Updated on 2023/11/01

写真a

 
UENO Yuko
 
Organization
Faculty of Science and Engineering Professor
Other responsible organization
Applied Chemistry Course of Graduate School of Science and Engineering, Master's Program
Applied Chemistry Course of Graduate School of Science and Engineering, Doctoral Program
Contact information
The inquiry by e-mail is 《here
External link

Degree

  • D. Sc. ( The University of Tokyo )

  • M. Sc. ( The University of Tokyo )

Education

  • 1997.3
     

    The University of Tokyo   School of Science   Department of Chemistry   master course   completed

  • 1995.3
     

    The University of Tokyo   School of Science   Department of Chemistry   graduated

Research History

  • 2020.4 -  

    Chuo University   "Faculty of Science and Engineering, Department of Applied Chemistry"   Professor

  • 2020.4 -  

    Chuo University   Faculty of Science and Engineering, Department of Applied Chemistry   Professor

  • 2019.7 - 2020.3

    NTT物性科学基礎研究所   グループリーダー

  • 2018.4 - 2020.3

    NTT Basic Research Laboratories   Distinguished Scientist

  • 1997.4 - 2020.3

    NTT R&D

  • 2019.4 -  

    Saitama Institute of Technology   非常勤講師

  • 2014.10 - 2019.3

    NTT物性科学基礎研究所   主幹研究員

  • 2018.6    

    Tokyo Medical and Dental University   大学院   特別講師

  • 2017.7    

    Tohoku Institute of Technology   大学院   特別講師

  • 2014.2 - 2014.9

    NTT物性科学基礎研究所   主任研究員

  • 2009.7 - 2014.1

    NTTマイクロシステムインテグレーション研究所   主任研究員

  • 2005.4 - 2009.6

    NTTマイクロシステムインテグレーション研究所   研究主任

  • 2004.10 - 2005.10

    Lawrence Berkeley National Laboratory   post-doctoral fellow

  • 2004.10 - 2005.10

    The University of California at Berkeley   post-doctoral fellow

  • 2002.7 - 2005.3

    NTTマイクロシステムインテグレーション研究所   研究員

  • 2002.10 - 2003.10

    Sophia University   理工学部   非常勤講師

  • 1999.1 - 2002.6

    NTT生活環境研究所   研究員

  • 1997.8 - 1998.12

    NTT入出力システム研究所   研究員

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Professional Memberships

  • 日本化学会

  • 日本分析化学会

  • 日本分光学会

  • 応用物理学会

  • 化学とナノ・マイクロシステム学会

  • 日本表面科学会(現:日本表面真空学会)

  • 電子情報通信学会

  • 化学センサ研究会

  • 電気化学会

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Research Interests

  • molecular structure

  • molecular spectroscopy

  • Physical chemistry

  • biosensor

  • Micro nano chemistry

  • chemical sensor

  • Analytical chemistry

Research Areas

  • Nanotechnology/Materials / Nano/micro-systems  / Nano/Microsystems

Papers

  • Redox Cycling in Microgap Monolayer Graphene Electrodes Made Without Using a Microfabrication Process Reviewed

    Satomi Onuki, Yuko Ueno

    Sensors and Materials   35 ( 10 )   4789 - 4789   2023.10

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:MYU K.K.  

    DOI: 10.18494/sam4566

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  • Electrochemical analysis of ferrocene in bicontinuous microemulsions using beta- cyclodextrin modified monolayer graphene electrodes Reviewed

    Sho Narafu, Yoshinori Takashima, Osamu Niwa, Tatsuhiko Yajima, Yuko Ueno

    JOURNAL OF ELECTROANALYTICAL CHEMISTRY   920   116575   2022.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE SA  

    A monolayer graphene electrode modified with beta-cyclodextrin (beta-CD) was produced via a one-step reaction using an originally synthesized pyrene derivative of beta-CD (py-beta-CD). A py-beta-CD-modified graphene electrode with a high modification density exceeding a coverage of 0.5 was obtained. Using this electrode, the electro-chemical behaviors of water-insoluble ferrocene (Fc) and of a water-soluble ferrocene derivative in a bicontin-uous microemulsion (BME) solution, consisting of a phosphate buffer (pH = 7.4), sodium dodecyl sulfate (SDS), 2-butanol, and toluene, were analyzed to investigate the effects of beta-CD modification on the redox reac-tions of these species. In the reduction reaction of water-insoluble Fc, almost no peak was observed for the unmodified graphene electrode, whereas a high peak current increase was observed for the beta-CD-modified elec-trode. The mechanism of the increase in the peak current of the reduction reaction can be derived from many small water domains formed around the beta-CD molecules on the graphene surface. These water domains form many oil-water interfaces on the surface of the graphene electrode, which act as an [Fc]+1 concentration field by interacting with SDS.

    DOI: 10.1016/j.jelechem.2022.116575

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  • Graphene-Based FRET Aptasensors. Invited Reviewed

    Yuko Ueno

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   37 ( 3 )   439 - 446   2021.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Graphene-based FRET aptasensors can be realized only by unique combinations of aptamer that can be freely functionalized by chemical modification, and graphene/graphene oxide that works as an excellent fluorescence acceptor at the same time as aptamer adsorbates. This review describes the principles of the sensor, several applications to microchannel devices, improvement of the sensing performance by molecular design of the aptamer and remarks on future prospects based on an introduction of recent works and achievements, including the author's paper. The sensor employs DNA modified with graphene/graphene oxide at the terminal as the molecular probe. This system is supported by the excellent property of DNA that does not lose the molecular recognition ability even due to a chemical modification at the terminal. I hope that this review will be useful for developing research on higher performance of graphene aptasensors in the future.

    DOI: 10.2116/analsci.20SCR08

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  • Tough, permeable and biocompatible microfluidic devices formed through the buckling delamination of soft hydrogel films. Reviewed International journal

    Riku Takahashi, Hiroki Miyazako, Aya Tanaka, Yuko Ueno, Masumi Yamaguchi

    Lab on a chip   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Microchannels in soft materials play an important role in developing movable, deformable, and biocompatible fluidic systems for applications in various fields. Intensively investigated approaches to create microscale channel architectures use mechanical instability in soft materials, which can provide intricate yet ordered architectures with low cost and high throughput. Here, for microchannel fabrication, we demonstrate the use of swelling-driven buckle delamination of hydrogels, which is a mechanical instability pattern found in compressed film/substrate layer composites. By spatially controlling interfacial bonding between a thin polyacrylamide (PAAm) gel film and glass substrate, swelling-driven compressive stress induces buckle delamination at programmed positions, resulting in the formation of continuous hollow paths as microchannels. Connecting flow tubes with a 3D-printed connecter provides a deformable microfluidic device, enabling pressure-driven flows without leakage from the connecter and rupture of the channels. Furthermore, by stacking less-swellable bulk gels on the device, we obtained a tough, permeable, and biocompatible microfluidic device. Finally, we performed a cell culture on the device and chemical stimulation to cells through the diffusion of molecules from the microchannels. The results of this work shed light on designing pressure sensitive/resistant microfluidic systems based on diverse hydrogels with intricate 3D morphologies and will be useful for applications in the fields of bioanalysis, biomimetics, tissue engineering, and cell biology.

    DOI: 10.1039/d0lc01275k

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  • Molecular Recognition Functional Materials and Their Application to Microanalysis Invited Reviewed

    Yuko Ueno

    BUNSEKI KAGAKU   69 ( 7-8 )   373 - 383   2020

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    Language:Japanese   Publisher:JAPAN SOC ANALYTICAL CHEMISTRY  

    Here we review our achievements on micro bio and chemical sensors that we originally developed by creating molecular recognition functional materials, and integrating them into microdevices. The first theme is a portable environmental gas sensing system that uses mesoporous silicate as a gas adsorbate having high benzene gas selectivity. For gas identification and quantitative detection, we used a spectroscopic measurement by employing a microfluidic device with optical fibers. We succeeded to detect toxic benzene gas at ppb levels in car exhausts containing interference components. The second theme is an on-chip graphene biosensor to detect biologically important proteins, such as cancer markers. Here, graphene behaves as an efficient acceptor for fluorescence resonance energy transfer (FRET) over the entire visible wavelength region. Graphene works simultaneously as a strong adsorbate for single-stranded DNAs (ssDNA), such as aptamers via a pi-pi interaction in the sp(2) domain. In our system, the graphene surface is modified with a pyrene-aptamer-dye probe. The segments work as a linker to the graphene surface, a selective protein recognition part, and a fluorescence detection tag. The system allows us to perform molecular detection on a solid surface, which constitutes a powerful tool for realizing an on-chip sensor.

    DOI: 10.2116/bunsekikagaku.69.373

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  • Dopamine detection on activated reaction field consisting of graphene-integrated silicon photonic cavity Reviewed

    Rai Kou, Yuzuki Kobayashi, Suzuyo Inoue, Tai Tsuchizawa, Yuko Ueno, Satoru Suzuki, Hiroki Hibino, Tsuyoshi Yamamoto, Hirochika Nakajima, Koji Yamada

    OPTICS EXPRESS   27 ( 22 )   32058 - 32068   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:OPTICAL SOC AMER  

    Graphene is widely recognized as an outstanding and multi-functional material in various application fields such as electronics, photonics, mechanics, and life sciences. We propose a neurotransmitter sensor with ultra-small volume for detecting the photonic light-matter response. Such detection can be achieved using surface-activated monolayer graphene sheets and CMOS-compatible silicon-photonic circuits. Patterned pieces of CVD-grown graphene are integrated on the top of a silicon micro-ring resonator, which induce the adsorption of catecholamine molecules originated from the pi-stacking effect. We used dopamine to demonstrate such detection and examine the sensitivity of graphene-dopamine coupling. To avoid high optical insertion loss and degradation of resonance characteristics caused by a graphene's extremely high optical absorption coefficient in the near infrared region, a ring resonator with adjusted coupling design is used to compensate for the drawbacks. Owing to the advanced nano-sensing platform and measurement system, an activated graphene-sensing surface of only similar to 30 mu m(2)/ch enables pi coupling to dopamine with enough sensitivity to detect less than 10-mu M solution concentration. The detection mechanism through the surface reaction is also verified by optical simulation and atomic force microscopy measurement, revealing that the flowing dopamine molecules can only occupy the outermost surface of graphene. We expect this sensor to contribute to the development of an innovative label-free and disposable bio-sensing platform with accurate, sensitive, and fast response. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

    DOI: 10.1364/OE.27.032058

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  • Dynamic Creation of 3D Hydrogel Architectures via Selective Swelling Programmed by Interfacial Bonding Reviewed

    Riku Takahashi, Hiroki Miyazako, Aya Tanaka, Yuko Ueno

    ACS Applied Materials & Interfaces   11 ( 31 )   28267 - 28277   2019.8

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acsami.9b05552

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  • Graphene-based neuron encapsulation with controlled axonal outgrowth Reviewed

    Koji Sakai, Tetsuhiko F. Teshima, Hiroshi Nakashima, Yuko Ueno

    NANOSCALE   11 ( 28 )   13249 - 13259   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ROYAL SOC CHEMISTRY  

    Neuronal constructs with tuneable 3D geometry can contribute greatly to the construction of brain-like functional tissues for transplantable grafts and robust experimental models. In this study, we propose a self-folding graphene/polymer bilayer film that forms a micro-roll for neuron encapsulation, and highlight the importance of employing pores on the micro-roll to allow neurons to interact with their surroundings. The micro-patterns and varied thicknesses of the bilayer provide control over the 3D geometries of the micro-roll. The pores facilitate the diffusion of reagents, resulting in the adequate loading of probes for imaging and the successful stimulation of the encapsulated neurons. Moreover, the encapsulated neurons inside the micro-roll are functionally integrated into surrounding neuronal networks by extending their axons through the pores. Thus, our method for encapsulating neurons with a porous graphene-laden film allows the construction of precisely shaped neuronal tissues that interact with their surroundings. We believe that the method will open a new avenue for the reconstruction of functional neuronal tissues and is potentially applicable to other self-folding bilayers.

    DOI: 10.1039/c9nr04165f

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  • Mesoporous Silica Reviewed

    Yuko Ueno

    ANALYTICAL SCIENCES   35 ( 2 )   121 - 122   2019.2

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    Language:English   Publisher:JAPAN SOC ANALYTICAL CHEMISTRY  

    DOI: 10.2116/analsci.highlights1902

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  • Self-Folded Three-Dimensional Graphene with a Tunable Shape and Conductivity Reviewed

    Tetsuhiko F. Teshima, Calum S. Henderson, Makoto Takamura, Yui Ogawa, Shengnan Wang, Yoshiaki Kashimura, Satoshi Sasaki, Toichiro Goto, Hiroshi Nakashima, Yuko Ueno

    NANO LETTERS   19 ( 1 )   461 - 470   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    Three-dimensional (3D) graphene architectures are of great interest as applications in flexible electronics and biointerfaces. In this study, we demonstrate the facile formation of predetermined 3D polymeric microstructures simply by transferring monolayer graphene. The graphene adheres to the surface of polymeric films via noncovalent pi-pi stacking bonding and induces a sloped internal strain, leading to the self-rolling of 3D microscale architectures. Micro patterns and varied thicknesses of the 2D films prior to the self-rolling allows for control over the resulting 3D geometries. The strain then present on the hexagonal unit cell of the graphene produces a nonlinear electrical conductivity across the device. The driving force behind the self-folding process arises from the reconfiguration of the molecules within the crystalline materials. We believe that this effective and versatile way of realizing a 3D graphene structure is potentially applicable to alternative 2D layered materials as well as other flexible polymeric templates.

    DOI: 10.1021/acs.nanolett.8b04279

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  • Adhesive Layer for Robust Graphene Transferred on Solid Support and Its Application to Graphene Microelectrode Manufacturing Reviewed

    Yuko Ueno, Kenji Dendo, Yukihide Homma, Kazuaki Furukawa

    SENSORS AND MATERIALS   31 ( 4 )   1157 - 1165   2019

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MYU, SCIENTIFIC PUBLISHING DIVISION  

    We describe an originally developed fabrication process of introducing an adhesive layer that fixes a graphene layer on a substrate via p-p interactions. The adhesive layer is prepared with an easy and highly reproductive wet chemical reaction that modifies the surface of the substrate before transferring the graphene layer. By using the process, we can greatly reduce the damage of the graphene layer that occurs during the manufacturing of a graphene microelectrode (GME). The process enables us to produce almost damage-free GMEs in high yield. The durability of a GME during an electrochemical measurement was also improved and the GME can be used stably even after repeating the electrochemical measurement, rinsing with water, and air drying.

    DOI: 10.18494/SAM.2019.2237

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  • Capturing the Freeze-Drying Dynamics of NaCl Nanoparticles Using THz Spectroscopy Reviewed

    Katsuhiro Ajito, Yuko Ueno, Jae-Young Kim, Takashi Sumikama

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   140 ( 42 )   13793 - 13797   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    Sodium chloride (NaCl) aqueous solution becomes NaCl hydrate, NaCl center dot 2H(2)O, at low temperature, which is different from potassium chloride and is a typical complex model for studying the freeze-drying process in foods and pharmaceuticals. Here, we detected unit-cell-sized NaCl particles in ice as precursor substances of NaCl center dot H2O during freezing of NaCl solution by using terahertz (THz) spectroscopy. In the freezing process, Na+ and Cl- ions form two types of metastable unit-cell-sized NaCl particles on the pathway to the well-known NaCl center dot H2O crystal production, which are not listed in the phase diagram of freezing of NaCl solution but have absorption peaks in THz spectra. This finding of single unit-cell-sized particles signifies the importance of studying the freeze-drying process in-depth and offers a new possibility for the development of freeze-drying technology for the manufacture of nanometer-sized particles such as ultrafine pharmaceutical powders, which more readily dissolve in water.

    DOI: 10.1021/jacs.8b07828

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  • Relaxation of Plasma Carriers in Graphene: An Approach by Frequency-Dependent Optical Conductivity Measurement Reviewed

    Wookjin Choi, Hayate Nishiyama, Yui Ogawa, Yuko Ueno, Kazuaki Furukawa, Tomohiro Takeuchi, Yusuke Tsutsui, Tsuneaki Sakurai, Shu Seki

    ADVANCED OPTICAL MATERIALS   6 ( 14 )   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-V C H VERLAG GMBH  

    The relaxation time and mobility of electrons on graphene are deduced quantitatively by complex permittivity analysis with microwave dielectric loss spectroscopy. Hexagonal graphene sheets with uniform domain sizes from 6 to 30 mu m, which target the mean free path of electrons on graphene based on the significantly longer turnover time of microwave probing at gigahertz (GHz) frequencies as compared to the relaxation time of electrons, are employed to determine the factors for carrier relaxation at the intradomain and grain boundaries. The changes in the complex permittivity by carrier injections clearly show an evidence of plasma carriers in graphene. This result validates the plasma carrier model with the restoring force in the GHz regime instead of the free carrier model, which is applied to analyze the optical conductivity over the terahertz (THz) regime. Based on Dirac massless fermions in graphene, the relaxation time of electrons is estimated to be 250-450 fs from the changes in complex permittivity, which are experimentally determined by frequency-dependent microwave conductivity measurements. The obtained relaxation time shows a positive correlation with the domain size of graphene, implying that the scattering dominantly occurs at the domain boundary.

    DOI: 10.1002/adom.201701402

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  • Fabrication of Graphene Microroll Aptasensor Reviewed

    Yuko Ueno, Tetsuhiko Teshima, Calum S. Henderson, Hiroshi Nakashima

    SENSORS AND MATERIALS   30 ( 12 )   2989 - 2998   2018

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MYU, SCIENTIFIC PUBLISHING DIVISION  

    We have successfully created a graphene microroll aptasensor (GMA) through the self-folding of bilayer thin films. The inner surface of the GMA consists of a functionalized graphene surface, which works as a fluorescence aptamer-based biosensor. This is achieved by combining previously reported two-dimensional (2D) graphene aptasensor technology, a novel self-folding process for flexible, multilayered polymeric films. The aptasensing portion is composed of a graphene surface, which is functionalized with a pyrene-aptamer-dye probe. The three components of the probe work as linkers to the graphene surface, a protein recognition part, and a fluorescence detection tag, respectively. In this paper, we discuss the specialized fabrication process required to produce the GMA. By confirming the diffusion of target molecules through the hollow space of the GMA, we also show the ability of this device to detect concentration changes in real time.

    DOI: 10.18494/SAM.2018.2069

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  • Cell Assembly in Self-foldable Multilayered Soft Micro-rolls Reviewed

    Tetsuhiko F. Teshima, Hiroshi Nakashima, Yuko Ueno, Satoshi Sasaki, Calum S. Henderson, Shingo Tsukada

    SCIENTIFIC REPORTS   7 ( 1 )   17376   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    Multi-layered thin films with heterogeneous mechanical properties can be spontaneously transformed to realise various three-dimensional (3D) geometries. Here, we describe micro-patterned all-polymer films called micro-rolls that we use for encapsulating, manipulating, and observing adherent cells in vitro. The micro-rolls are formed of twin-layered films consisting of two polymers with different levels of mechanical stiffness; therefore they can be fabricated by using the strain engineering and a self-folding rolling process. By controlling the strain of the films geometrically, we can achieve 3D tubular architectures with controllable diameters. Integration with a batch release of sacrificial hydrogel layers provides a high yield and the biocompatibility of the micro-rolls with any length in the release process without cytotoxicity. Thus, the multiple cells can be wrapped in individual micro-rolls and artificially reconstructed into hollow or fibre-shaped cellular 3D constructs that possess the intrinsic morphologies and functions of living tissues. This system can potentially provide 3D bio-interfaces such as those needed for reconstruction and assembly of functional tissues and implantable tissue grafts.

    DOI: 10.1038/s41598-017-17403-0

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  • Self-propelled ion gel at air-water interface Reviewed

    Kazuaki Furukawa, Tetsuhiko Teshima, Yuko Ueno

    SCIENTIFIC REPORTS   7 ( 1 )   9323   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    We report on a self-propelled gel using ionic liquid as a new type of self-propellant that generates a powerful and durable motion at an air-water interface. The gel is composed of 1-ethyl-3-methylimidazolium-bis(trifluoromethylsulfonyl)imide (EMIM-TFSI) and poly(vinylidene fluoride-co-hexafluoropropylene) (P(VDF-co-HFP)). A long rectangular ion gel piece placed on the interface shows rapid rotation motion with maximum frequency close to 10 Hz, corresponding to the velocity over 300 mms(-1) at an outmost end of the piece. The rotation continues for ca. 10(2) s, followed by a reciprocating motion (<similar to 10(3) s) and a nonlinear motion in long-time observations (>similar to 10(3) s). The behaviours can be explained by the model considering elution of EMIM-TFSI to the air-water interface, rapid dissolution into water, and slow diffusion in an inhomogeneous polymer gel network. Because the self-propellants are promptly removed from the interface by dissolution, durable self-propelled motions are observed also at limited interface areas close in size to the gel pieces. A variety of motions are induced in such systems where the degree of freedom in motion is limited. As the ion gel possesses formability and processability, it is also advantageous for practical applications. We demonstrate that the gel does work as an engine.

    DOI: 10.1038/s41598-017-09351-6

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  • Raman Spectroscopy of Pharmaceutical Cocrystals in Nanosized Pores of Mesoporous Silica Reviewed

    Ryuichi Ohta, Yuko Ueno, Katsuhiro Ajito

    ANALYTICAL SCIENCES   33 ( 1 )   47 - 52   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC ANALYTICAL CHEMISTRY  

    The Raman spectroscopy of pharmaceutical cocrystals based on caffeine and oxalic acid in nanosized pores of mesoporous silica has been demonstrated at various molar amounts. The Raman peak shifts of caffeine molecules express the existence of pharmaceutical cocrystals in mesoporous silica. The molar amount dependence of the peak shifts describes that caffeine and oxalic acid cocrystallized on the surface of the nanosized pores and piled up layer by layer. This is the first report that shows the Raman spectroscopy is a powerful tool to observe the synthesis of pharmaceutical cocrystals incorporated in the nanosized pores of mesoporous silica. The results indicate a way to control the size of cocrystals on a nanometer scale, which will provide higher bioavailability of pharmaceuticals.

    DOI: 10.2116/analsci.33.47

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  • Graphene FRET Aptasensor Reviewed

    Kazuaki Furukawa, Yuko Ueno, Makoto Takamura, Hiroki Hibino

    ACS SENSORS   1 ( 6 )   710 - 716   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    We report on a new protein sensor built on pristine graphene. Graphene grown by chemical vapor deposition and supported on a SiO2 surface was modified with a sequence consisting of pyrene, DNA aptamer, and dye. Here, an aptamer is a nucleic acid having a specific base sequence that recognizes and forms a complex with a target molecule such as a protein. In our protein sensing system, the recognition of a target protein triggers the fluorescence of a dye tethered on the graphene surface. This is based on the effective fluorescence quenching property of graphene via fluorescence resonance energy transfer (FRET). We first demonstrate that the graphene FRET aptasensor yields fluorescence when there is a target protein in the sample using prostate specific antigen (PSA, a cancer marker) as the target. We confirm that the fluorescence intensities vary depending on the PSA concentrations. We also discuss the selectivity and limit of detection using a microchannel configuration built on a graphene FRET aptasensor. A similar aptasensor has been intensively studied using graphene oxide (GO) dispersed in aqueous media, but has been little studied on a solid support. By preparing the graphene and GO FRET aptasensor on the same substrate, we show quantitatively that the graphene sensor yields brighter fluorescence than the GO aptasensor. We also demonstrate the response of the graphene FRET aptasensor under sample flow conditions.

    DOI: 10.1021/acssensors.6b00191

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  • Control of surface wettability of hydroxyapatite thin films by way of crystal imperfections Reviewed

    Housei Akazawa, Yuko Ueno

    APPLIED PHYSICS EXPRESS   8 ( 10 )   2015.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOP PUBLISHING LTD  

    The wettability of hydroxyapatite (HAp) films can be controlled by process conditions and substrates. C-plane-terminated HAp films on Si(100) substrate were hydrophobic. Only when sputter deposition with Ar was carried out with H2O vapor, followed by solid-phase crystallization at 500-700 degrees C, did highly hydrophilic films with water contact angles between 10 and 20 degrees form. The hydrophilic property was characterized by H2O bending mode signals at 1595 cm(-1) in infrared spectroscopy. Preferentially c- or (310)-plane-oriented epitaxial HAp films on sapphire c-planes were hydrophobic, whereas randomly oriented polycrystalline HAp films on sapphire a-planes were moderately hydrophilic. (C) 2015 The Japan Society of Applied Physics

    DOI: 10.7567/APEX.8.107001

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  • On-chip FRET Graphene Oxide Aptasensor: Quantitative Evaluation of Enhanced Sensitivity by Aptamer with a Double-stranded DNA Spacer Reviewed

    Yuko Ueno, Kazuaki Furukawa, Andrew Tin, Hiroki Hibino

    ANALYTICAL SCIENCES   31 ( 9 )   875 - 879   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC ANALYTICAL CHEMISTRY  

    We propose a molecular design for a biomolecular probe to realize an on-chip graphene oxide (GO) aptasensor with enhanced sensitivity. Here, GO works as an excellent acceptor for fluorescence resonance energy transfer. We inserted a rigid double-stranded DNA as a spacer between the GO surface and the aptamer sequence to extend the distance between a fluorescence dye and the GO surface during molecular recognition. We examined the dependence of the sensitivity on the length of the spacer quantitatively by using a 2x2 linear-array aptasensor. We used the modified aptamer with 10 and 30 base pair (bp) double-stranded DNA spacers. The signal with a 30bp-spacer was about twice as strong that with a 10bp-spacer as regards both thrombin and prostate specific antigen detections. The improvement in the sensitivity was supported by a model calculation that estimated the effect of spacer length on fluorescence recovery efficiency.

    DOI: 10.2116/analsci.31.875

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  • Low-temperature crystallization and high-temperature instability of hydroxyapatite thin films deposited on Ru, Ti, and Pt metal substrates Reviewed

    Housei Akazawa, Yuko Ueno

    SURFACE & COATINGS TECHNOLOGY   266   42 - 48   2015.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE SA  

    We investigated the crystallinity, orientation, and stability of hydroxyapatite (HAp) thin films on structural materials including SiO2 and metals (Ru, Ti, and Pt). The HAp films were deposited by electron cyclotron resonance (ECR) plasma sputtering with an Xe sputtering gas under simultaneous flow of H2O vapor. The HAp films as-crystallized during deposition and solid-phase crystallized by post annealing were analyzed with X-ray diffraction, Fourier-transform infrared spectroscopy, and Raman scattering. The lowest solid-phase crystallization temperatures were 350 degrees C on Ru, 300 degrees C on Ti, and 300 degrees C on Pt. These crystallization temperatures are much lower than those on silicon and SiO2 substrates (550 degrees C). For HAp films as-crystallized at temperatures above 400 degrees C, the elements out diffused and reacted with substrates. Precipitation of CaO was observed for HAp films deposited on SiO2 and Ru substrates. Diffusion of POET into SiO2 and Ru-catalyzed decomposition of HAp crystals are suggested for the mechanism. When deposited on Pt substrates, CaPt2O4 alloy byproducts were created for solid-phase crystallized films and CaPt2 alloy byproducts were created for as-crystallized films, indicating reaction of Ca atoms with Pt substrates. (C) 2015 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.surfcoat.2015.02.011

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  • On-chip graphene oxide aptasensor for multiple protein detection Reviewed

    Yuko Ueno, Kazuaki Furukawa, Kota Matsuo, Suzuyo Inoue, Katsuyoshi Hayashi, Hiroki Hibino

    ANALYTICA CHIMICA ACTA   866   1 - 9   2015.3

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    The versatility of an on-chip graphene oxide (GO) aptasensor was successfully confirmed by the detection of three different proteins, namely, thrombin (TB), prostate specific antigen (PSA), and hemagglutinin (HA), simply by changing the aptamers but with the sensor composition remaining the same. The results indicate that both DNA and RNA aptamers immobilized on the GO surface are sufficiently active to realize an on-chip aptasensor. Molecular selectivity and concentration dependence were investigated in relation to TB and PSA detection by using a dual, triple, and quintuple microchannel configuration. The multiple target detection of TB and PSA on a single chip was also demonstrated by using a 2 x 3 linear-array GO aptasensor. This work enables us to apply this sensor to the development of a multicomponent analysis system for a wide variety of targets by choosing appropriate aptamers. (C) 2014 Elsevier B.V. All rights reserved.

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  • Terahertz chemical spectroscopy Invited Reviewed

    Yuko Ueno, Katsuhiro Ajito

    Handbook of Terahertz Technologies: Devices and Applications   429 - 450   2015.1

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  • Distinct crystallinity and orientations of hydroxyapatite thin films deposited on C- and A-plane sapphire substrates Reviewed

    Housei Akazawa, Yuko Ueno

    JOURNAL OF CRYSTAL GROWTH   404   241 - 245   2014.10

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    We report how the crystallinity and orientation of hydroxyapatite (HAp) films deposited on sapphire substrates depend on the crystallographic planes. Both solid-phase crystallization of amorphous HAp Films and crystallization during sputter deposition at elevated temperatures were examined. The low-temperature epitaxial phase on C-plane sapphire substrates has c-axis orientated HAp crystals regardless of the crystallization route, whereas the preferred orientation switches to the (310) direction at higher temperatures. Only the symmetric stretching mode (v(1)) of PO43- units appears in the Raman scattering spectra, confirming well-ordered crystalline domains. In contrast, HAp crystals grown on A-plane sapphire substrates are always oriented toward random orientations. Exhibiting all vibrational modes (v(1), v(3), and v(4)) of PO43- units in the Raman scattering spectra reflects random orientation, violating the Raman selection rule. If we assume that Raman intensities of PO43- units represent the crystallinity of HAp films, crystallization terminating the surface with the C-plane is hindered by the presence of excess H2O and OH species in the film, whereas crystallization at random orientations on the A-plane sapphire is rather promoted by these species. Such contrasting behaviors between C-plane and A-plane substrates will reflect surface-plane dependent creation of crystalline seeds and eventually determine the orientation of resulting HAp films. (C) 2014 Elsevier B.V. All rights reserved.

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  • Quantitative Mapping of Pharmaceutical Cocrystals Within Cellulose by Terahertz Spectroscopy Reviewed

    Jae-Young Kim, Resza Boenawan, Yuko Ueno, Katsuhiro Ajito

    JOURNAL OF LIGHTWAVE TECHNOLOGY   32 ( 20 )   3768 - 3773   2014.10

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    Terahertz (THz) spectroscopy is a powerful tool for identifying inter-molecular hydrogen bonds in pharmaceutical materials. Here, we present quantitative chemical imaging of multicomponent pellets composed of pharmaceutical cocrystals and cellulose by THz spectroscopy. The stabilized THz time-domain spectroscope with laser beam monitoring and feedback supports accurate absorption spectra measurement. The linearity of THz absorptions of cocrystals and cellulose against the concentration are experimentally verified. In addition, the concentrations of the materials inside pellets are quantitatively extracted and mapped from the THz spectroscopic image by linear regression using reference THz spectra obtained for cocrystals and diluents.

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  • Air-band optical resonators in one-dimensional Si photonic crystal waveguides for biosensing applications Reviewed

    Kakuro Hirai, Takahiro Araki, Jingnan Cai, Katsuyoshi Hayashi, Tsutomu Horiuchi, Yuzuru Iwasaki, Yuko Ueno, Emi Tamechika, Kazumi Wada, Yasuhiko Ishikawa

    JAPANESE JOURNAL OF APPLIED PHYSICS   53 ( 4 )   2014.4

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    Optical cavities using air-band states in Si photonic crystals (PhCs) are proposed as biosensors. Since the light in the air band of PhCs is preferably located at the lower-index cladding rather than the inside of higher-index Si, interactions are enhanced between the light and the target molecules in the cladding, being effective for the sensitive detections. Such an air-band PhC is used as an optical cavity, which is surrounded with another PhC as the photonic-bandgap mirrors. Simulations are performed for air-band resonators in one-dimensional (1D) PhC of arrayed holes in a Si channel waveguide, in order to analyze a figure of sensing, i.e., red shifts in the resonance wavelengths induced by the presence of target molecules. The S value, the amount of red shift caused by the unit change in the cladding index, can be as large as 200 nm/RIU, which is 2 times larger than those for ordinary 1D-PhC resonators. Fabricated devices successfully show the resonance peaks, whose wavelengths and quality factors agree well with theoretical ones. These results suggest that the air-band resonators are promising for high-performance biosensors. (C) 2014 The Japan Society of Applied Physics

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  • 新分野事業の開拓に貢献する先端デバイス・材料技術 テラヘルツ分光による医薬結晶の識別技術 Invited Reviewed

    味戸克裕, キム ジェヨン, 上野祐子, ソン ホジン

    NTT技術ジャーナル   26 ( 2 )   23 - 26   2014.2

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  • Control of composition and crystallinity in hydroxyapatite films deposited by electron cyclotron resonance plasma sputtering Reviewed

    Housei Akazawa, Yuko Ueno

    JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS   75 ( 1 )   94 - 99   2014.1

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    Hydroxyapatite (HAp) films were deposited by electron cyclotron resonance plasma sputtering under a simultaneous flow of H2O vapor gas. Crystallization during sputter-deposition at elevated temperatures and solid-phase crystallization of amorphous films were compared in terms of film properties. When HAp films were deposited with Ar sputtering gas at temperatures above 460 degrees C, CaO byproducts precipitated with HAp crystallites. Using Xe instead of Ar resolved the compositional problem, yielding a single HAp phase. Preferentially c-axis-oriented HAp films were obtained at substrate temperatures between 460 and 500 degrees C and H2O pressures higher than 1 x 10(-2) Pa. The absorption signal of the asymmetric stretching mode of the PO43- unit (nu(3)) in the Fourier-transform infrared absorption (FT-IR) spectra was the narrowest for films as-crystallized during deposition with Xe, but widest for solid-phase crystallized films. While the symmetric stretching mode of PO43- (nu(1)) is theoretically IR-inactive, this signal emerged in the FT-IR spectra of solid-phase crystallized films, but was absent for as-crystallized films, indicating superior crystallinity for the latter. The Raman scattering signal corresponding to nu(1) PO43- sensitively reflected this crystallinity. The surface hardness of as-crystallized films evaluated by a pencil hardness test was higher than that of solid-phase crystallized films. (C) 2013 Elsevier Ltd. All rights reserved.

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  • Nondestructive Multicomponent Terahertz Chemical Imaging of Medicine in Tablets Reviewed

    Katsuhiro Ajito, Jae-Young Kim, Yuko Ueno, Ho-Jin Song, Keisuke Ueda, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe

    JOURNAL OF THE ELECTROCHEMICAL SOCIETY   161 ( 9 )   B171 - B175   2014

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    Molecular networks based on noncovalent bonds have resonant frequencies in the terahertz (THz) region. THz spectroscopy is a powerful tool for identifying molecular bonds, such as intermolecular or intramolecular hydrogen bonds, in pharmaceuticals. A THz chemical imaging (TCI) system was developed by combining a THz time-domain spectrometer with a translational stage to obtain two-dimensional distributions of molecular networks in tablet samples Since THz spectral peaks of pharmaceuticals are broad at room temperature, multicomponent chemical analysis with the TCI system has some limitations. In this paper, we describe multicomponent,chemical analysis of pharmaceuticals using a sample chamber cooled, by a cryostat. TCI measurement at low temperature sharpens spectral peaks and/or shifts peak frequencies, enabling us to determine the distribution of several kinds of pharmaceuticals in a tablet. The TCI system provides THz images of polymorphic form distribution of famotidine binding with D-mannitol in an over-the-counter pharmaceutical tablet. Furthermore, the molecular mechanics method was used to determine the vibrational modes of the peaks in the spectra of famotidine polymorphic forms. (C) The Author(s) 2014. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited. All rights reserved.

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  • Nondestructive three-dimensional observation of the influence of zirconium inclusions in laser-irradiated fusion-spliced optical fiber on core structure changes using synchrotron radiation X-ray micro-computed tomography Reviewed

    Shinji Koike, Shuichi Yanagi, Yuko Ueno, Kenya Suzuki, Tetsuo Takahashi, Kentaro Uesugi, Akihisa Takeuchi, Masato Hoshino, Yoshio Suzuki, Yoshio Watanabe

    Japanese Journal of Applied Physics   52 ( 9 )   2013.9

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    In this paper, we describe a nondestructive method of observing changes in the microstructure of optical fibers subjected to CO2 laser irradiation for optical fiber splicing using synchrotron radiation micro-computed tomography (CT). In particular, we evaluated a method of enhancing the contrast between a GeO2-doped optical fiber core and a silica cladding by performing CT observations of the X-ray energy around the Ge-K absorption edge. Specifically, procedures for extracting a GeO2-doped core from a three-dimensional image of optical fibers by the cluster labeling method are proposed and evaluated. The approach enabled us to observe how inclusions at the optical fiber splicing interface influence the optical fiber core structure. We also expect this observation method to be used for improving such aspects of laser processing performance as insertion loss and mechanical strength for recently developed optical fibers. © 2013 The Japan Society of Applied Physics.

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  • Growth of preferentially c-axis oriented hydroxyapatite thin films on Si(100) substrate by electron-cyclotron-resonance plasma sputtering Reviewed

    Housei Akazawa, Yuko Ueno

    APPLIED SURFACE SCIENCE   276   217 - 222   2013.7

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    We deposited hydroxyapatite (HAp) thin films on Si(1 0 0) substrates by means of electron cyclotron resonance (ECR) plasma sputtering from a HAp target and characterized their structural properties by X-ray diffraction (XRD) and Fourier transform infrared absorption spectroscopy. Deposition in the presence of an H2O vapor at room temperature incorporated H2O and OH species in the deposited films. Post-annealing in an O-2 ambient self-organized OH- and PO43- functional groups in HAp crystals. The XRD patterns revealed randomly orientation when the annealing temperature ranged between 700 and 900 degrees C. In contrast, preferentially c-axis-oriented HAp crystals nucleated after prolonged annealing at 550-600 degrees C. The possible scenario for the preferred orientation is that C-plane terminated HAp crystallites were initially created in the near-surface region, and the following crystallization proceeded exclusively on the seed surface. After post annealing in a vacuum or in an Ar gas ambient at 900 degrees C, films were reduced into tricalcium phosphate, increasing photoabsorption in the infrared range. (c) 2013 Elsevier B.V. All rights reserved.

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  • Chemical Mapping of Pharmaceutical Cocrystals Using Terahertz Spectroscopic Imaging Reviewed

    Danielle M. Charron, Katsuhiro Ajito, Jae-Young Kim, Yuko Ueno

    ANALYTICAL CHEMISTRY   85 ( 4 )   1980 - 1984   2013.2

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    Terahertz (THz) spectroscopic imaging is a promising technique for distinguishing pharmaceuticals of similar molecular composition but differing crystal structures. Physicochemical properties, for instance bioavailability, are manipulated by altering a drug's crystal structure through methods such as cocrystallization. Cocrystals are molecular complexes having crystal structures different from those of their pure components. A technique for identifying the two-dimensional distribution of these alternate forms is required. Here we present the first demonstration of THz spectroscopic imaging of cocrystals. THz spectra of caffeine-oxalic acid cocrystal measured at low temperature exhibit sharp peaks, enabling us to visualize the cocrystal distribution in nonuniform tablets. The cocrystal distribution was clearly identified using THz spectroscopic data, and the cocrystal concentration was calculated with 0.3-1.3% w/w error from the known total concentration. From this result, THz spectroscopy quantitative chemical mapping of cocrystals and offers researchers and drug developers a new analytical tool.

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  • Graphene-modified Interdigitated Array Electrode: Fabrication, Characterization, and Electrochemical Immunoassay Application Reviewed

    Yuko Ueno, Kazuaki Furukawa, Katsuyoshi Hayashi, Makoto Takamura, Hiroki Hibino, Emi Tamechika

    ANALYTICAL SCIENCES   29 ( 1 )   55 - 60   2013.1

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    We have developed a new procedure for fabricating interdigitated array gold electrodes (Au-IDA) modified with reduced graphene oxide (rGO). In this procedure, we coated the gold surface of the micrometer order electrodes with graphene oxide (GO) prior to the reduction and the lift-off processes to avoid short-circuiting the pair of electrodes by conductive rGO flakes after the reduction. We then studied the basic electrochemical activity of the prepared electrodes, rGO/Au-IDA, mainly on p-aminophenol (pAP), because pAP is a good probe for an electrochemical immunoassay. The voltammograms showed that denser rGO provides better electrode reactivity for pAP. We confirmed that redox cycling between the anode and cathode at the rGO/Au-IDA was established, which yields more sensitive detection than with a single electrode. As one application of the electrochemical immunoassay using the rGO/Au-IDA, we demonstrated the quantitative detection of cortisol, a stress marker, at levels found in human saliva.

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  • Effects of Sensing Layer Thickness on Biosensing Using Partially-Slotted Si Photonic Crystal Waveguides Reviewed

    Takahiro Araki, Kakuro Hirai, Jingnan Cai, Yasuhiko Ishikawa, Kazumi Wada, Katsuyoshi Hayashi, Tsutomu Horiuchi, Yuzuru Iwasaki, Yuko Ueno, Emi Tamechika

    2013 CONFERENCE ON LASERS AND ELECTRO-OPTICS PACIFIC RIM (CLEO-PR)   2013

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    One-dimensional Si photonic crystal waveguides having a partial slot resonator are investigated for biosensing. The thickness of sensing layer for antigen-antibody reactions is found to be one of the critical parameters for the high sensitivity.

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  • Biosensing on a Graphene Oxide Surface Invited Reviewed

    Kazuaki Furukawa, Yuko Ueno

    NTT Technical Review   11   1 - 5   2013

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  • Protein recognition on a single graphene oxide surface fixed on a solid support Reviewed

    Kazuaki Furukawa, Yuko Ueno, Emi Tamechika, Hiroki Hibino

    JOURNAL OF MATERIALS CHEMISTRY B   1 ( 8 )   1119 - 1124   2013

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    We study protein recognition on a graphene oxide (GO) surface using a single GO piece fixed on a solid support. The GO surface is modified by newly designed processes using pyrene as a linker to an sp(2) domain in the GO, an aptamer for thrombin recognition, and a probe dye for fluorescence detection. In this system, the dye probe fluorescence, which was initially quenched by GO, is recovered when the aptamer recognizes the corresponding protein. We demonstrate the label-free and selective protein recognition for thrombin. The elementary processes of protein recognition are observed directly with a confocal laser scanning microscope and an atomic force microscope using an identical piece of GO. They indicate that proteins are recognized homogeneously on the modified GO surface. We also show that the recognition system can be installed and operated in microchannel devices.

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  • Molecular design for enhanced sensitivity of a FRET aptasensor built on the graphene oxide surface Reviewed

    Yuko Ueno, Kazuaki Furukawa, Kota Matsuo, Suzuyo Inoue, Katsuyoshi Hayashi, Hiroki Hibino

    CHEMICAL COMMUNICATIONS   49 ( 88 )   10346 - 10348   2013

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    We designed a biomolecular probe for highly sensitive protein detection by modifying an aptamer with a DNA spacer. The spacer controls the distance between a fluorescence dye and a quencher, which is crucial for FRET-based sensors. We successfully demonstrated an improvement in the sensitivity of an on-chip graphene oxide aptasensor.

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  • Isothermic determination of aqueous solution glucose concentration in low mg/dL range by CW-photoacoustic-based protocol Reviewed

    S. Camou, Y. Ueno, E. Tamechika

    Sensors and Actuators, B: Chemical   185   568 - 574   2013

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    In order to decrease the impact of diabetes mellitus on patient quality of life, noninvasive and continuous monitoring of blood glucose level represents the ideal detection protocol for an appropriate decision-making process. The limit of detection of such a sensor should be lower than 70 mg/dL for efficient detection of hypoglycemia episodes. However, a reasonable anticipation of loss of accuracy when moving from in vitro to in vivo requires demonstration of sensitivity several times lower than this value in the ideal in vitro conditions for any viable alternative to the standard finger-prick-based method. This paper then investigates the detection of aqueous glucose solutions at low concentration levels based on a measurement protocol called "frequency shift" (FS). This protocol, based on the continuous-wave photoacoustic technique, is equivalent to an acoustic velocity measurement and therefore depends on the temperature as well. A thermo-regulated bath system was then used to control the temperature with an accuracy of ±0.035 C. The sensor showed a linear glucose dependence characterized by a slope of 0.19%/g/dL, which is consistent with previously reported results, and accuracy of about ±26 mg/dL was obtained. Using a differential experimental protocol, we were able to improve the temperature control accuracy down to ±0.015 C. Measurements down to a 9.6 mg/dL concentration level were demonstrated with an accuracy of ±3.5 mg/dL despite a bias from temperature fluctuations equivalent to a ±11 mg/dL glucose concentration variation. The FS protocol then enables low milligram per deciliter glucose concentration measurements at levels several times lower than the requirements. However, temperature variations strongly limit the measurement accuracy due to the lack of FS selectivity to glucose. To take full advantage of the proposed approach, temperature should then be monitored simultaneously and its effect compensated to allow comparable sensitivity in in vivo conditions. © 2013 Elsevier B.V.

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  • Terahertz Chemical Imaging and Spectroscopy of Molecular Networks in Pharmaceutical and Biomedical Applications Reviewed

    Ajito Katsuhiro, Ueno Yuko, Song Ho-Jin, Tamechika Emi, Kukutsu Naoya, Limwikrant Waree, Yamamoto Keiji, Moribe Kunikazu

    Meeting Abstracts   ( 56 )   3844   2012

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  • Terahertz Chemical Imaging of a Multicomponent Tablet in Pharmaceutical Applications Reviewed

    Katsuhiro Ajito, Yuko Ueno, Ho-Jin Song, Jae-Young Kim, Emi Tamechika, Naoya Kukutsu, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe

    CHEMICAL SENSORS 10 -AND- MEMS/NEMS 10   50 ( 12 )   109 - 116   2012

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    Molecular networks based on hydrogen bonds have resonant frequencies in the terahertz (THz) region. THz spectroscopy is a powerful tool for identifying molecular networks created by intermolecular or intra-molecular hydrogen bonds in pharmaceutical and biomedical samples such as drugs, proteins, and cancer cells. A THz chemical imaging (TCI) system was developed by combining a THz time-domain spectrometer with a translational stage to obtain two-dimensional distributions of molecular networks in tablet samples. Since THz spectral peaks of pharmaceuticals are broad at room temperature, multicomponent chemical analysis is limited using the TCI system. In this paper, we describe multicomponent chemical analysis of pharmaceuticals using a sample chamber cooled by a cryostat. TCI measurement at low temperature sharpens spectral peaks and/or shifts peak frequencies, enabling us to determine the distribution of several kinds of pharmaceutical chemicals within a tablet.

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  • Terahertz chemical imaging of a multicomponent tablet in pharmaceutical applications Reviewed

    Katsuhiro Ajito, Yuko Ueno, Ho-Jin Song, Jae-Young Kim, Emi Tamechika, Naoya Kukutsu, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe

    ECS Transactions   50 ( 12 )   109 - 116   2012

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    Molecular networks based on hydrogen bonds have resonant frequencies in the terahertz (THz) region. THz spectroscopy is a powerful tool for identifying molecular networks created by intermolecular or intra-molecular hydrogen bonds in pharmaceutical and biomedical samples such as drugs, proteins, and cancer cells. A THz chemical imaging (TCI) system was developed by combining a THz time-domain spectrometer with a translational stage to obtain two-dimensional distributions of molecular networks in tablet samples. Since THz spectral peaks of pharmaceuticals are broad at room temperature, multicomponent chemical analysis is limited using the TCI system. In this paper, we describe multicomponent chemical analysis of pharmaceuticals using a sample chamber cooled by a cryostat. TCI measurement at low temperature sharpens spectral peaks and/or shifts peak frequencies, enabling us to determine the distribution of several kinds of pharmaceutical chemicals within a tablet. © 2012 The Electrochemical Society.

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  • THz Chemical Imaging for Biological Applications Reviewed

    Katsuhiro Ajito, Yuko Ueno

    IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY   1 ( 1 )   293 - 300   2011.9

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    THz spectroscopy is advantageous in analytical chemistry because it can detect and identify intermolecular interactions in chemical compounds, such as hydrogen bonds and hydrations, and molecular networks. Recent advances in THz components, such as ultrashort pulsed lasers and photoconductive antennas, have improved the sensitivity of THz time-domain (TDS) spectroscopy and have made the THz chemical imaging possible. THz chemical imaging can reveal hydrogen bond distributions and will be a very powerful tool in biology, pharmacology, and life sciences. THz-TDS is also promising for the quantitative chemical analysis and detection of molecules and clusters in nanospace and ice.

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  • Quantitative Analysis of Amino Acids in Dietary Supplements Using Terahertz Time-domain Spectroscopy Reviewed

    Yuko Ueno, Katsuhiro Ajito, Naoya Kukutsu, Emi Tamechika

    ANALYTICAL SCIENCES   27 ( 4 )   351 - 356   2011.4

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    We successfully analyzed the concentrations of five amino acids in commercially available dietary amino acid supplements by using terahertz time-domain spectroscopy (THz-TDS) with an error of +/- 12% for the best reproduced components. We also succeeded in analyzing tablets of the supplements wrapped in paper, and thus showed the merit of using THz waves for the nondestructive quantitative analysis of packaged samples by employing the fact that THz waves are capable of passing through several types of packaging material. The ability of THz waves to pass through the paper made it possible to perform a quantitative analysis using the same standard spectra as those used for an unwrapped sample, and the accuracy of a direct quantitative analysis of a packaged sample was almost the same as that of an unwrapped sample.

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  • Terahertz chemical imaging of molecular networks for pharmaceutical applications Reviewed

    Ajito Katsuhiro, Ueno Yuko, Song Ho-Jin, Tamechika Emi, Kukutsu Naoya

    ECS Transactions   35 ( 7 )   157 - 165   2011

  • Terahertz Spectroscopic Imaging of Polymorphic Forms in Pharmaceutical Crystals Reviewed

    Katsuhiro Ajito, Yuko Ueno, Ho-Jin Song, Emi Tamechika, Naoya Kukutsu

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS   538 ( 1 )   33 - 38   2011

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    A terahertz spectroscopic imaging system was fabricated for the detection of two-dimensional molecular distributions in pharmaceutical tablets based on absorption peaks of intermolecular or intramolecular hydrogen bonds in crystals. The terahertz imaging system consists of a terahertz time-domain spectrometer and a three-dimension translational stage. Using the system, we obtained frequency-dependent terahertz images of famotidine polymorphic forms A and B. An offset subtraction process is useful for detecting the distribution in an inhomogeneous tablet containing a mixture of the two forms. The terahertz imaging technique is a valuable tool for the analysis of polymorphic forms of crystal in inhomogeneous pharmaceutical tablets.

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  • Analytical Terahertz Chemical Imaging of Molecular Networks in Bio-Medical Applications Reviewed

    Ajito Katsuhiro, Ueno Yuko, Song Ho-Jin, Tamechika Emi, Kukutsu Naoya

    Meeting Abstracts   ( 17 )   1185   2011

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  • Near-Infrared Photoluminescence Spectral Imaging of Chemically Oxidized Graphene Flakes Reviewed

    Yuko Ueno, Emi Tamechika, Kazuaki Furukawa, Satoru Suzuki, Hiroki Hibino

    e-J. Surf. Sci. Nanotech.   10   513 - 517   2011

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    In order to determine the local structure of carbon sp(2) clusters in chemically modified graphene oxide (GO) flakes, their luminescence was analyzed, using near- infrared photoluminescence (NIR PL) spectral imaging. GO flakes emit a broad PL spectrum of wavelengths of 800 to 1400 nm, indicating that they contain sp(2) clusters, whose size is theoretically estimated to be in the 1.3 to 2.3 nm region. The size distribution of such sp(2) clusters is fairly uniform at different positions and for different numbers of layers of GO, at the spatial resolution of NIR PL image (5 mu m). The analysis by transmission electron microscopy directly confirmed the existence of such sp(2) clusters and the estimated size of the sp(2) clusters was widely ranged from 0.5 to 4 nm. The effect of the GO reduction to the local structure of carbon sp(2) clusters was also studied and it was found that the NIR PL intensity decreased as the reduction progressed and that there was no large spectral shift.

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  • Terahertz Chemical Imaging of Molecular Networks for Pharmaceutical Applications Reviewed

    Katsuhiro Ajito, Yuko Ueno, Ho-Jin Song, Emi Tamechika, Naoya Kukutsu

    BIOELECTRONICS, BIOINTERFACES, AND BIOMEDICAL APPLICATIONS 4   35 ( 7 )   157 - 165   2011

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    A terahertz (THz) chemical imaging system was fabricated for the detection of two-dimensional molecular networks in pharmaceutical tablets. Frequency-dependent THz images of homemade tablets containing polymorphic forms enables us to determine the distribution of two polymorphic forms. The system also provided THz images of polymorphic form distribution of famotidine in an over-the-counter drug tablet for the first time. Furthermore, the molecular mechanics method was used to determine the vibrational modes of famotidine polymorphic forms.

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  • Chirality emergence in thin solid films of amino acids by polarized light from synchrotron radiation and free electron laser Reviewed

    Jun-Ichi Takahashi, Hiroyuki Shinojima, Michiko Seyama, Yuko Ueno, Takeo Kaneko, Kensei Kobayashi, Hajime Mita, Mashahiro Adachi, Masahito Hosaka, Masahiro Katoh

    International Journal of Molecular Sciences   10 ( 7 )   3044 - 3064   2009.7

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    One of the most attractive hypothesis for the origin of homochirality in terrestrial bioorganic compounds is that a kind of "chiral impulse" as an asymmetric excitation source induced asymmetric reactions on the surfaces of such materials such as meteorites or interstellar dusts prior to the existence of terrestrial life (Cosmic Scenario). To experimentally introduce chiral structure into racemic films of amino acids (alanine, phenylalanine, isovaline, etc.), we irradiated them with linearly polarized light (LPL) from synchrotron radiation and circularly polarized light (CPL) from a free electron laser. After the irradiation, we evaluated optical anisotropy by measuring the circular dichroism (CD) spectra and verified that new Cotton peaks appeared at almost the same peak position as those of the corresponding non-racemic amino acid films. With LPL irradiation, twodimensional anisotropic structure expressed as linear dichroism and/or linear birefringence was introduced into the racemic films. With CPL irradiation, the signs of the Cotton peaks exhibit symmetrical structure corresponding to the direction of CPL rotation. This indicates that some kinds of chiral structure were introduced into the racemic film. The CD spectra after CPL irradiation suggest the chiral structure should be derived from not only preferential photolysis but also from photolysis-induced molecular structural change. These results suggest that circularly polarized light sources in space could be associated with the origin of terrestrial homochirality
    that is, they would be effective asymmetric exciting sources introducing chiral structures into bio-organic molecules or complex organic compounds. © 2009 by the authors
    licensee Molecular Diversity Preservation International.

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  • Terahertz Spectroscopy for Nanostructured Materials Invited Reviewed

    AJITO Katsuhiro, UENO Yuko, HAGA Tsuneyuki, KUKUTSU Naoya

    Ceramics Japan   44 ( 3 )   172 - 176   2009.3

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  • Dynamic range criterion of THz spectrum for amino acids measurements Reviewed

    Zhaohui Zhang, Zuxing Zhang, Yixin Yin, Yuko Ueno, Rakchanok Rungsawang, Katsuhiro Ajito

    Frontiers of Optoelectronics in China   2 ( 3 )   239 - 243   2009

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    Terahertz (THz) absorption spectra have been applied to measure the compositions of amino acid samples. Because the concentration information about a specific composition is involved in its spectrum, keeping the spectrum length and dynamic range as wide as possible is essential for precise measurements. It is well known that a spectrum is always contaminated by apparatus noises. In this paper, we present a criterion for noise cutting based on wavelet transform, which usually extends the range determined by traditional threshold criterion. Finally, the improvement on measurement precision shows the validity of the new criterion. © 2009 Higher Education Press and Springer-Verlag GmbH.

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  • Molecular Recognition of Low Molecular Weight Organic Compounds in Mesoporous Silica and Their Applications to Microscale Analytical System Invited Reviewed

    Yuko Ueno

    BUNSEKI KAGAKU   57 ( 11 )   871 - 881   2008.11

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    We developed a molecular-recognition material of low-molecular-weight organic Compounds by using mesoporous silicas, and applied this material to a chemical sensor, aiming at the development of new and practical analytical techniques. We have found that it is important to determine the optimized surface condition and the porosity of mesoporous silicas to compare very similar molecules, namely benzene and toluene, which have no and one methyl group, respectively, in their Molecular structures. We applied mesoporous silica to a micro gas-sensing system, which has been originally developed. We Succeeded to detect benzene gas at ppm levels in car exhausts containing interference components. We also found that mesoporpos silica is an excellent optical material in the terahertz region, and we developed a useful way for terahertz time-domain spectroscopy to distinguish between intra- and intermolecular modes by incorporating target molecules in nano-sized spaces of nanoporous materials.

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  • Terahertz images of biological molecules: Frequency dependence of spatial resolution using a tunable terahertz laser source Reviewed

    Yuko Ueno, Rakchanok Rungsawang, Isao Tomita, Katsuhiro Ajito

    JAPANESE JOURNAL OF APPLIED PHYSICS   47 ( 2 )   1315 - 1320   2008.2

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    The spatial resolution of transmitted terahertz (THz) images of metal slits and protein [myoglobin (Mb)] thin films was analyzed at 1.40, 1.63, and 2.55THz by using continuous THz waves from a tunable gas laser. The resolution of the THz images of the metal slit was 0.40, 0.35, and 0.45mm at 2.55, 1.63, and 1.40THz, respectively. The spatial resolution is determined not only by the diffraction limit of the wavelength of the THz wave but also by other experimental conditions such as laser power. The resolution of the THz images of Mb thin films was 0.55 and 0.60 mm at 2.55 and 1.63 THz, respectively. The approximately twofold stronger THz wave absorption of Mb film at 2.55 THz than at 1.63 THz provides the better resolution. By using a THz wave with a frequency at which the target sample has strong absorption we can obtain a THz image with good resolution.

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  • Analytical terahertz spectroscopy Invited Reviewed

    Yuko Ueno, Katsuhiro Ajito

    ANALYTICAL SCIENCES   24 ( 2 )   185 - 192   2008.2

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    Recent progress in analytical terahertz (THz) spectroscopy is reviewed with illustrative examples showing that it is an effective method for detecting and identifying intermolecular interactions in chemical compounds, such as hydrogen bonds. The unique and characteristic properties of THz waves, their significance to both science and industry, and the bases of one of the successful fields of analytical THz spectroscopy, namely THz time-domain spectroscopy and THz imaging for chemical analysis, are described. Preliminary quantitative studies are presented to show the potential of THz spectroscopy for the detection and identification of intermolecular hydrogen bonds in unknown mixture samples. The selective detection of intramolecular hydrogen bonds and the detection of intramolecular interactions in ice are also introduced. Some brief remarks are provided on future developments, the main issues, and the prospects for analytical THz spectroscopy.

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  • Terahertz images of biological molecules: Frequency dependence of spatial resolution using a tunable terahertz laser source Reviewed

    Ueno Yuko, Rungsawang Rakchanok, Tomita Isao, Ajito Katsuhiro

    Japanese Journal of Applied Physics   47 ( 2S )   1315   2008

  • テラヘルツ領域の分光技術の最前線と分析化学 テラヘルツ時間領域分光法による生体関連の有機酸結晶の化学分析 Invited Reviewed

    上野祐子, 味戸克裕

    ぶんせき   2007 ( 11 )   583 - 585   2007.11

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  • Detecting a sodium chloride ion pair in ice using terahertz time-domain spectroscopy Reviewed

    Rakchanok Rungsawang, Yuko Ueno, Katsuhiro Ajito

    ANALYTICAL SCIENCES   23 ( 7 )   917 - 920   2007.7

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    The hydrogen bond resonance of a sodium chloride (NaCl) ion pair trapped in aqueous ice has been observed by transmission terahertz time-domain spectroscopy. The absorption peak of a sodium chloride ion pair in ice is 1.65 THz at 83 K. By investigating the interaction of the cation and anion with other chemical compounds, we deduce that the absorption peak originates from the hydrogen bond resonance of sodium chloride and water molecules. The charge redistribution that occurs when other ion pairs are added to aqueous salt solution changes the absorption spectrum. Furthermore, the results also indicate that simple molecules such as sodium halides have fingerprints in the terahertz region when the ions are trapped in ice. NaCl ion pairs in seawater and in Ringer's solution were examined.

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  • Terahertz time-domain spectra of aromatic carboxylic acids incorporated in nano-sized pores of mesoporous silicate Reviewed

    Yuko Ueno, Katsuhiro Ajito

    ANALYTICAL SCIENCES   23 ( 7 )   803 - 807   2007.7

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    Terahertz time-domain spectroscopy (THz-TDS) is used to study the intra- and intermolecular vibrational modes of aromatic carboxylic acids, for example, o-phthalic acid, benzoic acid, and salicylic acid, which form either intra- or intermolecular hydrogen bond(s) in different ways. Incorporating the target molecules in nano-sized spaces in mesoporous silicate (SBA-16) is found to be effective for the separate detection of intramolecular hydrogen bonding modes and intermolecular modes. The results are supported by an analysis of the differences in the peak shifts, which depend on temperature, caused by the different nature of the THz absorption. Raman spectra revealed that incorporating the molecules in the nano-sized pores of SBA-16 slightly changes the molecular structures. In the future, THz-TDS using nanoporous materials will be used to analyze the intra- and intermolecular vibrational modes of molecules with larger hydrogen bonding networks such as proteins or DNA.

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  • Analysis of power enhancement of terahertz waves in periodically inverted GaP pumped at 1.55 mu m Reviewed

    I. Tomita, H. Suzuki, R. Rungsawang, Y. Ueno, K. Ajito

    PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE   204 ( 4 )   1221 - 1226   2007.4

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    We have generated terahertz (THz) waves by difference frequency generation (DFG) with a 1.55 mu m pump laser. 1.55 mu m pump beams were effectively converted to 1 THz waves through a periodically chi((2))- inverted GaP stack fabricated by direct wafer bonding. The output efficiency was an order of magnitude larger than that of typical chi ((2)) materials such as lithium niobate employing a similar DFG method. To investigate the increase in output power due to quasi-phase matching including optical losses, we measured its dependence on stack length. From the measured data, we analyze the conditions for effective power enhancement and show that it takes place if the pump-beam loss, alpha, is much smaller than that of the THz waves, alpha (3) (or the pump-beam attenuation length, 1/alpha, is much longer than that of the THz waves, 1/alpha(3),), which is achieved by improving the bonding quality of the stack. (c) 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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  • Analysis of power enhancement of terahertz waves in periodically inverted GaP pumped at 1.55 μm Reviewed

    I. Tomita, H. Suzuki, R. Rungsawang, Y. Ueno, K. Ajito

    Physica Status Solidi (A) Applications and Materials Science   204 ( 4 )   1221 - 1226   2007.4

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    We have generated terahertz (THz) waves by difference frequency generation (DFG) with a 1.55 μm pump laser. 1.55 μm pump beams were effectively converted to 1 THz waves through a periodically χ (2)-inverted GaP stack fabricated by direct wafer bonding. The output efficiency was an order of magnitude larger than that of typical χ (2) materials such as lithium niobate employing a similar DFG method. To investigate the increase in output power due to quasi-phase matching including optical losses, we measured its dependence on stack length. From the measured data, we analyze the conditions for effective power enhancement and show that it takes place if the pump-beam loss, α, is much smaller than that of the THz waves, α 3 (or the pump-beam attenuation length, 1/αa, is much longer than that of the THz waves, 1/α 3), which is achieved by improving the bonding quality of the stack. © 2007 WILEY-VCH Verlag GmbH &amp
    Co. KGaA.

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  • ナノ構造材料を用いたテラヘルツ時間領域分光法 Invited Reviewed

    上野祐子, 味戸克裕

    分光研究   56 ( 1 )   15 - 16   2007.2

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  • Quantitative analyses of amino acids based on terahertz absorption spectra Reviewed

    Zhang Zhaohui, Lv Luodong, Yin Yixin, Ueno Yuko, Rungsawang Rakchanok, Ajito Katsuhiro

    Journal of Analytical Science   23 ( 6 )   651   2007

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  • Terahertz time-domain spectra of inter- and intramolecular hydrogen bonds of fumaric and maleic acids Reviewed

    Yuko Ueno, Rakchanok Rungsawang, Isao Tomita, Katsuhiro Ajito

    CHEMISTRY LETTERS   35 ( 10 )   1128 - 1129   2006.10

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    The inter- and intramolecular hydrogen-bonding modes of two steric isomers, namely fumaric acid and maleic acid, are observed by using terahertz time-domain spectroscopy (THz-TDS). The intermolecular modes observed with fumaric acid crystals are inactivated by incorporating the molecules in the nano-sized pores of a mesoporous silicate (SBA-16) due to the separation of the molecules, whereas the intramolecular modes of maleic acid of the crystal and the incorporated samples are similar.

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  • Angle-dependent terahertz time-domain spectroscopy of amino acid single crystals Reviewed

    Rakchanok Rungsawang, Yuko Ueno, Isao Tomita, Katsuhiro Ajito

    JOURNAL OF PHYSICAL CHEMISTRY B   110 ( 42 )   21259 - 21263   2006.10

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    The measurement of absorption spectra using angle-dependent terahertz (THz) time-domain spectroscopy for amino acid single crystals of L-cysteine and L-histidine is reported for the first time. Linearly polarized THz radiation enables us to observe angle-dependent far-infrared absorption spectra of amino acid single crystals and determine the direction of the oscillating dipole of the molecules in the 20-100 cm(-1) range. By comparing the THz spectra of a single crystal and powder, we found that there was a clear hydrogen-bond peak in the crystal spectrum as a result of the larger hydrogen-bond network. The low-temperature THz spectra of amino acid microcrystals showed more intermolecular vibrational modes than those measured at room temperature. An ab initio frequency calculation of a single amino acid molecule was used to predict the intramolecular vibrational modes. The validity of the calculation models was confirmed by comparing the results with experimentally obtained data in the Raman spectral region.

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  • Prognostic significance of p53 mutation in suboptimally resected advanced ovarian carcinoma treated with the combination chemotherapy of paclitaxel and carboplatin Reviewed

    Yuko Ueno, Takayuki Enomoto, Yoshiro Otsuki, Nagatoshi Sugita, Ryuichi Nakashima, Kiyoshi Yoshino, Chie Kuragaki, Yutaka Ueda, Tadaatsu Aki, Hiromasa Ikegami, Masato Yamazaki, Kimihiko Ito, Masaaki Nagamatsu, Takamichi Nishizaki, Masahiro Asada, Takashi Kameda, Akinori Wakimoto, Takahiro Mizutani, Takako Yamada, Yuji Murata

    CANCER LETTERS   241 ( 2 )   289 - 300   2006.9

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    The prognostic significance of p53 mutation, microsattelite instability and DNA mismatch protein hMLH1 expression in suboptimally resected advanced ovarian carcinoma treated with the combination chemotherapy of paclitaxel and carboplatin was evaluated. The overall combination chemotherapy response rate and the complete remission rate were significantly higher among patients with mutant p53 tumors than those with wild-type p53 tumors (35/42 (83%) vs. 32/58 (55%); P=0.003 and 18/42 (43%) vs. 16/58 (28%); P=0.03, respectively). This tendency apparently existed in non-serous carcinoma, but not in serous carcinoma. Univariate analysis showed that the risk of death due to disease and risk of progression was significantly lower among patients with p53 mutation (P=0.0357 and 0.0281, respectively). However, the presence of microsattelite instability or loss of hMLH1 expression was not associated with either the clinical response or prognosis. Determining p53 mutational status can be useful in predicting therapeutic response to drugs in ovarian carcinoma, especially in non-serous tumors. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

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  • ANYL 107-Study of intra- and intermolecular hydrogen bond systems by terahertz time-domain spectroscopy Reviewed

    Yuko Ueno, Rachanok Rungsawang, Isao Tomita, Katsuhiro Ajito

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   232   2006.9

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  • Spontaneous rupture of uterine surface varicose veins in pregnancy: A case report Reviewed

    Kazumasa Hashimoto, Chisa Tabata, Yuko Ueno, Hirotsugu Fukuda, Koichiro Shimoya, Yuji Murata

    JOURNAL OF REPRODUCTIVE MEDICINE   51 ( 9 )   722 - 724   2006.9

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    BACKGROUND: Spontaneous rupture of uterine surface varicose veins is rare but may become a serious complication of pregnancy.
    CASE: A 40-year-old woman, gravida 2, para 0-0-1-0, presented with worsening generalized abdominal pain after occasional nausea, vomiting and diarrhea over the previous 2 days. After a 4-hour observation period, sudden onset of severe, prolonged fetal heart rate decelerations was recognized along with frequent uterine contractions. Emergency cesarean section was performed under a tentative diagnosis of placental abruption. A live, female infant weighing 1,730 g was delivered and had Apgar scores of 5 and 9 at 1 and 5 minutes, respectively. Intraoperatively, approximately 500 mL of hemoperitoneum was present, and multiple bleeding sites from varicose veins on the posterior uterine surface were detected. Because the maternal vital signs became unstable and hemostasis was difficult, hysterectomy was performed and blood transfusion administered.
    CONCLUSION: Although very rare, hemoperitoneum should be included in the differential diagnosis when a pregnant woman experiences acute-onset, severe abdominal pain, even without an episode of abdominal trauma.

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  • Infrared spectroscopic investigation of higher diamondoids Reviewed

    Jos Oomens, Nick Polfer, Olivier Pirali, Yuko Ueno, Roha Maboudian, Paul W. May, Jacob Filik, Jeremy E. Dahl, Shenggao Liu, Robert M. K. Carlson

    JOURNAL OF MOLECULAR SPECTROSCOPY   238 ( 2 )   158 - 167   2006.8

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    Attenuated total reflection Fourier transform infrared spectra are recorded for a number of diamond molecules (or higher diamondoids) in the spectral range between 650 and 3000 cm(-1). Molecules studied are diamantane, triamantane, [121]tetramantane, [123]tetramantane, [1(2,3)4]pentamantane, [12(3)4]pentamantane, 3-methyl-[1(2,3)4]pentamantane, and [12312]hexamantane (cyclohexamantane). Spectral trends are clearly recognized throughout the spectra revealing the general fingerprint of this class of molecules. In general, the spectra show good agreement with density functional theory calculations at the B3LYP/D95(d,p) level of theory. (c) 2006 Elsevier Inc. All rights reserved.

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  • Quantitative measurements of amino acids by terahertz time-domain transmission spectroscopy Reviewed

    Yuko Ueno, Rakchanok Rungsawang, Isao Tomita, Katsuhiro Ajito

    ANALYTICAL CHEMISTRY   78 ( 15 )   5424 - 5428   2006.8

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    The quantitative analysis of amino acids by terahertz (THz) time-domain absorption spectroscopy is demonstrated. The optical densities of the amino acids were found to be linearly proportional to the concentration. The molar absorption coefficients of L-glutamic acid (L-Glu), L-glutamic acid sodium salt ( Na- L-Glu), L- glutamic acid hydrochloric salt (HCl-L-Glu), L- cysteine (L-Cys), and L- histidine ( L- His) were calculated by averaging the THz spectra of the amino acids at several different concentrations in approximately the 0.2-1.0 mol L-1 range. The concentrations of L-Glu, L-Cys, and L- His mixed samples were successfully calculated with errors of less than 11% and 20% when their concentrations were higher than 0.45 and 0.22 mol L-1, respectively, by using the obtained molar absorption coefficient.

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  • テラヘルツ分光を用いた化学センシング Invited Reviewed

    味戸克裕, 富田勲, RUNGSAWANG Rakchanok, 上野祐子

    電気化学および工業物理化学   74 ( 6 )   506 - 511   2006.6

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    DOI: 10.5796/electrochemistry.74.506

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  • Terahertz notch filter using intermolecular hydrogen bonds in a sucrose crystal Reviewed

    Rakchanok Rungsawang, Yuko Ueno, Isao Tomita, Katsuhiro Ajito

    OPTICS EXPRESS   14 ( 12 )   5765 - 5772   2006.6

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    We propose a THz notch filter that uses the absorption of the intermolecular hydrogen bonds in a molecular crystal such as sucrose. Terahertz ( THz) time-domain spectroscopy was used to investigate the absorption characteristics of a rotationally oriented sucrose single crystal in the 0.3-3.0 THz frequency range. The crystal was set so that the ( 100) face ( cleavage) was normal to the THz propagation direction. The two lowest frequency intermolecular hydrogen bonding bands clearly exist at room temperature and at 1.45 and 1.64 THz when the b-axis of the crystal is parallel and perpendicular to the THz polarization, respectively. In contrast, they disappear when the b-axis is reversed. This absorption feature means that it would be possible to utilize a sucrose crystal as a notch filter with a 1.45-THz band center for the 0.1-1.7 THz range and with a 1.64-THz band center for the 0.1-1.9 THz range. When the crystal is rotated, the transmitted intensities of the frequency components near the absorption bands alternate as a sine function against angle. The spectroscopic properties of the sucrose filter were confirmed by continuous THz wave imaging. (c) 2006 Optical Society of America.

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  • Terahertz-wave generation from quasi-phase-matched GaP for 1.55 mu m pumping Reviewed

    Tomita, I, H Suzuki, H Ito, H Takenouchi, K Ajito, R Rungsawang, Y Ueno

    APPLIED PHYSICS LETTERS   88 ( 7 )   071118 - 071118   2006.2

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    We have realized a terahertz (THz)-wave source employing difference frequency generation (DFG) from a quasi-phase-matched GaP stack pumped at 1.55 mu m. We observed THz waves with enhanced power by quasi-phase matching (QPM) in the < 110 > direction of GaP with a < 111 > polarization direction for the incidence of two pump lights with the same propagation and polarization directions. We obtained THz-wave power proportional to the product of two pump-light powers due to DFG. We also confirmed that power peaks appeared at around 1 and 2.6 THz reflecting the first- and the third-order QPM, respectively.

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  • Widely tunable terahertz-wave generation by collinearly phase-matched difference-frequency generation from GaP Reviewed

    I. Tomita, R. Rungsawang, Y. Ueno, K. Ajito

    CONFERENCE DIGEST OF THE 2006 JOINT 31ST INTERNATIONAL CONFERENCE ON INFRARED AND MILLIMETER WAVES AND 14TH INTERNATIONAL CONFERENCE ON TERAHERTZ ELECTRONICS   117 - 117   2006

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    We propose a novel method to realize widely tunable terahertz-wave generation from GaP by collinearly phase-matched difference-frequency generation. Our method makes it possible to achieve a wavelength-tunable output without decreasing the output efficiency, which can be used for wavelength sweeping in spectroscopy.

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  • High benzene selectivity of mesoporous silicate for BTX gas sensing microfluidic devices Reviewed

    Yuko Ueno, Akiyuki Tate, Osamu Niwa, Hao Shen Zhou, Takeo Yamada, Itaru Honma

    Analytical and Bioanalytical Chemistry   382 ( 3 )   804 - 809   2005.6

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    The gas selectivities of highly ordered mesoporous silicates and commercially-obtained porous silicates with respect to benzene, toluene and xylene were studied. After studying the porosities, pore uniformities, and surface silanol structures of the silicates and their relationships to gas selectivity in detail, we found that we could achieve high benzene selectivity by controlling the micropore size (less than 1 nm). Concluding that mesoporous silicate has a suitable micropore size and structure for benzene selectivity, we also observed that mesoporous silicate SBA-16 exhibited a high (>6) benzene selectivity from toluene and xylene even in a pseudo-atmospheric environment. A benzene detection limit of about 100 ppb was achieved by introducing SBA-16 into a microfluidic device originally developed for the separate detection of benzene, toluene, and xylene gases. © Springer-Verlag 2005.

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  • A simple method for fabrication of mesoporous films using a rapid heating process Reviewed

    Takeo Yamada, Haoshen Zhou, Itaru Honma, Yuko Ueno, Tsutomu Horiuchi, Osamu Niwa

    Chemistry Letters   34 ( 3 )   328 - 329   2005.3

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    Mesoporous silica SBA-15 and SBA-16 films can be successfully prepared on a substrate by a simple method involving a rapid heating process, which is controlled by a voltage applied to a heating electrode on the substrate. This advantageous method has considerable potential for electronic device fabrication processes. Copyright © 2005 The Chemical Society of Japan.

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  • Effect of the calcination temperature of self-ordered mesoporous silicate on its adsorption characteristics for aromatic hydrocarbons Reviewed

    Yuko Ueno, Tsutomu Horiuchi, Akiyuki Tate, Osamu Niwa, Hao Shen Zhou, Takeo Yamada, Itaru Honma

    New Journal of Chemistry   29 ( 3 )   504 - 508   2005.3

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    We have studied the changes in the adsorption characteristics of mesoporous silicate (SBA-15) for benzene and toluene that are caused by using different calcination temperatures (Tc = 773 to 1173 K) in the synthesis process. We found that SBA-15 calcined at 773 K shows an extremely high benzene selectivity, especially in the low pressure region, while SBA-15 treated at higher Tc shows lower selectivity. In order to analyze the benzene selective mechanism, we studied the structures of the SBA-15 series, including their meso- and microporosity in detail. We found that the BET surface area (SBET) and the peak position of the mesopore diameter (2R p) decreased, the peak position of the micropore diameter (2r p) increased, and the 2rp distribution became broader with increasing Tc. Among above factors, we conclude that the size and the distribution of 2rp are the most important to achieve a high benzene selectivity. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2005.

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  • Combined terahertz spectral imaging and NIR Raman microscopy for the analysis of chromoprotein and chromophore films Reviewed

    K Ajito, R Rungsawang, Y Ueno, Tomita, I, H Takenouchi

    IRMMW-THz2005: The Joint 30th International Conference on Infrared and Millimeter Waves and 13th International Conference on Terahertz Electronics, Vols 1 and 2   211 - 212   2005

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    A tunable frequency terahertz; (THz) wave source provides spectral images of chromoprotein and chromophore films on quartz plates. A Near-infrared (NIR) Raman microprobe mapping technique is used to measure the same regions in the films in order to detect the molecular structure and to understand THz spectral images. The fact that there is little fluorescence interference in NIR Raman microscopy for the colour films is an advantage over visible Raman microscopy. A combination of THz spectral imaging and NIR Raman microscopy techniques enables us to observe the distribution of molecules and to expand the field of THz imaging research.

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  • Real-time spectral imaging of protein films using a tunable TRz laser source Reviewed

    R Rungsawang, Y Ueno, H Takenouchi, Tomita, I, K Ajito

    IRMMW-THz2005: The Joint 30th International Conference on Infrared and Millimeter Waves and 13th International Conference on Terahertz Electronics, Vols 1 and 2   481 - 482   2005

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    The absorption spectrum of a protein, namely horse heart myoglobin, was measured by terahertz time-domain spectroscopy of up to 2.75 THz. High-power THz radiation from a tunable cw gas-vapour laser was used to perform two-dimensional imaging. Clear images of the protein film were obtained by monitoring it at the absorption peak frequency. Experimental results show that a spectral image of biological samples can be obtained by employing THz radiation in real time.

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  • Terahertz-wave generation from periodically-inverted GaP pumped at 1.55 mu m Reviewed

    Tomita, I, H Takenouchi, H Suzuki, K Ajito, R Rungsawang, Y Ueno, H Ito

    2005 IEEE LEOS Annual Meeting Conference Proceedings (LEOS)   238 - 239   2005

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    DOI: 10.1109/LEOS.2005.1547967

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  • Absorption detection on glass microchip with reflective layer coating for portable BTX measurements Reviewed

    S Camou, Y Ueno, A Tate, O Niwa

    Micro Total Analysis Systems 2004, Vol 2   ( 297 )   455 - 457   2005

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    In order to improve the sensitivity of portable air monitoring system based on absorption microdetection cell, we proposed different fabrication processes and tested its regarding the optical guidance efficiency. Two materials (Aluminum and Titanium / Platinum) have been coated on the microchannels sidewalls as reflective layers. Due to its better reflective properties in UV range, Aluminum yields to improvement by a factor of 2 in terms of coupling efficiency through a 3 cm long optical cell, while the gain is around 30% with Titanium/Platinum.

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  • Characterization of carbon nanotubes suspended between nanostructures using micro-Raman spectroscopy

    Kobayashi, Y, Takagi, D, Ueno, Y, Homma, Y

    PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES   24 ( 1-2 )   26 - 31   2004.8

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    DOI: 10.1016/j.physe.2004.04.018

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  • Vibrational spectra and electron-vibration interactions of the naphthalene radical anion - Experimental and theoretical study Reviewed

    Hajime Torii, Yuko Ueno, Akira Sakamoto, Mitsuo Tasumi

    Canadian Journal of Chemistry   82 ( 6 )   951 - 963   2004.6

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    Vibrational analysis is carried out for the radical anions of naphthalene-h8 and -d8. Their infrared (IR) spectra are observed in tetrahydrofuran by using a cell designed for IR measurements of unstable species. The vibrational force field and the IR intensities are calculated by the ab initio molecular orbital and density functional methods at various theoretical levels. As found in the cases of the radical cations of many polycyclic aromatic hydrocarbons (PAHs), a few strong IR bands with intensities of the order of 102 km mol-1 are observed in the 1700-900 cm -1 region. These observed spectral features are well reproduced by the calculations at the CASSCF (complete active space self-consistent field) and B3LYP (Becke's three-parameter hybrid method using the Lee-Yang-Parr correlation functional) levels. The calculation at the B3LYP level gives a better fit between the observed and calculated absolute IR intensities. Normal modes and the origin of the strong IR intensities characteristic of the radical anions are discussed in terms of molecular symmetry coordinates and the dipole derivatives based on these coordinates. It is found that the IR intensities of the b2u modes below 2000 cm-1 are dominated by the contribution from one molecular symmetry coordinate, in which the C-C bonds in one ring stretch while those in the other ring shrink. The mechanism that gives rise to the strong IR intensity for this vibration is discussed by examining the changes in the electronic structure induced by this vibration.

    DOI: 10.1139/v04-050

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  • Extremely intense Raman signals from single-walled carbon nanotubes suspended between Si nanopillars Reviewed

    Yoshihiro Kobayashi, Takayuki Yamashita, Yuko Ueno, Osamu Niwa, Yoshikazu Homma, Toshio Ogino

    Chemical Physics Letters   386 ( 1-3 )   153 - 157   2004.3

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    Single-wall carbon nanotubes (SWNTs) suspended between ultra-fine Si nanopillars were characterized by microscopic Raman spectroscopy. The Raman signals from the suspended SWNTs are extremely intense, compared with those from the carbon nanotubes that grow on the flat surface of substrates and adhere tightly to the substrate surfaces. This intensity enhancement makes it possible to discriminate the Raman signals of the suspended SWNTs from these of carbon nanotubes on the substrate surface and thereby detect the signals from the suspended SWNTs selectively. Based on this novel phenomenon, the structural features of the suspended SWNTs are analyzed. © 2004 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.cplett.2004.01.054

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  • High benzene selectivity of uniform sub-nanometre pores of self-ordered mesoporous silicate Reviewed

    Yuko Ueno, Akiyuki Tate, Osamu Niwa, Hao Shen Zhou, Takeo Yamada, Itaru Honma

    Chemical Communications   4 ( 6 )   746 - 747   2004

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    The high benzene gas selectivity of mesoporous silicate (SBA-15) was observed in the sub-nanometre micropore condensation region. The benzene/toluene ratios of the adsorbed amount were >100 and >6 in ideal and pseudo-atmospheric environments, respectively. © 2004 The Royal Society of Chemistry.

    DOI: 10.1039/b316799b

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  • Portable automatic BTX measurement system with microfluidic device using mesoporous silicate adsorbent with nano-sized pores Reviewed

    Yuko Ueno, Tsutomu Horiuchi, Osamu Niwa, Hao Shen Zhou, Takeo Yamada, Itaru Honma

    Sensors and Actuators, B: Chemical   95 ( 1-3 )   282 - 286   2003.10

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    We have developed a portable automatic measurement system for the detection and identification of aromatic volatile organic compound (VOC) gases, namely benzene, toluene, and xylenes (BTX), which are air pollutants, by assembling two microfluidic devices, a concentration cell and a detection cell, and peripheral devices. We combined the processes of gas concentration and thermal desorption performed by the concentration cell, with the process of spectroscopic detection performed by the detection cell. We achieved a 50ppb detection limit for toluene gas as an example of BTX detection in a sampling time of 30min. We also found that we could obtain better BTX separation by using a highly ordered mesoporous silicate as a gas adsorbent due to a function of its nano-sized pores. As a result, we successfully measured ppm level concentrations of BTX in a mixture gas separately with this device. © 2003 Elsevier B.V. All rights reserved.

    DOI: 10.1016/S0925-4005(03)00540-9

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  • 大気環境モニタリング用小型VOC検出装置の開発

    堀内 勉, 上野 祐子, 丹羽 修

    電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society   123 ( 4 )   134 - 135   2003.4

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    Airborne benzene, toluene, and xylene (BTX) are aromatic volatile organic compounds (VOCs) of great social and environmental significance. Since they are toxic even at ppb concentrations and their levels of toxicity are different, quantitative identification of VOCs in the air is required. We developed small (37cm x 28 cm x 10cm) VOC detection system (fig.1) comprising microfluidic device (concentration and detection cells, 1 cm x 3 cm, respectively), a pump, a deuterium (D2) lamp, an UV spectrometer, and a SCSI interface. When BTX mixture gas was introduced into this detector, we successfully obtained the component ratios.

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  • Platinum surface modification of SBA-15 by γ-radiation treatment Reviewed

    Takeo Yamada, Hao-Shen Zhou, Daisuke Hiroishi, Masato Tomita, Yuko Ueno, Keisuke Asai, Itaru Honma

    Advanced Materials   15 ( 6 )   511 - 513   2003.3

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    Mesoporous materials are a focus of research due to their porous structure and high surface area. These innovative mesoporous materials has uniform pore size and periodic porous structural properties while retaining their basic mesoporous characteristics. This paper reports on the platinum surface modification of SBA-15, that is, the growth of platinum exclusively in the micropores on a mesoporous surface by means of radiation treatment.

    DOI: 10.1002/adma.200390118

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  • Surface Photo Voltage (SPV) Type NO, NO2 Gas Sensor Fabricated by Mesoporous Materials with Uniform Pore Size and Ordered Pore Structure Reviewed

    Takeo Yamada, Hao-Shen Zhou, Itaru Honma, Masato Tomita, Yuko Ueno, Hidekazu Uchida, Teruaki Katsube

    IEEJ Transactions on Sensors and Micromachines   123 ( 4 )   118 - 123   2003

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    The mesoporous materials SBA-15 and SBA-16 from the self-assembled template organic framework inorganic compound materials are successfully prepared with powder and film states. The powder state of mesoporous material exhibit a variety of properties and possibilities of these kinds of materials. The film state of these SBA-15 and SBA-16 are successfully fabricated into the surface photo voltage (SPV) type gas sensor device as a gas adsorption insulator layer. These kinds of gas sensors device exhibit NO and NO2 gas sensing properties dependent on their mesoporous film structure. We are succeeded in indication about a possibility of mesoporous silicate film for the SPV type gas sensor application. Keywords: mesoporous silicate, SBA-15, SBA-16, NO, NO2, gas sensor, Surface Photo Voltage. © 2003, The Institute of Electrical Engineers of Japan. All rights reserved.

    DOI: 10.1541/ieejsmas.123.118

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  • Improvement of On-Site Microfluidic Benzene, Toluene, Xylene (BTX) Gas Sensor Loaded with Nanostructured Mesoporous Silicate Reviewed

    Yuko Ueno, Tsutomu Horiuchi, Osamu Niwa, Hao Shen Zhou, Takeo Yamada, Itaru Honma

    Sensors and Materials   15 ( 8 )   393 - 402   2003

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    We have developed a gas sensing microfluidic device for the detection and identification of aromatic volatile organic compound (VOC) gases, namely, benzene, toluene, and xylenes (BTX), which are air pollutants. We combined a nanostructured material, mesoporous silicate, as a gas concentrator and separator, and carried out spectroscopic measurement with a microfluidic device for gas identification and quantitative detection. Our method is completely different from conventional methods such as gas chromatography (GC)/mass spectrometry(MS) and provides a portable, highly sensitive and selective gas monitoring system. In this paper, we report an improvement in the performance of our BTX gas sensor that we realized by optimizing the operating conditions and by using the properties of mesoporous silicate with uniform nanosized pores. We also successfully measured mixture BTX gases separately with this device. We were able to realise better BTX separation with mesoporous silicate than with random-structured silicates. We successfully analyzed the principle behind the improvement in the gas separation owing to the characteristics of the nanosized pores of mesoporous silicate by positron annihilation spectroscopy.

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  • Development of Small Size Detector for Environmental Monitoring of VOC Reviewed

    Tsutomu Horiuchi, Yuko Ueno, Osamu Niwa

    IEEJ Transactions on Sensors and Micromachines   123 ( 4 )   134 - 135   2003

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    Airborne benzene, toluene, and xylene (BTX) are aromatic volatile organic compounds (VOCs) of great social and environmental significance. Since they are toxic even at ppb concentrations and their levels of toxicity are different, quantitative identification of VOCs in the air is required. We developed small (37cm x 28 cm x 10cm) VOC detection system (fig.1) comprising microfluidic device (concentration and detection cells, 1 cm x 3 cm, respectively), a pump, a deuterium (D2) lamp, an UV spectrometer, and a SCSI interface. When BTX mixture gas was introduced into this detector, we successfully obtained the component ratios. © 2003, The Institute of Electrical Engineers of Japan. All rights reserved.

    DOI: 10.1541/ieejsmas.123.134

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  • A possibility of block-copolymer templated mesoporous silica films applied to surface photo voltage (SPV) type NO<inf>x</inf> gas sensor

    T. Yamada, H. S. Zhou, H. Uchida, M. Tomita, Y. Ueno, T. Katsube, I. Honma

    Studies in Surface Science and Catalysis   146   783 - 786   2003

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    A self-ordered hexagonal and cubic-like mesoporous silica film has been successfully fabricated from a Metal-Insulator-Semiconductor device applied to a Nitrogen oxides (NOx) gas sensor based on the surface photo voltage system. These self-ordered mesoporous silica films are synthesized by using a nonionic triblock copolymer surfactant as a template in spin coating. The sensing characteristics as a NOx gas sensor are dependent on both mesostructures and exposure gases. © 2003 Elsevier Science B. V. All rights reserved.

    DOI: 10.1016/S0167-2991(03)80500-1

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  • Co-sputtered thin film consisting of platinum nanoparticles embedded in graphite-like carbon and its high electrocatalytic properties for electroanalysis Reviewed

    Tianyan You, Osamu Niwa, Tsutomu Horiuchi, Masato Tomita, Yuzuru Iwasaki, Yuko Ueno, Shigeru Hirono

    Chemistry of Materials   14 ( 11 )   4796 - 4799   2002.11

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    The radio frequency (RF) sputtering method was used to prepare nanoscale platinum (0) particles highly dispersed in a graphite-like carbon film (Pt-NEGCF) by co-sputtering platinum and carbon. The preparation is very simple, controllable, and reproducible. We studied this film with respect to its structural characterization and electrocatalytic properties. The XPS spectrum reveals that the platinum state in the Pt-NEGCF is platinum (0). TEM images show that the structure of the carbon in the film is graphite-like and that the platinum particles are highly dispersed in the carbon matrix. The electrochemical properties of the Pt-NEGCF electrode were evaluated. Compared with Pt bulk electrode, this film electrode is highly electrocatalytic as regards hydrogen evolution, dioxygen reduction, and hydrogen peroxide oxidation with good stability.

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  • Separate detection of BTX mixture gas by a microfluidic device using a function of nanosized pores of mesoporous silica adsorbent Reviewed

    Yuko Ueno, Tsutomu Horiuchi, Masato Tomita, Osamu Niwa, Hao shen Zhou, Takeo Yamada, Itaru Honma

    Analytical Chemistry   74 ( 20 )   5257 - 5262   2002.10

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    We achieved separate detection of the components of 10 ppm of a benzene, toluene, and o-xylene mixture gas by using mesoporous silica powder incorporated in our microfluidic device. The device consists of concentration and detection cells formed of 3 cm × 1 cm Pyrex plates. We first introduced the mixture gas into the concentration cell where it was adsorbed on an adsorbent in a channel formed in the cell. We then raised the temperature using a thin-film heater and introduced the desorbed gas into the detection cell. Here, we measured the changes in the absorption spectra of the mixture gas in the detection cell. We found that the mixture ratio of the compounds in the desorbed gas varies with time because the thermal desorption property of each compound is different from that of the adsorbent. We analyzed the thermal desorption mechanism by comparing two types of silica adsorbents with different pore structures. We found that an adsorbent that has pores with a periodic and uniform nanosized column shape provides better component separation. We concluded that the uniform pore structure might cause the adsorbate molecules to exhibit a homogeneous adsorption state thus revealing the desorption properties of the gas more clearly.

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  • Application of a cubic-like mesoporous silica film to a surface photovoltage gas sensing system Reviewed

    T. Yamada, H. S. Zhou, H. Uchida, M. Tomita, Y. Ueno, I. Honma, K. Asai, T. Katsube

    Microporous and Mesoporous Materials   54 ( 3 )   269 - 276   2002.7

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    A self-ordered cubic-like mesoporous silica film has been successfully fabricated in a metal-insulator-semiconductor (=Au/SiO2 (cubic-like meso)/Si3N4/SiO2/Si) device based on the surface photovoltage (SPV) system and applied to an NO gas sensor. The self-ordered cubic-like mesoporous silica film is synthesized by using as a template in spin coating a nonionic poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO100-PPO65-PEO100) type triblock copolymer surfactant. The sensing characteristics of the self-ordered cubic-like mesoporous SPV system have been investigated by repeated exposure to 100 ppm NO gas and standard air, as well as observation of the alternating (photo) current, which resulted from the physical adsorption and chemical interactions between detected NO gas and the self-ordered cubic-like mesoporous film. In sensing NO gas, this cubic-like mesoporous SPV system exhibits a response nearly five times larger than that of a simple SPV sensor without mesoporous silica film. Even at room temperature, this mesoporous SPV system exhibits a recoverable response. These results can be explained by the characteristics of the cubic-like mesoporous silica film including large surface area and a bi-continuous mesopore structure. This kind of mesoporous film has a great potential for application to highly sensitive and responsive gas sensors. © 2002 Elsevier Science Inc. All rights reserved.

    DOI: 10.1016/S1387-1811(02)00387-6

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  • Surface photovoltage NO gas sensor with properties dependent on the structure of the self-ordered mesoporous silicate film Reviewed

    T. Yamada, H. S. Zhou, H. Uchida, M. Tomita, Y. Ueno, T. Ichino, I. Honma, K. Asai, T. Katsube

    Advanced Materials   14 ( 11 )   812 - 815   2002.6

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    Self-ordered hexagonal and cubic structured mesoporous silicate film combined SPV type gas sensors (SPV-hex and SPV-cub) were successfully fabricated. These sensors have a sensitivity for NO gas and exhibit different sensing performance depending on the accessibility of the mesostructure to the gas.

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  • An application possibility of self-ordered mesoporous silicate for surface photo voltage (SPV) type NO gas sensor (II): Self-ordered mesoporous silicate incorporated SPV device and its sensing property dependence on mesostructure

    Takeo Yamada, Hao Shen Zhou, Hidekazu Uchida, Masato Tomita, Yuko Ueno, Keisuke Asai, Itaru Honma, Teruaki Katsube

    IEICE Transactions on Electronics   E85-C ( 6 )   1304 - 1310   2002.6

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    Self-ordered mesoporous silicate films from organic-inorganic compound materials are successfully fabricated into the surface photo voltage (SPV) type gas sensor device as a gas adsorption insulator layer. These kinds of gas sensors device exhibit NO gas sensing property dependent on their mesoporous film structure. We are succeeded in indication about a possibility of mesoporous silicate film for the SPV type gas sensor application.

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  • An application possibility of self-ordered mesoporous silicate for surface photo voltage type NO gas sensor (I): The characterization of nonionic triblock copolymer templated self-ordered mesoporous silicates and preparation their film for device application

    Takeo Yamada, Hao Shen Zhou, Hidekazu Uchida, Masato Tomita, Yuko Ueno, Keisuke Asai, Itaru Honma, Teruaki Katsube

    IEICE Transactions on Electronics   E85-C ( 6 )   1298 - 1303   2002.6

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    The mesoporous materials from the self-assembled organic-inorganic compound materials have great possibilities for a variety of applications. However, to make use of these kinds of materials effectively, they must be controlled. In this paper, were are succeeded in powder state pore size control and in significantly fabrication film state for device application use.

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  • Air-cooled cold trap channel integrated in a microfluidic device for monitoring airborne BTEX with an improved detection limit Reviewed

    Yuko Ueno, Tsutomu Horiuchi, Osamu Niwa

    Analytical Chemistry   74 ( 7 )   1712 - 1717   2002.4

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    We integrated an air-cooled cold trap (CT) channel in a microfluidic device for monitoring airborne benzene, toluene, ethylbenzene, and xylene (BTEX) gases and demonstrated its effect on improving the detection limit of the microfluidic device. The device consists of concentration and detection cells formed of 3 × 1 cm Pyrex plates. We first introduced a sample gas into the concentration cell, and the gas was adsorbed onto an adsorbent in the channel. We then raised the temperature using a thin-film heater and introduced the desorbed gas into the detection cell. To prevent dilution of the gas before detection, we propose an improvement to the concentration cell structure that involves the integration of the CT channel. We examined the CT effect by comparing three types of concentration cell with different channel structures. We found that we could detect a gas concentration about 2 orders of magnitude lower than in our previous work by optimizing the channel structure and integrating a CT channel. As an example of BTEX detection, we obtained a 0.05 ppm detection limit for toluene gas with a sampling time of 30 min.

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  • Study of reactor-NO2-gas diffusion in a porous glass chip by near-infrared Raman spectroscopy Reviewed

    Y Ueno, K Ajito, YY Maruo

    PHYSICAL CHEMISTRY CHEMICAL PHYSICS   4 ( 11 )   2341 - 2345   2002

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    We have used near-infrared (NIR) Raman spectroscopy to study a coloration reaction that occurs in nano-sized pores in a porous glass chip. This coloration reaction is a modified Saltzman reaction that produces an azo dye by selective reaction with nitrogen dioxide gas (NO2). Neither the details of the reaction mechanisms in the nano-sized pores nor the interaction between the products and the pore surface have previously been investigated. We analyzed the mechanism by measuring the Raman intensity of the azo dye produced in the pores. We found that, in the early stages of NO2 exposure, the NO2 gas reacts at the surface of the porous glass chip, while in the later stages more NO2 gas diffuses into deeper areas without reacting with the reagent. We estimated the limit of the NO2 gas diffusion distance to be about 500 m We also analyzed the interaction between the azo dye and the surface of the pores by comparing the Raman spectrum in the porous glass chip with that in a bulk d(4)-methanol solution. The azo dye is mainly adsorbed as a result of hydrogen bonding between the pi-electrons of the phenyl group and the silanol of the glass surface. We also determined that the azo dye has a trans-conformation molecular structure by calculating the total steric energy. The interaction between the azo group and the silanol is weaker in the adsorbed state than in bulk, due to the steric effect of the bulky substituents around the azo group. Our proposed geometry for the azo dye adsorbed on the surface of the pores has a flatter orientation.

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  • Micro-fluidic device to detect airborne VOCs for environmental monitoring Reviewed

    Tsutomu Horiuchi, Yuko Ueno, Osamu Niwa

    NTT R and D   51 ( 5 )   16 - 22   2002

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    We developed a micro-fluidic device to identify and quantify airborne aromatic volatile organic compounds (VOCs: benzene, toluene, and xylenes) in car exhaust fumes. The device consists of concentration- and detection-cells made of glass plates. The concentration-cell is composed of an adsorbent to concentrate VOC gases and a thin-film platinum heater to desorb the concentrated gas thermally. Absorption spectra of the concentrated gases are measured in the detection-cell which is connected to the concentration-cell. We successfully measured 50 ppb of toluene. This device is expected to be applied in field monitoring because it is easy to maintain and can measure VOCs every hour.

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  • Microfluidic device for airborne BTEX detection

    Ueno, Y, Horiuchi, T, Morimoto, T, Niwa, O

    ANALYTICAL CHEMISTRY   73 ( 19 )   4688 - 4693   2001.10

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  • チャネル型ポリマ導波路の可視内部反射分光法への応用

    堀内 勉, 森本 孝, 上野 祐子, 丹羽 修, 飛田 達也, 今村 三郎

    電気学会論文誌. A, 基礎・材料・共通部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A, A publication of Fundamentals and Materials Society   121 ( 7 )   654 - 659   2001.7

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  • Soft X-ray emission and absorption spectroscopy of hydrofullerene Reviewed

    Yasuji Muramatsu, Yuko Ueno, Takayoshi Hayashi, Melissa M. Grush, Eric M. Gullikson, Rupert C.C. Perera

    Journal of Electron Spectroscopy and Related Phenomena   107 ( 2 )   177 - 184   2001.5

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    High-resolution soft X-ray emission and absorption spectra in the C K region of hydrofullerene, which probably consists mainly of C60H36, were measured using highly brilliant synchrotron radiation to identify its molecular structure and electronic structure. Comparison with the C2p-DOS spectra, calculated by discrete variational (DV) Xα molecular orbital calculations, of three possible C60H36 isomers, showed that the measured X-ray spectra approximately agreed with the calculated C2p-DOS spectra of the T-symmetry isomer. The X-ray spectral features were explained by the electronic structure hybridized between the sp2 and sp3 carbon atoms of the T-symmetry C60H36. © 2000 Elsevier Science B.V.

    DOI: 10.1016/S0368-2048(00)00101-8

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  • Experimental technique for radiative-process-resolved X-ray absorption spectroscopy at the inner-shell excitation thresholds Reviewed

    Yasuji Muramatsu, Yuko Ueno, Teikichi A. Sasaki, Eric M. Gullikson, Rupert C.C. Perera

    Journal of Synchrotron Radiation   8 ( 2 )   369 - 371   2001.3

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    Partial-fluorescence-yield (PFY) x-ray absorption measurements, using the optimized window widths of position sensitive detectors in wave-length dispersive x-ray spectrometers, have been applied for radiative-process-resolved (RPR) x-ray absorption spectroscopy. We have measured PFY-absorption spectra of graphite and diamond at the C K threshold and of h-BN and c-BN at the B K threshold. Resonant elastic x-ray scattering was observed in graphite and h-BN on their PFY-absorption spectra, and excitonic x-ray scattering was observed in diamond and c-BN. These results show that PFY-absorption measurements for RPR x-ray absorption spectroscopy can provide the information about the electronic structures and the radiative-decay process in inner-shell excitation.

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  • Soft X-ray emission spectra in the O K region of oxygen incorporated in microporous carbon Reviewed

    Yasuji Muramatsu, Masamitsu Watanabe, Yuko Ueno, Shik Shin, Rupert C.C. Perera

    Journal of Electron Spectroscopy and Related Phenomena   114-116   301 - 305   2001.3

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    Soft X-ray emission spectra in the O K region of oxygen incorporated in microporous carbon were measured using synchrotron radiation, in order to observe directly the oxygen on the graphitic surface in micropores and obtain information about its chemical bonding states. The O K X-ray emission spectra of the microporous carbon exhibited a main peak at 526 eV with a low-energy tail, and the reference compounds also exhibited similar spectral features. A spectral feature analysis of the reference compounds using discrete variational Xα molecular orbital calculations showed that the measured 526-eV peaks of the microporous carbon may be due to O2p orbitals and the low-energy tails be to the hybridized O2p/O2s orbitals.

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  • Soft X-ray emission and absorption spectra in the O K region of oxygen incorporated in microporous carbon Reviewed

    Yasuji Muramatsu, Yuko Ueno, Youichi Ishiwata, Ritsuko Eguchi, Masamitsu Watanabe, Shik Shin, Rupert C.C. Perera

    Carbon   39 ( 9 )   1399 - 1402   2001

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    Soft X-ray emission and absorption spectra in the O K region of oxygen incorporated in microporous carbon were measured using synchrotron radiation, in order to directly observe the oxygen and identify its chemical bonding states on the graphitic surface in microporous carbon. The O K X-ray emission spectrum exhibits a peak at 526 eV with a low-energy tail, and the absorption spectrum at the O K threshold exhibits a sharp peak at 531.5 eV and then rises from 535 eV. Spectral feature analysis using DV-Xα molecular orbital calculations show that the measured X-ray spectra are not sufficiently explained by H2O or typical substituents, such as -OH, -CHO, and -COOH, on the graphitic surfaces. © 2001 Elsevier Science Ltd.

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  • Near-Infrared Raman Spectra of Azo Dye Produced by a Nitrogen-Dioxide-Gas-Selective Coloration Reaction in a Porous Glass Chip Reviewed

    Ueno Yuko, Ajito Katsuhiro, Maruo Yasuko Yamada, Niwa Osamu, Torimitsu Keiichi, Ichino Toshihiro

    Applied Spectroscopy   55 ( 9 )   1151 - 1154   2001

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    We directly observed azo dye in a porous glass chip by near-infrared (NIR) Raman spectroscopy. We produced the dye by a modified Saltzman reaction by using sulfanilamide (SFA) and N, N-dimethyl-1-naphthylamine (DMNA) as reagents and used it for the selective sensing of atmospheric nitrogen dioxide gas (NO2). The use of NIR laser excitation is particularly advantageous for the direct measurement of azo dye because it avoids the problem of interference from fluorescence. We obtained the 1597 cm-1 band assigned to the phenyl group stretching mode and the 1415 cm-1 band assigned to the azo group stretching mode. The Raman intensity and visible absorption intensity of the peaks of the azo dye in a porous glass chip increased as we increased the exposure time to NO2. This allowed us to monitor the NO2-sensing reaction in a porous glass chip using NIR Raman spectroscopy. Furthermore, we determined the depth profiles of the azo dye concentration in the porous glass chip by confocal NIR Raman spectroscopy and found that they were different in the early and later NO2-exposure stages. This result indicates that the consumption of the NO2-sensing reagents that accompany azo dye production occurs preferentially at the surface to the deeper regions of the porous glass chip.

    DOI: 10.1366/0003702011953397

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  • Soft X-ray emission and absorption spectra in the C K region of sputtered amorphous carbon films Reviewed

    Yasuji Muramatsu, Sigeru Hirono, Sigeru Umemura, Yuko Ueno, Takayoshi Hayashi, Melissa M. Grush, Eric M. Gullikson, Rupert C.C. Perera

    Carbon   39 ( 9 )   1403 - 1407   2001

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    Soft X-ray emission and absorption spectra in the C K region of amorphous carbon films systematically deposited by RF, ion-beam, and ECR sputtering under various deposition conditions were measured using highly brilliant synchrotron radiation. A broad main peak and a high-energy shoulder were observed in the emission spectra, and a fine structure consisting of at least five peaks was observed in the absorption spectra. By analogy to the occupied/unoccupied C2p-DOS obtained by DV-Xα molecular orbital calculations of simple cluster models composed of sp2 and sp3 carbon atoms, we approximately explained the spectral features in the measured X-ray emission spectra by σ and π bonds and estimated the fine structures in the absorption spectra by the hybridized unoccupied molecular orbitals formed by the local-structures composed of sp2 and sp3 carbon atoms. © 2001 Elsevier Science Ltd.

    DOI: 10.1016/S0008-6223(00)00260-8

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  • Chemical bonding state analysis of silicon carbide layers in Mo/SiC/Si multilayer mirrors by soft x-ray emission and absorption spectroscopy Reviewed

    Yasuji Muramatsu, Hisataka Takenaka, Yuko Ueno, Eric M. Gullikson, Rupert C.C. Perera

    Applied Physics Letters   77 ( 17 )   2653 - 2655   2000.10

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    Soft x-ray emission and absorption spectra in the C K region of Mo/SiC/Si multilayer mirrors were measured using highly brilliant synchrotron radiation to identify the chemical bonding states of the buried silicon carbide layers. Comparison with the C 2p density of state (DOS) spectra, calculated by discrete variational-Xα molecular orbital calculations, of several SiC-based cluster models showed that the measured x-ray spectra approximately agreed with the calculated C 2p-DOS spectra of the c- and h-SiC-based SiCx models in which some silicon atoms were replaced by carbon atoms. The chemical bonding states of the silicon carbide layers in the Mo/SiC/Si multilayer mirrors were therefore estimated to be carbon-excessive silicon carbide. © 2000 American Institute of Physics.

    DOI: 10.1063/1.1318231

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  • Configurations of benzene and pyridine molecules adsorbed on graphitic surface of microporous carbon Reviewed

    Yuko Ueno, Yasuji Muramatsu, Melissa M. Grush, Rupert C.C. Perera

    Journal of Physical Chemistry B   104 ( 30 )   7154 - 7162   2000.8

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    The possible configurations of benzene and pyridine molecules adsorbed in microporous carbon were analyzed by synchrotron-radiation-excited soft X-ray emission spectroscopy and by analyzing its spectral features using DV-Xα molecular orbital calculations. The distances between the adsorbed molecules and the graphitic surface were estimated to be approximately 0.33 nm in both benzene- and pyridine-adsorbed systems. Both molecular orientations were also estimated to be almost parallel to the graphitic surface of microporous carbon. The electronic states of benzene and pyridine molecules adsorbed on the graphitic surface were similar to those of individual nonadsorbed free molecules. Therefore, the adsorption of benzene and pyridine molecules in the microporous carbon can be confirmed to be physisorption, and there is little charge-transfer between the adsorbed molecules and the graphitic surface.

    DOI: 10.1021/jp000669s

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  • Direct observation of benzene and pyridine molecules adsorbed in microporous carbon using synchrotron-radiation-excited soft X-ray emission spectroscopy Reviewed

    Yuko Ueno, Yasuji Muramatsu

    Carbon   38 ( 14 )   1939 - 1942   2000

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    Benzene and pyridine molecules adsorbed in micropores of microporous carbon were directly observed by synchrotron-radiation-excited soft X-ray emission spectroscopy. There were spectral feature differences in C K X-ray emission between the adsorbate benzene and pyridine molecules, while the X-ray spectra agreed closely with their corresponding calculated C2p-DOS spectra. These results show that synchrotron-radiation-excited soft X-ray emission spectroscopy is a powerful tool for in-situ direct observation of molecular adsorbates in bulk microporous materials and for investigating their electronic structures and chemical bonding states in micropores.

    DOI: 10.1016/S0008-6223(00)00031-2

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  • Series : One point advice for searchers(18). Search Strategy for System Limited Clear

    Ueno Yuko

    The Journal of Information Science and Technology Association   45 ( 9 )   466 - 467   1995

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    DOI: 10.18919/jkg.45.9_466

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Books

  • Chemical, Gas, and Biosensors for the Internet of Things and Related Applications

    K. Mitsubayashi, O. Niwa, Y. Ueno( Role: Joint editor)

    Elsevier  2019.6  ( ISBN:9780128154090

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  • Encyclopedia of Spectroscopy and Spectrometry 3rd Edition

    K. Ajito, M. Nakamura, T. Tajima, Y. Ueno( Role: ContributorChapter 18 Terahertz Spectroscopy Methods and Instrumentation)

    Academic Press,Elsevier  2016.10  ( ISBN:9780128032244

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    Total pages:3584   Responsible for pages:432-437   Language:English   Book type:Scholarly book

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  • Handbook of Terahertz Technologies: Devices and Applications

    Y. Ueno, K. Ajito( Role: ContributorChapter 15 THz chemical spectroscopy)

    Jenny Stanford Publishing  2015.3  ( ISBN:9814613088

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MISC

  • Self-folding graphene-based electrode array for electrophysiology of three-dimensional cell culture

    20 ( 1 )   15 - 18   2021.3

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  • グラフェン表面へのバイオインターフェース構築と発光型バイオセンサへの応用 (特集 メタマテリアル) Reviewed

    古川 一暁, 上野 祐子

    光技術コンタクト = Optical and electro-optical engineering contact   54 ( 11 )   17 - 26   2016.11

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  • オンチップ型グラフェンアプタセンサ (特集 バイオ・ソフトマテリアル研究の最前線)

    上野 祐子

    NTT技術ジャーナル   28 ( 6 )   31 - 35   2016.6

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  • グラフェンを用いた発光型バイオセンサ

    古川 一暁, 上野 祐子

    応用物理   85 ( 6 )   496 - 500   2016

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  • グラフェンを生体分子インターフェースに用いたオンチップ型FRETバイオセンサ Reviewed

    上野 祐子, 古川 一暁

    炭素   2016 ( 275 )   199 - 207   2016

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  • 酸化グラフェンのバイオセンシング応用とオンチップデバイス化 (特集 酸化グラフェンの産業応用)

    古川 一暁, 上野 祐子

    ファインケミカル : 調査・資料・報道・抄録   44 ( 2 )   46 - 53   2015.2

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  • 多孔質材料中に生成されたコクリスタルの低波数ラマン分光測定

    太田竜一, 太田竜一, 上野祐子, 味戸克裕

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)   76th   2015

  • Graphene oxide-based FRET aptasensor on solid support

    Kazuaki Furukawa, Yuko Ueno

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   248   2014.8

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  • On-chip FRET aptasensor built on the surface of graphene derivative

    UENO Yuko, FURUKAWA Kazuaki

    Technical report of IEICE. SDM   113 ( 351 )   73 - 78   2013.12

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    We have designed a label-free protein detection system on an aptamer modified graphene oxide (GO) surface fixed on a solid support. The aptasensor we studied uses fluorescence resonance energy transfer (FRET) between the dye at the terminus and the GO surface. Our system can be installed in a microfluidicdevice, that enables us accurate quantitative evaluation of the fluorescence intensity. We successfully demonstrated an enhancement in the sensitivity of an on-chip GO aptasensor by using an originally designed biomolecular probe for highly sensitive protein detection. The performance of the designed probes was examined quantitatively by using a multichannel linear-array GO aptasensor.

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  • 酸化グラフェン表面を用いたバイオセンシング (特集 グラフェン研究最前線)

    古川 一暁, 上野 祐子

    NTT技術ジャーナル   25 ( 6 )   27 - 30   2013.6

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  • グラフェン表面に構築する生体分子インターフェース : 酸化グラフェンアプタセンサの固体表面への構築とオンチップ化

    古川 一暁, 上野 祐子

    Molecular electronics and bioelectronics   24 ( 2 )   101(39) - 106(44)   2013.5

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  • ナプロキセンNaの擬似結晶多形の固体NMRとテラヘルツ分光による同定

    植田圭祐, 東顕二郎, 上野祐子, キム ジェヨン, 味戸克裕, 山本恵司, 森部久仁一

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2013   2013

  • テラヘルツ化学イメージング法を用いた医薬品共結晶の分析

    上野祐子, 味戸克裕, 久々津直哉, 為近恵美

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2012   2012

  • グラフェン修飾くし形電極を用いた生体関連物質の高感度検出

    上野祐子, 古川一暁, 日比野浩樹, 為近恵美

    日本化学会講演予稿集   92nd ( 3 )   2012

  • アプタマ修飾した酸化グラフェンを用いた新規タンパク質検出法の提案と実証

    古川一暁, 上野祐子, 為近恵美, 日比野浩樹

    応用物理学会学術講演会講演予稿集(CD-ROM)   73rd   2012

  • テラヘルツ化学イメージングによる医薬分子の可視化 (特集 安心・安全のためのイメージング・センシング技術)

    味戸 克裕, 上野 祐子, ソン ホ ジン

    NTT技術ジャーナル   23 ( 12 )   34 - 38   2011.12

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  • キラル光学活性有機分子のテラヘルツ吸収分光

    高橋淳一, 上野祐子, 味戸克裕

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2011   2011

  • H2ブロッカーの薬効成分の結晶多形のテラヘルツ分光スペクトルおよび振動解析

    上野祐子, 味戸克裕, 久々津直哉, 為近恵美

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2011   2011

  • グラフェン修飾金くし形電極チップの作製法および電極特性

    上野祐子, 古川一暁, 日比野浩樹, 為近恵美

    日本分析化学会年会講演要旨集   60th   2011

  • グラフェン修飾金電極を用いた酵素反応検出

    上野祐子, 古川一暁, 日比野浩樹, 為近恵美

    日本化学会講演予稿集   91st ( 3 )   2011

  • テラヘルツ分光によるケーブル外被の劣化評価

    高橋和枝, 味戸克裕, 上野祐子, 小川重男

    日本化学会講演予稿集   91st ( 3 )   2011

  • テラヘルツ時間領域分光法を用いたサプリメント錠剤中のアミノ酸の定量分析

    上野祐子, 味戸克裕, 久々津直哉, 為近恵美

    東京コンファレンス講演要旨集   2010   2010

  • テラヘルツ分光のバイオ・メディカル応用

    味戸克裕, 上野祐子, 芳賀恒之, 久々津直哉

    電子情報通信学会大会講演論文集   2009   2009

  • テラヘルツ分光分析のスペクトル解析技術~定性から定量へ~

    上野祐子, 味戸克裕, 久々津直哉, 芳賀恒之

    東京コンファレンス講演要旨集   2009   2009

  • テラヘルツ分光技術 (特集 ミリ波・テラヘルツ波応用技術)

    味戸 克裕, 上野 祐子, 芳賀 恒之

    NTT技術ジャ-ナル   20 ( 12 )   33 - 36   2008.12

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  • メソポーラスシリカの分子認識機能とマイクロ分析デバイスへの応用 Invited Reviewed

    上野 祐子

    分析化学 = Japan analyst   57 ( 11 )   871 - 881   2008.11

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  • テラヘルツ時間領域分光法による生体関連分子の化学分析

    味戸克裕, 上野祐子

    分析化学討論会講演要旨集   68th   2007

  • メソポーラスシリカのナノ細孔に吸着した芳香族カルボン酸のテラヘルツ時間領域分光スペクトル

    上野祐子, 味戸克裕

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2007   2007

  • テラヘルツ時間領域分光法を用いた無機塩類イオン対の検出

    味戸克裕, 上野祐子, ルンサワーン ラクチャノック, 永妻忠夫, 芳賀恒之, 久々津直哉

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2007   2007

  • テラヘルツ分光スペクトルデータベースを用いたアミノ酸の定量定性分析

    上野祐子, LV Luodong, ZHANG Zhaohui, YIN Yixin, 味戸克裕

    分析化学討論会講演要旨集   68th   2007

  • テラヘルツ時間領域分光法による生体関連分子の化学分析

    味戸克裕, 上野祐子

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2007   2007

  • テラヘルツ分光法を用いた化学分析の進展~生体関連分子の水素結合ネットワークの解析に向けて~

    味戸克裕, 上野祐子

    日本分光学会赤外ラマン分光部会シンポジウム   2nd   2007

  • テラヘルツ時間領域分光によるナノ細孔に吸着した有機酸分子の分子内・分子間相互作用の研究

    上野祐子, 富田勲, 味戸克裕

    日本化学会講演予稿集   87th ( 1 )   2007

  • オンサイト連続モニタリング用可搬型芳香族系VOCセンサ (特集 ユビキタスセンサ)

    堀内 勉, 上野 祐子, Camou Serge

    NTT技術ジャ-ナル   18 ( 6 )   13 - 16   2006.6

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  • ナノ構造材料を用いたテラヘルツ時間分解分光法

    上野祐子, 上野祐子, RUNGSAWANG Rakchanok, 富田勲, 富田勲, 味戸克裕

    分析化学討論会講演要旨集   67th   2006

  • アミノ酸およびタンパク質のTHz分光

    味戸克裕, RUNGSAWANG Rakchanok, 上野祐子, 富田勲

    応用物理学関係連合講演会講演予稿集   53rd ( 0 )   2006

  • テラヘルツ時間領域分光法によるアミノ酸結晶の定量分析と角度依存解析

    味戸克裕, RUNGSAWANG R., 富田勲, 上野祐子

    日本分光学会テラヘルツ分光部会シンポジウム講演要旨集   2006   2006

  • 擬似位相整合GaPを用いた1.55μm帯レーザ励起によるテラヘルツ差周波発生

    富田勲, 竹ノ内弘和, 鈴木博之, 味戸克裕, RUNGSAWANG R., 上野祐子

    応用物理学関係連合講演会講演予稿集   53rd ( 3 )   2006

  • ユビキタス化学センサー

    岩崎 弦, 丸尾 容子, 上野 祐子

    化学と工業 = Chemistry and chemical industry   57 ( 10 )   1043 - 1046   2004.10

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  • ナノ多孔質材料によるガス濃縮と分光検出法を用いたマイクロBTXガスセンサ

    上野 祐子

    分光研究 = Journal of the spectroscopical research of Japan   52 ( 4 )   225 - 229   2003.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:社団法人 日本分光学会  

    DOI: 10.5111/bunkou.52.225

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  • ナノ多孔質材料を用いたマイクロセンサ

    上野 祐子

    表面技術 = The Journal of the Surface Finishing Society of Japan   53 ( 12 )   902 - 905   2002.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:一般社団法人 表面技術協会  

    DOI: 10.4139/sfj.53.902

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  • 大気環境モニタリング用VOC検出マイクロフローデバイス (特集論文 高感度センシング技術)

    堀内 勉, 上野 祐子, 丹羽 修

    NTT R & D   51 ( 5 )   372 - 378   2002.5

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  • 近赤外顕微ラマン分光法による多孔質ガラスチップ中の色素評価

    上野祐子, 味戸克裕, 丸尾容子

    応用物理学会学術講演会講演予稿集   62nd ( 3 )   2001

  • 近赤外ラマン分光法による多孔質ガラス中のNO2選択反応の観測

    上野祐子, 味戸克裕, 丸尾容子, 丹羽修, 鳥光慶一, 市野敏弘

    日本化学会講演予稿集   79th ( 1 )   2001

  • Interaction between Surface of Nano-Sized Pores of a Porous Glass Chip and Azo Dye Produced by a NO2-Selective Reaction in the Pores.

    上野祐子, 味戸克裕, 丸尾容子

    分子構造総合討論会講演要旨集   2001   2001

  • Analysis of a NO2-Selective Coloration Reaction in Nano-Sized Pores by Near-Infrared Raman Spectroscopy.

    上野祐子, 味戸克裕, 丸尾容子

    日本化学会講演予稿集   80th   2001

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Presentations

  • 単層グラフェンを用いた化学・バイオセンサ

    上野祐子

    2023 年 電子情報通信学会総合大会  2023.3 

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  • 単層グラフェンを用いた化学・バイオセンサ

    上野祐子

    有機エレクトロニクス研究会  2023.2 

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  • Biosensing Interface using Aptamer-modified Graphene Invited

    Yuko Ueno

    The Fifth International Workshop on Symbiosis of Biology and Nanodevices (IWSBN5)  2022.12 

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  • Chemical and Biosensors Using Monolayer Graphene Invited

    Yuko Ueno

    15th International Symposium on Nanomedicine  2022.12 

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  • 機能分子修飾単層グラフェン電極による水溶性および脂溶性ビタミンの電気化学検出特性

    李明澤, 小貫聖美, 上野祐子

    令和4年度 日本分析化学会関東支部若手交流会  2022.11 

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  • 酸化グラフェンのレイヤー数によるバイオセンサの高感度化

    木島里緒, 的野拓也, 上野祐子

    第12回 CSJ化学フェスタ2022  2022.10 

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  • 単層グラフェン電極とグラファイトベーサル面を用いた尿酸の電気化学反応におけるカリウムイオンの影響の比較

    鈴木涼平, 児島彩笑, 家田知里, 丹羽修, 上野祐子

    第12回 CSJ化学フェスタ2022  2022.10 

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  • 単層グラフェン電極とグラファイトベーサル面電極を用いた電気化学反応におけるカリウムイオンの影響

    児島彩笑, 鈴木涼平, 家田知里, 丹羽修, 上野祐子

    第12回 CSJ化学フェスタ2022  2022.10 

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  • ピレン骨格を結合した脂質分子を含む巨大ベシクルとグラフェン基板との相互作用

    兼子綺人, 的野拓也, 上野祐子

    第12回 CSJ化学フェスタ2022  2022.10 

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  • 単層グラフェン表面を用いた化学・バイオセンサ Invited

    上野祐子

    第83回応用物理学会秋季講演会  2022.9 

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  • くし形電極を用いた両連続相マイクロエマルション中のレドックス化学種の拡散挙動

    鈴木麟太朗, 楢府祥, 丹羽修, 上野祐子

    日本分析化学会第71年会  2022.9 

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  • 単層グラフェン電極表面でのドーパミン酸化体の還元反応におけるカリウムイオンのインヒビター効果

    家田知里, 児島彩笑, 鈴木涼平, 丹羽修, 上野祐子

    日本分析化学会第71年会  2022.9 

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  • β-CD修飾単層グラフェン電極を用いた両連続相中でのシアニジンの電気化学測定

    楢府祥, 高島義徳, 丹羽修, 矢嶋龍彦, 上野祐子

    日本分析化学会第71年会  2022.9 

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  • 単層グラフェン電極を用いた電気化学活性な生体分子検出におけるカリウムイオンの影響

    鈴木涼平, 児島彩笑, 家田知里, 丹羽修, 上野祐子

    日本分析化学会第71年会  2022.9 

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  • アプタマ修飾単層酸化グラフェンを内包したジャイアントベシクルの作製法

    的野拓也, 野出航平, 兼子綺人, 上野祐子

    日本分析化学会第71年会  2022.9 

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  • 単層グラフェン表面でのアニオン種の酸化還元反応におけるカリウムイオンのプロモーター効果

    児島彩笑, 鈴木涼平, 家田知里, 丹羽修, 上野祐子

    日本分析化学会第71年会  2022.9 

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  • 分子認識機能材料の創生とマイクロ空間における化学・バイオセンシング応用 Invited

    上野祐子

    2022年電気化学秋季大会・第71回化学センサ研究発表会  2022.9 

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  • 単層グラフェン電極に吸着したカリウムイオンが生体分子検出に与える影響

    児島彩笑, 鈴木涼平, 家田知里, 丹羽修, 上野祐子

    2022年電気化学秋季大会  2022.9 

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  • β-シクロデキストリン修飾単層グラフェン電極を用いた両連続相中のフェロセンの電気化学的分析

    楢府祥, 大崎基史, 高島義徳, 丹羽修, 矢嶋龍彦, 上野祐子

    第82回分析化学討論会  2022.5 

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  • 単層グラフェン電極を用いた Ir 錯体検出における カリウムイオンのプロモーター効果

    児島彩笑, 丹羽修, 上野祐子

    第70回化学センサ研究会・電気化学会第89回大会  ( オンライン )   2022.3  化学センサ研究会・電気化学会

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  • 単層グラフェンを用いたセンシングデバイスの作製と応用

    上野 祐子

    有機エレクトロニクス研究会  ( J:COMホルトホール大分・オンライン )   2022.2  電子情報通信学会有機エレクトロニクス研究会

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  • Biosensing Interface using Surface-modified Graphene Invited International conference

    Yuko Ueno

    The Material Research Meeting 2021  ( Yokohama, Japan/Digital )   2021.12  The Material Research Meeting

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  • Graphene-based FRET Micro Biosensors Invited International conference

    Yuko Ueno

    Pacifichem 2021  ( Digital )   2021.12  Pacifichem

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  • Graphene-based Bio/Chemical Sensors Invited International conference

    Yuko Ueno

    14th International Symposium on Nanomedicine  ( Digital meeting )   2021.11  International Symposium on Nanomedicine

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  • 水和法により作製したベシクル膜への水溶性色素の取り込み

    野出航平, 上野祐子

    東日本分析化学若手交流会  ( オンライン )   2021.11  分析化学会関東支部・東北支部

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  • ピレン修飾巨大リポソームの作製と酸化グラフェンとの相互作用解析

    佐藤雅記, 渡邉貴嘉, 的野拓也, 野出航平, 上野祐子, 松浦友亮, 芳坂貴弘, 鈴木宏明

    化学とマイクロ・ナノシステム学会 第44 回研究会  ( オンライン )   2021.11  化学とマイクロ・ナノシステム学会

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  • シクロデキストリン修飾グラフェン電極の両連続相における電気化学特性

    楢府祥, 上野祐子, 大崎基史, 高島義徳

    第11回CSJ化学フェスタ2021  ( オンライン )   2021.10  日本化学会関東支部

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  • アプタマー修飾グラフェンのバイオセンサ応用 Invited

    上野 祐子

    第70回高分子討論会  ( オンライン )   2021.9 

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  • グラフェンを利用したマイクロバイオセンサ Invited

    上野 祐子

    電子情報通信学会ソサイエティ大会  ( オンライン )   2021.9  電子情報通信学会

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  • アプタマー修飾単層マイクロ酸化グラフェンの作製法とバイオセンサ応用

    的野拓也, 上野祐子

    日本分析化学会第70年会  ( オンライン )   2021.9  日本分析化学会

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  • 単層グラフェン電極を用いたカリウムイオン検出

    児島彩笑, 上野祐子

    第69回化学センサ研究会・2021年電気化学秋季大会  2021.9  化学センサ研究会・電気化学会

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  • Graphene-based Bio/Chemical Sensors Invited International conference

    Yuko Ueno

    The Eighteenth International Symposium on Electroanalytical Chemistry  ( Digital meeting )   2021.8  International Symposium on Electroanalytical Chemistry

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  • Graphene-Based Microsensors Invited International conference

    Yuko Ueno

    The 239th ECS Meeting with the 18th International Meeting on Chemical Sensors  ( Digital )   2021.6  ECS

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  • ハイドロゲル表面シワ構造をガイドにした細胞配列制御

    田中あや, 高橋陸, 宮廻裕樹, 上野祐子, 山口真澄

    2021年第68回応用物理学会春季学術講演会  2021.3  応用物理学会

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  • Diffusive Fluidic Devices Based on Buckle-Delaminated Hydrogel Architectures

    R. Takahashi, H. Miyazako, A. Tanaka, Y. Ueno

    the 30th Annual Meeting of MRS-J  ( Online )   2020.12  MRS Japan

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  • 自己組立てグラフェン電極による三次元培養組織の活動計測

    酒井洸児, 手島哲彦, 上野祐子, 中島寛, 山口真澄

    化学とマイクロ・ナノシステム学会 第42回研究会(Cheminas42)  ( オンライン開催 )   2020.10  化学とマイクロ・ナノシステム学会

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  • 水圏環境下でイオン・分子認識機能を発現するグラフェン機能材料の開拓 Invited

    上野 祐子

    日本化学会化学フェスタ  ( オンライン開催 )   2020.10  日本化学会関東支部

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  • 多層グラフェンの自己組立て

    後藤東一郎, 手島哲彦, 上野祐子, 山口真澄

    2020年第81回応用物理学会秋季学術講演会  ( オンライン開催 )   2020.9  応用物理学会

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  • Graphene-based micro biosensors Invited International conference

    Yuko Ueno

    11th International Symposium on Organic Molecular Electronics (ISOME2020)  ( Online )   2020.8  Organic Molecular Electronics (OME), Society of the Institute of Electronics, Information and Communications Engineers (IEICE)

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  • グラフェンFRETバイオセンサにおけるグラフェン層数による蛍光強度変化 (界面,バイオテクノロジー)

    上野 祐子, 宮廻 裕樹, 古川 一暁

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報  2020.2  電子情報通信学会

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  • グラフェンFRETアプタセンサにおける蛍光強度の層数依存性

    上野 祐子, 宮廻 裕樹, 古川 一暁

    Proceedings of the Chemical Sensor Symposium  2019.9  電気化学会化学センサ研究会

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  • 耐久性の高いグラフェン微小電極の製造を可能にする表面処理方法 (有機エレクトロニクス)

    上野 祐子, 傳刀 賢二, 本間 幸英, 古川 一暁

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報  2019.2  電子情報通信学会

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  • Graphene FRET aptasensor built on a solid support International conference

    Ueno, Yuko, Teshima, Tetsuhiko, Henderson, Calum, Nakashima, Hiroshi

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  2017.4 

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  • Self-propelled ionic gel at air-water interface International conference

    Furukawa, Kazuaki, Teshima, Tetsuhiko, Ueno, Yuko

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  2017.4 

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  • グラフェンを利用したオンチップ型FRETアプタセンサによるタンパク質の検出 (有機エレクトロニクス)

    上野 祐子, 古川 一暁

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報  2015.11  電子情報通信学会

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  • Graphene oxide-based FRET aptasensor on solid support International conference

    Furukawa, Kazuaki, Ueno, Yuko

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  2014.8 

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  • グラフェン誘導体表面に構築したオンチップ型FRETアプタセンサ

    上野 祐子, 古川 一暁

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報  2013.12  一般社団法人電子情報通信学会

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  • 酸化グラフェンを用いたタンパク質検出機構の局所観察とマイクロパターニング

    古川 一暁, 上野 祐子

    表面科学学術講演会要旨集  2013  公益社団法人 日本表面科学会

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  • CS-7-4 テラヘルツ分光のバイオ・メディカル応用(CS-7.バイオメディカル分野を支える最新の光・マイクロ波技術,シンポジウムセッション)

    味戸 克裕, 上野 祐子, 芳賀 恒之, 久々津 直哉

    電子情報通信学会ソサイエティ大会講演論文集  2009.9  一般社団法人電子情報通信学会

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  • 30 円偏光照射によるα-メチルアミノ酸薄膜への不斉導入

    高橋 淳一, 上野 祐子, 小川 智也, 島 壮一郎, 金子 竹男, 小林 憲正, 三田 肇, 阿達 正浩, 加藤 政博, 保坂 将人

    Viva origino  2009  文部省科学研究費総合研究(B)「原始地球上における生命の起源に関する研究」班

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  • イソバリン固相薄膜への円偏光照射によるキラリティ発現

    高橋 淳一, 加藤 政博, 上野 祐子, 小川 智也, 島 壮一郎, 金子 竹男, 小林 憲正, 三田 肇, 阿達 正浩, 保坂 将人

    日本地球化学会年会要旨集  2008  一般社団法人日本地球化学会

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    ラセミックな DL-イソバリン固相薄膜に,自由電子レーザーからの純粋円偏光を照射したところ、照射前には観測されなかった円二色性が観測された。Cotton 極大の符号は照射円偏光のヘリシティ符号(左 or 右まわり)により完全に逆転し,対称的な二色性スペクトルが得られた。照射後の吸収スペクトルはわずかに低エネルギー側にシフトするものの極大形状は照射前とほぼ変化がなかったことから,分子の単純な不斉分解ではなく,分子配座変化を伴う構造変化によるキラル発現であると推測される。この結果は,無生物的に生成されたラセミックな有機物が,低温の星間物質表面に吸着した状態であっても,宇宙空間に存在する円偏光への曝露により,そのヘリシティに対応した対称性方向のキラリティを発現しうることを示す。

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  • ANYL 107-Study of intra- and intermolecular hydrogen bond systems by terahertz time-domain spectroscopy International conference

    Ueno, Yuko, Rungsawang, Rachanok, Tomita, Isao, Ajito, Katsuhiro

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  2006.9 

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  • ナノ多孔質材料を用いたマイクロBTXセンサ

    上野 祐子, 堀内 勉, 丹羽 修

    Proceedings of the Chemical Sensor Symposium  2003.4  電気化学会化学センサ研究会

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  • Separation and optical detection of btx-mixture gases using a microfluidic device. International conference

    Ueno, Y

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  2002.4 

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  • 芳香族系VOC検出用微小分光フローセルの作製とその特性

    堀内 勉, 森本 孝, 上野 祐子

    Proceedings of the Chemical Sensor Symposium  2001.4  電気化学会化学センサ研究会

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Awards

  • Seiyama Award

    2022   Japan Association of Chemical Sensors  

    上野 祐子

  • 日本分析化学会女性Analyst賞

    2019   JSAC  

    上野 祐子

  • Bio4Apps Best Presentation Award

    2017   Bio4Apps  

  • 分光イノベーション賞

    2014   分光学イノベーション研究会  

  • 東京コンファレンス優秀ポスター賞

    2009   日本分析化学会,JAIMA  

  • 日本分析化学会奨励賞

    2008   JSAC  

  • 日本化学会春季年会ポスター賞

    2001   日本化学会  

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Research Projects

  • グラフェン表面修飾を利用した多種プローブ搭載マイクロ粒子による物質分離機能

    Grant number:22K04899  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)  中央大学

    上野 祐子

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    Grant amount: \4160000 ( Direct Cost: \3200000 、 Indirect Cost: \960000 )

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  • 水圏環境下でイオン・分子認識機能を発現するグラフェン機能材料の開拓

    Grant number:20H05238  2020.4 - 2022.3

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)  中央大学

    上野 祐子

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    Grant amount: \4550000 ( Direct Cost: \3500000 、 Indirect Cost: \1050000 )

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  • 筒状マイクロエンベロープ内壁に構築するグラフェンバイオインターフェース

    Grant number:17H02759  2017.4 - 2020.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)  日本電信電話株式会社NTT物性科学基礎研究所

    上野 祐子, 手島 哲彦

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    Grant amount: \17680000 ( Direct Cost: \13600000 、 Indirect Cost: \4080000 )

    本研究の目的は,分子や細胞を内包可能な筒状マイクロエンベロープを作製し,エンベロープの内壁に,分子認識場として動作する生体分子インターフェースを構築することにより,内部の中空空間に閉じ込められた生体分子を高感度にかつ選択的に検出する,新規プラットフォームを確立することである.これにより,従来は物質の拡散により単利同定が困難であった,生きた細胞から放出される分泌物などの検出が可能となる.
    本年度は,グラフェン/ポリパラキシレン/シルクフィブロインゲル/アルギン酸ゲルという生体適合性の高い高分子層で構成された積層膜を用いて,最上層のグラフェン表面にアプタマを修飾する方法および,グラフェンを最内層とする筒状マイクロエンベロープを安定に構築する条件を確立した.シルクフィブロインゲルは,合成条件や個体差による硬さや厚さのばらつきが比較的大きく,精密制御の際に課題となることが分かったため,この層を,生体適合性を有するより安定で制御しやすい材料に置換する検討を行った.このようにして作製した,グラフェンを最内層とする筒状マイクロエンベロープの内部に,複数種類の細胞を内包し,数日程度の培養に成功した.さらに,細胞外分泌物の検出を想定した培養環境下において,センシングのバックグラウンドを上昇させる妨害成分およびその影響の大きさを定量的に確認した.
    これらの成果について,招待講演を含む国内外の学会および論文発表を行った.

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  • Quantitative evaluation of energy transfer efficiency to graphene and its derivatives

    Grant number:26286018  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B) 

    Furukawa Kazuaki

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    Grant amount: \16250000 ( Direct Cost: \12500000 、 Indirect Cost: \3750000 )

    Graphene is an excellent acceptor in fluorescence resonance energy transfer (FRET) process in visible light region. Using this characteristics, we developed a biosensor (graphene FRET aptasensor) that emit fluorescence when the target protein exists in a sample. We showed that the graphene FRET aptasensor yields more than 3 times greater fluorescence than GO sensor. We designed the sensor array with internal reference for quantitative detections by combining microfluidics technology to the graphene FRET aptasensor. We showed the limit of detection of the graphene FRET aptasensor is several hundred ng/mL. For the electron transfer reaction of graphene, we built a new surface modification for a substrate to strengthen adhesion between graphene and substrate though the electrochemical properties of graphene is remained.

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