Updated on 2025/05/04

写真a

 
UENO Yuko
 
Organization
Faculty of Science and Engineering Professor
Other responsible organization
Applied Chemistry Course of Graduate School of Science and Engineering, Master's Program
Applied Chemistry Course of Graduate School of Science and Engineering, Doctoral Program
Contact information
The inquiry by e-mail is 《here
External link

Degree

  • D. Sc. ( The University of Tokyo )

  • M. Sc. ( The University of Tokyo )

Education

  • 1997.3
     

    The University of Tokyo   School of Science   Department of Chemistry   master course   completed

  • 1995.3
     

    The University of Tokyo   School of Science   Department of Chemistry   graduated

Research History

  • 2020.4 -  

    Chuo University   "Faculty of Science and Engineering, Department of Applied Chemistry"   Professor

  • 2020.4 -  

    Chuo University   Faculty of Science and Engineering, Department of Applied Chemistry   Professor

  • 2019.7 - 2020.3

    NTT物性科学基礎研究所   グループリーダー

  • 2018.4 - 2020.3

    NTT Basic Research Laboratories   Distinguished Scientist

  • 1997.4 - 2020.3

    NTT R&D

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Professional Memberships

  • American Chemical Society

  • 日本化学会

  • 日本分析化学会

  • 日本分光学会

  • 応用物理学会

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Research Interests

  • molecular spectroscopy

  • Physical chemistry

  • biosensor

  • Micro nano chemistry

  • chemical sensor

  • Analytical chemistry

  • molecular structure

Research Areas

  • Nanotechnology/Materials / Nano/micro-systems  / Nano/Microsystems

Papers

  • Structural and Mechanical Characterization of DNA-Tethered Membranes on Graphene

    Akihisa Yamamoto, Yusuke Sakamaki, Wasim Abuillan, Oleg Konovalov, Yuko Ueno, Motomu Tanaka

    Langmuir   2024.8

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.langmuir.4c01957

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  • Redox Cycling in Microgap Monolayer Graphene Electrodes Made Without Using a Microfabrication Process Reviewed

    Satomi Onuki, Yuko Ueno

    Sensors and Materials   35 ( 10 )   4789 - 4789   2023.10

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:MYU K.K.  

    DOI: 10.18494/sam4566

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  • Electrochemical analysis of ferrocene in bicontinuous microemulsions using beta- cyclodextrin modified monolayer graphene electrodes Reviewed

    Sho Narafu, Yoshinori Takashima, Osamu Niwa, Tatsuhiko Yajima, Yuko Ueno

    JOURNAL OF ELECTROANALYTICAL CHEMISTRY   920   116575   2022.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE SA  

    A monolayer graphene electrode modified with beta-cyclodextrin (beta-CD) was produced via a one-step reaction using an originally synthesized pyrene derivative of beta-CD (py-beta-CD). A py-beta-CD-modified graphene electrode with a high modification density exceeding a coverage of 0.5 was obtained. Using this electrode, the electro-chemical behaviors of water-insoluble ferrocene (Fc) and of a water-soluble ferrocene derivative in a bicontin-uous microemulsion (BME) solution, consisting of a phosphate buffer (pH = 7.4), sodium dodecyl sulfate (SDS), 2-butanol, and toluene, were analyzed to investigate the effects of beta-CD modification on the redox reac-tions of these species. In the reduction reaction of water-insoluble Fc, almost no peak was observed for the unmodified graphene electrode, whereas a high peak current increase was observed for the beta-CD-modified elec-trode. The mechanism of the increase in the peak current of the reduction reaction can be derived from many small water domains formed around the beta-CD molecules on the graphene surface. These water domains form many oil-water interfaces on the surface of the graphene electrode, which act as an [Fc]+1 concentration field by interacting with SDS.

    DOI: 10.1016/j.jelechem.2022.116575

    Web of Science

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  • Graphene-Based FRET Aptasensors. Invited Reviewed

    Yuko Ueno

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   37 ( 3 )   439 - 446   2021.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Graphene-based FRET aptasensors can be realized only by unique combinations of aptamer that can be freely functionalized by chemical modification, and graphene/graphene oxide that works as an excellent fluorescence acceptor at the same time as aptamer adsorbates. This review describes the principles of the sensor, several applications to microchannel devices, improvement of the sensing performance by molecular design of the aptamer and remarks on future prospects based on an introduction of recent works and achievements, including the author's paper. The sensor employs DNA modified with graphene/graphene oxide at the terminal as the molecular probe. This system is supported by the excellent property of DNA that does not lose the molecular recognition ability even due to a chemical modification at the terminal. I hope that this review will be useful for developing research on higher performance of graphene aptasensors in the future.

    DOI: 10.2116/analsci.20SCR08

    PubMed

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  • Tough, permeable and biocompatible microfluidic devices formed through the buckling delamination of soft hydrogel films. Reviewed International journal

    Riku Takahashi, Hiroki Miyazako, Aya Tanaka, Yuko Ueno, Masumi Yamaguchi

    Lab on a chip   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Microchannels in soft materials play an important role in developing movable, deformable, and biocompatible fluidic systems for applications in various fields. Intensively investigated approaches to create microscale channel architectures use mechanical instability in soft materials, which can provide intricate yet ordered architectures with low cost and high throughput. Here, for microchannel fabrication, we demonstrate the use of swelling-driven buckle delamination of hydrogels, which is a mechanical instability pattern found in compressed film/substrate layer composites. By spatially controlling interfacial bonding between a thin polyacrylamide (PAAm) gel film and glass substrate, swelling-driven compressive stress induces buckle delamination at programmed positions, resulting in the formation of continuous hollow paths as microchannels. Connecting flow tubes with a 3D-printed connecter provides a deformable microfluidic device, enabling pressure-driven flows without leakage from the connecter and rupture of the channels. Furthermore, by stacking less-swellable bulk gels on the device, we obtained a tough, permeable, and biocompatible microfluidic device. Finally, we performed a cell culture on the device and chemical stimulation to cells through the diffusion of molecules from the microchannels. The results of this work shed light on designing pressure sensitive/resistant microfluidic systems based on diverse hydrogels with intricate 3D morphologies and will be useful for applications in the fields of bioanalysis, biomimetics, tissue engineering, and cell biology.

    DOI: 10.1039/d0lc01275k

    PubMed

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Books

  • Chemical, Gas, and Biosensors for the Internet of Things and Related Applications

    K. Mitsubayashi, O. Niwa, Y. Ueno( Role: Joint editor)

    Elsevier  2019.6  ( ISBN:9780128154090

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    Total pages:406   Language:English   Book type:Scholarly book

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  • Encyclopedia of Spectroscopy and Spectrometry 3rd Edition

    K. Ajito, M. Nakamura, T. Tajima, Y. Ueno( Role: ContributorChapter 18 Terahertz Spectroscopy Methods and Instrumentation)

    Academic Press,Elsevier  2016.10  ( ISBN:9780128032244

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    Total pages:3584   Responsible for pages:432-437   Language:English   Book type:Scholarly book

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  • Handbook of Terahertz Technologies: Devices and Applications

    Y. Ueno, K. Ajito( Role: ContributorChapter 15 THz chemical spectroscopy)

    Jenny Stanford Publishing  2015.3  ( ISBN:9814613088

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    Total pages:612   Language:English   Book type:Scholarly book

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MISC

  • Reaction promotion effect of potassium ions in monolayer graphene electrodes

    上野祐子, 後藤秀樹

    生体医歯工学共同研究拠点成果報告書   2023   2024

  • 蛍光型酸化グラフェンバイオセンサの積層数と還元状態に依存する応答特性の変化

    木島里緒, 上野祐子

    日本分析化学会年会講演要旨集(Web)   72nd   2023

  • ポリアクリルアミド修飾単層グラフェン表面に形成した二次元支持膜における流動性の評価

    鹿間祐希, 大嶋梓, 一山巽, 片岡直輝, 兼子綺人, 小貫聖美, 山口真澄, 上野祐子, 上野祐子

    日本分析化学会年会講演要旨集(Web)   72nd   2023

  • ピレン骨格で表面機能化された巨大ベシクルとグラフェン表面との相互作用

    兼子綺人, 上野祐子

    日本分析化学会年会講演要旨集(Web)   72nd   2023

  • 単層グラフェン表面に吸着したDPPZによる[Fe(CN)6]3-/4-の還元反応における電荷移動の促進

    鈴木涼平, HAN HuamWen, 山下一郎, 上野祐子

    日本分析化学会年会講演要旨集(Web)   72nd   2023

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Presentations

  • Chemical/Bio-sensors using monolayer graphene and its derivative materials

    Yuko Ueon

    NCU/CHUO Chemistry Workshop  2025.1 

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    Language:English   Presentation type:Oral presentation (general)  

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  • Electrochemical enhancement effect of 1,10-phenanthroline adlayer formed on a monolayer graphene substrate

    Narutaka Kajiwara, Soichiro Yoshimoto, Yuko Ueno, Chuo University, Kumamoto Univer

    34th Annual Meeting of MRS  2024.12 

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    Language:English   Presentation type:Poster presentation  

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  • Interaction of giant vesicles containing pyrene-modified lipids with graphene substrates Invited

    Ayato Kaneko, Yuko Ueno

    17th International Symposium on Nanomedicine  2024.12 

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    Language:English   Presentation type:Oral presentation (invited, special)  

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  • Detection of vitamins using a monolayer graphene electrode integrated with a bicontinuous microemulsions-based gel

    A. Shiuchi, Y. Ueno

    The 15th Asian Conference On Chemical Sensors  2024.11 

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    Language:English   Presentation type:Poster presentation  

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  • Creation of liposomes encapsulating hydrophobic fluorescent dyes as a molecular concentrator for highly sensitive detection

    Y. Katsuwata, Y. Ueno

    The 15th Asian Conference On Chemical Sensors  2024.11 

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    Language:English   Presentation type:Poster presentation  

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Awards

  • Seiyama Award

    2022   Japan Association of Chemical Sensors  

    上野 祐子

  • 日本分析化学会女性Analyst賞

    2019   JSAC  

    上野 祐子

  • Bio4Apps Best Presentation Award

    2017   Bio4Apps  

  • 分光イノベーション賞

    2014   分光学イノベーション研究会  

  • 東京コンファレンス優秀ポスター賞

    2009   日本分析化学会,JAIMA  

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Research Projects

  • グラフェン表面修飾を利用した多種プローブ搭載マイクロ粒子による物質分離機能

    Grant number:22K04899  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)  中央大学

    上野 祐子

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    Grant amount: \4160000 ( Direct Cost: \3200000 、 Indirect Cost: \960000 )

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  • 水圏環境下でイオン・分子認識機能を発現するグラフェン機能材料の開拓

    Grant number:20H05238  2020.4 - 2022.3

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)  中央大学

    上野 祐子

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    Grant amount: \4550000 ( Direct Cost: \3500000 、 Indirect Cost: \1050000 )

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  • 筒状マイクロエンベロープ内壁に構築するグラフェンバイオインターフェース

    Grant number:17H02759  2017.4 - 2020.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)  日本電信電話株式会社NTT物性科学基礎研究所

    上野 祐子, 手島 哲彦

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    Grant amount: \17680000 ( Direct Cost: \13600000 、 Indirect Cost: \4080000 )

    本研究の目的は,分子や細胞を内包可能な筒状マイクロエンベロープを作製し,エンベロープの内壁に,分子認識場として動作する生体分子インターフェースを構築することにより,内部の中空空間に閉じ込められた生体分子を高感度にかつ選択的に検出する,新規プラットフォームを確立することである.これにより,従来は物質の拡散により単利同定が困難であった,生きた細胞から放出される分泌物などの検出が可能となる.
    本年度は,グラフェン/ポリパラキシレン/シルクフィブロインゲル/アルギン酸ゲルという生体適合性の高い高分子層で構成された積層膜を用いて,最上層のグラフェン表面にアプタマを修飾する方法および,グラフェンを最内層とする筒状マイクロエンベロープを安定に構築する条件を確立した.シルクフィブロインゲルは,合成条件や個体差による硬さや厚さのばらつきが比較的大きく,精密制御の際に課題となることが分かったため,この層を,生体適合性を有するより安定で制御しやすい材料に置換する検討を行った.このようにして作製した,グラフェンを最内層とする筒状マイクロエンベロープの内部に,複数種類の細胞を内包し,数日程度の培養に成功した.さらに,細胞外分泌物の検出を想定した培養環境下において,センシングのバックグラウンドを上昇させる妨害成分およびその影響の大きさを定量的に確認した.
    これらの成果について,招待講演を含む国内外の学会および論文発表を行った.

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  • Quantitative evaluation of energy transfer efficiency to graphene and its derivatives

    Grant number:26286018  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B) 

    Furukawa Kazuaki

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    Grant amount: \16250000 ( Direct Cost: \12500000 、 Indirect Cost: \3750000 )

    Graphene is an excellent acceptor in fluorescence resonance energy transfer (FRET) process in visible light region. Using this characteristics, we developed a biosensor (graphene FRET aptasensor) that emit fluorescence when the target protein exists in a sample. We showed that the graphene FRET aptasensor yields more than 3 times greater fluorescence than GO sensor. We designed the sensor array with internal reference for quantitative detections by combining microfluidics technology to the graphene FRET aptasensor. We showed the limit of detection of the graphene FRET aptasensor is several hundred ng/mL. For the electron transfer reaction of graphene, we built a new surface modification for a substrate to strengthen adhesion between graphene and substrate though the electrochemical properties of graphene is remained.

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Intellectual property rights

  • バイオセンサおよびバイオセンサの製造方法

    大嶋 梓,山口 真澄

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    Application no:特願2022-121437  Date applied:2022.7.29

    Announcement no:特開2024-018237  Date announced:2024.2.8

    Applicant (Organization):学校法人中央大学,日本電信電話株式会社

  • バイオセンサおよびバイオセンサの製造方法

    上野 祐子,大嶋 梓,山口 真澄

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    Application no:特願2022-121437  Date applied:2022.7.29

    Announcement no:特開2024-018237  Date announced:2024.2.8