 2011)

    DOI: 10.1111/j.2040-1124.2011.00170.x

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  • A direct role for Hsp90 in pre-RISC formation in Drosophila

    Tomohiro Miyoshi, Akiko Takeuchi, Haruhiko Siomi, Mikiko C. Siomi

    NATURE STRUCTURAL & MOLECULAR BIOLOGY   17 ( 8 )   1024 - 1026   2010.8

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    Heat-shock proteins (Hsps) are molecular chaperones that control protein folding and function. Argonaute 2 (Ago2), the effector in RNA interference (RNAi), is associated with Hsp90; however, its function in RNAi remains elusive. Here we show that Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complex-loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex.

    DOI: 10.1038/nsmb.1875

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  • Estimating Mortality Effects of Fine Particulate Matter in Japan: A Comparison of Time-Series and Case-Crossover Analyses Reviewed

    Kayo Ueda, Hiroshi Nitta, Masaji Ono, Ayano Takeuchi

    JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION   59 ( 10 )   1212 - 1218   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AIR & WASTE MANAGEMENT ASSOC  

    Small particles can reach alveoli without being trapped in the upper respiratory tract and may have a greater impact on health than larger particles. Given the limited knowledge on health effects of fine particulate matter (PM(2.5)) in Japan, the short-term effects of PM(2.5) on daily mortality using the generalized additive model (GAM), generalized linear model (GLIM), and time-stratified case-crossover analysis were estimated. Daily mortality data were obtained from the Ministry of Health, Labor, and Welfare. Air pollution and meteorological data in 20 areas were obtained from the National Institute for Environmental Studies and the Japan Meteorological Agency, respectively. The three methods were compared, adjusting for meteorological variables and co-pollutants, for area-specific analyses and combined area-specific results using meta-analysis with a random-effects model. Daily mortality for elderly aged 65 and over varied from 0.5 to 127.3 by area. The 24-hr mean concentration of PM(2.5) ranged from 11.8 to 22.8 mu g/m(3). Area-specific analyses revealed regional heterogeneity. Furthermore, combined results showed that a 10-mu g/m(3) increase in PM(2.5) for the single-pollutant model at lag1 was associated with a 0.53, 0.77, and 0.88% increase in all-cause mortality for the GAM, GLIM, and case-crossover analysis, respectively. These findings provide robust evidence for the short-term effects of air pollutants on daily mortality in Japan and suggest that differences in estimates obtained from different statistical models should be considered when multipollutant models are used.

    DOI: 10.3155/1047-3289.59.10.1212

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  • Phylogenetic position of a deep-sea ascidian, Megalodicopia hians, inferred from the molecular data

    A Kurabayashi, M Okuyama, M Ogawa, A Takeuchi, Z Jing, T Naganuma, Y Saito

    ZOOLOGICAL SCIENCE   20 ( 10 )   1243 - 1247   2003.10

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    Ascidians inhabit both shallow water and the deep sea. The phylogenetic position of deep-sea ascidians has not been sufficiently investigated because of their unusual habitats. The family Octacnemidae is one such enigmatic deep-sea ascidian. In this report, we determined the sequences of the 18SrDNA and a mitochondrial protein gene of Megalodicopia hians belonging to the family Octacnemidae, and we analyzed its phylogenetic relationship with other ascidians. A phylogenetic relationship of this family with the families Cionidae and/or Corellidae has been suspected based on a small number of morphological characteristics. However, our results suggested that M. hians has a close relationship to the family Corellidae and might originate from them. This is the first report of the molecular phylogenetic analysis of a deep-sea ascidian.

    DOI: 10.2108/zsj.20.1243

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  • Morphological studies on the bathyal ascidian, Megalodicopia hians Oka 1918 (Octacnemidae, Phlebobranchia), with remarks on feeding and tunic morphology Reviewed

    Okuyama, M, Saito, Y, Ogawa, M, Takeuchi, A, Jing, Z, Naganuma, T, Hirose, E

    ZOOLOGICAL SCIENCE   19 ( 10 )   1181 - 1189   2002.10

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    Megalodicopia hians Oka is a solitary ascidian belonging to the family Octacnemidae inhabiting the bathyal/abyssal zone as well as other octacnemid ascidians. The phylogenetic relationship of octacnemids is open to argument because of its extraordinary morphological features due to habitat adaptation, e.g., a pharynx lacking ciliated stigmata. Aggregations of M. hians were discovered by the manned submersible Shinkai 2000 in the bathyal seafloor of Toyama Bay, Japan Sea, in 2000; this was the first in situ observation of M. hians in the Japanese coastal waters. In 2001, a total of 36 M. hians specimens were collected from the bay (592-978 m deep). In situ observation indicated that M. hians usually opens its large oral apertures to engulf the drifting food particles in the water current. Microscopical observation of the gut contents also showed that M. hians is a non selective macrophagous feeding on small crustaceans, diatoms, detritus, and so on. Along with the position of the intestinal loop and gonad, the morphological characteristics of the tunic (integument of ascidians) suggest that M. hians is closely related to Cionidae and/or Corellidae. Some symbiotic/parasitic organisms

    DOI: 10.2108/zsj.19.1181

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    Other Link: http://dl.ndl.go.jp/info:ndljp/pid/10865067

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Books

  • Handbook of Mathematics and Statistics for the Environment

    住 明正, 監修, 原澤 英夫( Role: Contributor)

    朝倉書店  2017.9  ( ISBN:9784787820532

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    Language:Japanese   Book type:Dictionary, encyclopedia

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  • 放射線 必須データ32:被ばく影響の根拠

    Tanaka Shiro, Tsunoyama Yuichi, Takeuchi Ayano( Role: Joint author)

    創元社  2016.3  ( ISBN:4422410903

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    Language:Japanese   Book type:Scholarly book

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  • 保健医療従事者のためのマルチレベル分析活用ナビ

    藤野 善久, 近藤 尚己, 竹内 文乃( Role: Joint author)

    診断と治療社  2013.9  ( ISBN:4787820532

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  • 保健師・保健師をめざす学生のためのなぜ?どうして?〈4〉疫学・保健統計

    Sato Hiroki, Takeuchi Ayano, Tomotaki Ai( Role: Supervisor (editorial))

    メディックメディア  2011.1  ( ISBN:4896323602

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MISC

  • 非糖尿病症例における分枝鎖アミノ酸と脂質代謝異常症との関連性

    福島 敬子, 原田 成, 竹内 文乃, 栗原 綾子, 飯田 美穂, 深井 航太, 桑原 和代, 加藤 寿寿華, 松元 美奈子, 平田 あや, 秋山 美紀, 杉山 大典, 岡村 智教, 武林 亨

    日本動脈硬化学会総会プログラム・抄録集   51回   2 - P   2019.7

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    Language:Japanese   Publisher:(一社)日本動脈硬化学会  

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  • Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity. International journal

    Atsuko Araki, Kenichi Azuma, Ginji Endo, Yoko Endo, Tetsuhito Fukushima, Kunio Hara, Hajime Hori, Seichi Horie, Hyogo Horiguchi, Masayoshi Ichiba, Gaku Ichihara, Masayuki Ikeda, Tatsuya Ishitake, Akiyoshi Ito, Yuki Ito, Satoko Iwasawa, Takeyasu Kakumu, Michihiro Kamijima, Kanae Karita, Takahiko Katoh, Toshio Kawai, Toshihiro Kawamoto, Shinji Kumagai, Yukinori Kusaka, Akiko Matsumoto, Muneyuki Miyagawa, Hiroyuki Miyauchi, Yasuo Morimoto, Kasuke Nagano, Hisao Naito, Tamie Nakajima, Makiko Nakano, Tetsuo Nomiyama, Hirokazu Okuda, Masayuki Okuda, Kazuyuki Omae, Haruhiko Sakurai, Kazuhiro Sato, Tomotaka Sobue, Yasushi Suwazono, Toru Takebayashi, Tatsuya Takeshita, Akito Takeuchi, Ayano Takeuchi, Masatoshi Tanaka, Shigeru Tanaka, Teruomi Tsukahara, Masashi Tsunoda, Susumu Ueno, Jun Ueyama, Yumi Umeda, Kenya Yamamoto, Yuko Yamano, Takenori Yamauchi, Eiji Yano

    Journal of occupational health   60 ( 4 )   333 - 335   2018.7

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    Language:English   Publisher:Journal of Occupational Health  

    DOI: 10.1539/joh.2018-0137-OP

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  • 長崎での黄砂が小児気管支喘息患者へ及ぼす影響

    中村孝裕, 西脇祐司, 森内浩幸, 上田佳代, 清水厚, 竹内文乃, 橋爪真弘

    日本衛生学雑誌(Web)   73 ( Supplement )   S268   2018.3

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    Language:Japanese  

    J-GLOBAL

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  • 長崎での黄砂が小児気管支喘息患者へ及ぼす影響

    中村 孝裕, 西脇 祐司, 森内 浩幸, 上田 佳代, 清水 厚, 竹内 文乃, 橋爪 真弘

    日本衛生学雑誌   73 ( Suppl. )   S268 - S268   2018.3

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  • P-90 A study design of 3-year cohort study of air pollution and lung function growth among schoolchildren(Poster session)

    TAKEBAYASHI Toru, ASAKURA Keiko, NITTA Hiroshi, TAKEUCHI Ayano, UEDA Kayo, ODAJIMA Hiroshi, HASEGAWA Shuichi, TSUKAHARA Teruomi, KONNO Satoshi, MORIKAWA Miki, MUKAI Yasufumi, YOSHIMURA Takesumi

    ( 53 )   320 - 320   2012

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Awards

  • 日本疫学会ポスター賞

    2012.1   日本疫学会  

  • 日本計量生物学会奨励賞

    2011.9   日本計量生物学会  

Research Projects

  • アドバンス・ケア・プランニングを始める時期が客観的にわかる方法の開発と効果の検証

    2022.4 - 2026.3

    University of Tsukuba  Grant-in-Aid for Scientific Research (B) 

    浜野 淳

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    Grant type:Competitive

    Grant amount: \16900000 ( Direct Cost: \13000000 、 Indirect Cost: \3900000 )

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  • アドバンス・ケア・プランニングを始める時期が客観的にわかる方法の開発と効果の検証

    2019.4 - 2023.3

    University of Tsukuba  Grant-in-Aid for Scientific Research (B) 

    浜野 淳

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    Grant type:Competitive

    Grant amount: \15210000 ( Direct Cost: \11700000 、 Indirect Cost: \3510000 )

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  • 大規模環境疫学研究のためのライフコース統計解析手法の重点的開発と実データ適用

    2019.4 - 2023.3

    Keio University  Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B) 

    竹内 文乃

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount: \8320000 ( Direct Cost: \6400000 、 Indirect Cost: \1920000 )

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  • 小児環境疫学研究に適用するライフコースアプローチの重点的な開発

    2020.3 - 2022.3

    Keio University  Grant-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A)) 

    竹内 文乃

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount: \6110000 ( Direct Cost: \4700000 、 Indirect Cost: \1410000 )

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  • 日米間の代謝プロファイルに基づくBMIを表現する代謝マーカーの解明

    2019.4 - 2022.3

    Keio University  Grant-in-Aid for Scientific Research (C) 

    栗原 綾子

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    Grant type:Competitive

    Grant amount: \4420000 ( Direct Cost: \3400000 、 Indirect Cost: \1020000 )

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  • ゲノム・メタボローム・コホートによる肝障害発症経路の解明と個別的予防医療への応用

    2018.7 - 2022.3

    Keio University  Grant-in-Aid for Scientific Research (C) 

    原田 成

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    Grant type:Competitive

    Grant amount: \4550000 ( Direct Cost: \3500000 、 Indirect Cost: \1050000 )

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  • Development life course approach to birth cohort study

    2017.4 - 2020.3

    Keio University  Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B) 

    竹内 文乃

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount: \4160000 ( Direct Cost: \3200000 、 Indirect Cost: \960000 )

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  • Metabolome-wide metabolic profiling and non-communicable disease prevention in a population-based cohort study

    2015.4 - 2019.3

    Keio University  Grant-in-Aid for Scientific Research (B) 

    武林 亨

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    Grant type:Competitive

    Grant amount: \15470000 ( Direct Cost: \11900000 、 Indirect Cost: \3570000 )

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  • 統計数理研究所平成28年度公募型共同利用

    2016.4 - 2017.3

    統計数理研究所 

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  • 平成28年厚生労働科学研究委託費

    2016.4 - 2017.3

    厚生労働省  Health and Labour Sciences Research Grants 

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  • Development of statistical method for case-cohort design when measurements of interests are known to be missing

    2013.4 - 2017.3

    Oita University  Grant-in-Aid for Scientific Research (C) 

    和泉 志津恵

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    Grant type:Competitive

    Grant amount: \4810000 ( Direct Cost: \3700000 、 Indirect Cost: \1110000 )

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  • 統計数理研究所平成27年度公募型共同利用

    2015.4 - 2016.3

    統計数理研究所 

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  • 平成27年厚生労働科学研究委託費

    2015.4 - 2016.3

    厚生労働省  Health and Labour Sciences Research Grants 

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  • Metabolite profiles and age-related macular degeneration

    2014.4 - 2016.3

    Toho University  Grant-in-Aid for Challenging Exploratory Research 

    西脇 祐司

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    Grant type:Competitive

    Grant amount: \3770000 ( Direct Cost: \2900000 、 Indirect Cost: \870000 )

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  • H26厚生労働科学研究費補助金

    2014.4 - 2015.3

    厚生労働省  Health and Labour Sciences Research Grants 

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  • 平成26年厚生労働科学研究委託費

    2014.4 - 2015.3

    厚生労働省  Health and Labour Sciences Research Grants 

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Teaching Experience

  • 応用生物統計学

    Institution:Keio University

  • 基礎生物統計学2

    Institution:Keio University

  • 疫学研究の統計的方法

    Institution:Keio University

  • 基礎生物統計学1

    Institution:Keio University

  • 応用生物統計学

  • 基礎生物統計学2

  • 基礎生物統計学1

  • 基礎生物統計学Ⅱ

  • STATISTICAL METHODS IN EPIDEMIOLOGY

    Institution:Keio University

  • STATISTICAL METHODS IN EPIDEMIOLOGIC RESEARCH

    Institution:Keio University

  • PUBLIC HEALTH

    Institution:Keio University

  • MEDICAL PROFESSIONALISM 5

    Institution:Keio University

  • INTRODUCTORY BIOSTATISTICS1

    Institution:Keio University

  • INTRODUCTORY BIOSTATISTICS 2

    Institution:Keio University

  • INTERMEDIATE BIOSTATISTICS

    Institution:Keio University

  • FUNDAMENTALS OF ENVIRONMENTAL AND OCCUPATIONAL HEALTH

    Institution:Keio University

  • ENVIRONMENTAL AND OCCUPATIONAL HEALTH

    Institution:Keio University

  • BIOSTATISTICS AND MEDICAL INFORMATICS

    Institution:Keio University

  • 疫学研究の統計的方法

  • 公衆衛生学

  • メディカル・プロフェッショナリズムⅤ

  • 基礎生物統計学Ⅰ

  • 環境・産業保健学

  • 衛生学

  • 医学統計・医療情報

  • PUBLIC HEALTH 2 (ADVANCED)

    Institution:Keio University

  • PUBLIC HEALTH 1 (BASIC)

    Institution:Keio University

  • EPIDEMIOLOGY AND PREVENTIVE MEDICINE

    Institution:Keio University

  • 公衆衛生学Ⅱ

  • 公衆衛生学Ⅰ

  • 衛生学Ⅰ

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Committee Memberships

  • 2017 - Now

    国立成育医療研究センター「牛乳アレルギー治療(経口免疫療法)に対する有効性および安全性検証試験(乳酸菌発酵果汁飲料を用いた二重盲検プラセボ対照並行群間比較試験)」   効果安全性評価委員  

  • 2015 - Now

    環境省「子どもの環境と健康に関する全国調査小児食事票開発プロジェクト委員会」   委員